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RAD1 and CSNK2A2
Data Source:
BioGRID
(affinity chromatography technology, enzymatic study)
RAD1
CSNK2A2
Description
RAD1 checkpoint DNA exonuclease
casein kinase 2 alpha 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Chromosome
Checkpoint Clamp Complex
Intracellular Membrane-bounded Organelle
Chromatin
Acrosomal Vesicle
Nucleus
Nucleoplasm
Cytosol
Plasma Membrane
Protein Kinase CK2 Complex
PcG Protein Complex
Molecular Function
Damaged DNA Binding
Protein Binding
3'-5' Exonuclease Activity
Exodeoxyribonuclease III Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein N-terminus Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
DNA Damage Checkpoint
DNA Replication
DNA Repair
Cellular Response To DNA Damage Stimulus
Substantia Nigra Development
Meiotic Recombination Checkpoint
Cellular Response To Ionizing Radiation
Nucleic Acid Phosphodiester Bond Hydrolysis
Regulation Of Signal Transduction By P53 Class Mediator
Protein Folding
Phosphatidylcholine Biosynthetic Process
Apoptotic Process
Cell Cycle
Spermatogenesis
Wnt Signaling Pathway
Macroautophagy
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Cerebral Cortex Development
Regulation Of Cell Cycle
Liver Regeneration
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Regulation Of Chromosome Separation
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Apoptotic Signaling Pathway
Pathways
Activation of ATR in response to replication stress
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Synthesis of PC
WNT mediated activation of DVL
Condensation of Prometaphase Chromosomes
Signal transduction by L1
Regulation of TP53 Activity through Phosphorylation
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Receptor Mediated Mitophagy
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN stability and activity
Drugs
[1-(6-{6-[(1-methylethyl)amino]-1H-indazol-1-yl}pyrazin-2-yl)-1H-pyrrol-3-yl]acetic acid
Fostamatinib
Diseases
GWAS
Daytime sleep phenotypes (
27126917
)
Primary biliary cholangitis (
28425483
)
Rosacea symptom severity (
29771307
)
Systemic lupus erythematosus (
28714469
)
Telomere length (
24795349
)
Interacting Genes
24 interacting genes:
COPS5
CSNK2A1
CSNK2A2
DNAJC7
FEN1
HUS1
HUS1B
MAP1LC3B
MSH2
MSH3
MSH6
NEIL1
OGG1
POLB
PRKN
RAD17
RAD9B
RHNO1
RPA1
RPA2
SIRT6
TDG
TOPBP1
WRN
102 interacting genes:
ABCA1
ACACA
ADH1A
AQP4
ARRB2
ASL
ATF1
ATF2
ATG16L1
BHLHE41
BID
CABP1
CALM1
CASQ2
CAV1
CDC37
CLTB
CREBBP
CREM
CSN3
CSNK2B
CTDP1
DCPS
DELEC1
EEF1B2
EIF2B2
EIF2B5
EIF4EBP1
ERCC6
ERH
FGF1
FGF2
FKBP3
FOS
GTF2A1
GTF2A1L
H1-2
HDAC1
HDAC2
HDAC6
HMGA1
HMGA2
HNRNPC
HSP90AA1
HSP90B1
HSPH1
IL16
KDM1A
KIF1C
KLF1
LAMC3
LGALS3
MAF1
MAPK14
MDM2
MGMT
MS4A1
MYC
MYCN
MYF5
NAP1L4
NCL
NR1D2
P4HB
PAK1
PICK1
PIN1
PIN4
PPP1R1B
PPP1R2
PPP1R8
PRNP
PTEN
PTPN1
PTPRC
RAD1
RAD9A
RELA
RGS19
SAT1
SLC18A2
SMURF1
SNCA
SNX6
SPIB
SPP1
STX1A
TCF7L2
TCOF1
TGFBR1
TGM2
TOP1
TP53
TP63
TRIM41
TTLL12
UBE2R2
WAS
XRCC1
ZNF219
ZNF670
ZNHIT3
Entrez ID
5810
1459
HPRD ID
04400
00279
Ensembl ID
ENSG00000113456
ENSG00000070770
Uniprot IDs
A0A024R045
O60671
P19784
PDB IDs
3A1J
3G65
3GGR
6J8Y
3E3B
3OFM
3U87
5M4U
5M56
5OOI
5Y9M
5YF9
5YWM
6HMB
6HMC
6HMD
6HMQ
6L20
6QY8
6QY9
6TE2
6TEW
6TGU
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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