RAD1 and DNAJC7

Data Source:
HPRD (in vitro, in vivo)

		RAD1	DNAJC7
Description		RAD1 checkpoint DNA exonuclease	DnaJ heat shock protein family (Hsp40) member C7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Checkpoint Clamp Complex Intracellular Membrane-bounded Organelle	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Membrane Extracellular Exosome
	Molecular Function	Damaged DNA Binding Protein Binding 3'-5' Exonuclease Activity Exodeoxyribonuclease III Activity	Protein Binding Heat Shock Protein Binding
	Biological Process	DNA Damage Checkpoint DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Substantia Nigra Development Meiotic Recombination Checkpoint Cellular Response To Ionizing Radiation Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Signal Transduction By P53 Class Mediator	Protein Folding Chaperone Cofactor-dependent Protein Refolding Regulation Of Cellular Response To Heat
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint	Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS		Daytime sleep phenotypes ( 27126917)
Interacting Genes		24 interacting genes: COPS5 CSNK2A1 CSNK2A2 DNAJC7 FEN1 HUS1 HUS1B MAP1LC3B MSH2 MSH3 MSH6 NEIL1 OGG1 POLB PRKN RAD17 RAD9B RHNO1 RPA1 RPA2 SIRT6 TDG TOPBP1 WRN	12 interacting genes: DISC1 HSP90AA1 HUS1 MKNK1 NF1 RAD1 RAD9A SMAD2 SMAD9 SMURF1 TP53 UBE4B
Entrez ID		5810	7266
HPRD ID		04400	07046
Ensembl ID		ENSG00000113456	ENSG00000168259
Uniprot IDs		A0A024R045 O60671	Q99615
PDB IDs		3A1J 3G65 3GGR 6J8Y
Enriched GO Terms of Interacting Partners?
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