SYT5 and HTR6

Data Source:
BioGRID (two hybrid)

		SYT5	HTR6
Description		synaptotagmin 5	5-hydroxytryptamine receptor 6
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Axon Synaptic Vesicle Membrane Dense Core Granule Neuronal Cell Body Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Exocytic Vesicle Integral Component Of Neuronal Dense Core Vesicle Membrane Proximal Neuron Projection	Plasma Membrane Integral Component Of Plasma Membrane Cilium Dendrite Synapse
	Molecular Function	SNARE Binding Phosphatidylserine Binding Calcium Ion Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Syntaxin Binding Clathrin Binding Protein Heterodimerization Activity	Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity
	Biological Process	Chemical Synaptic Transmission Regulation Of Dopamine Secretion Vesicle-mediated Transport Calcium-ion Regulated Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Synaptic Vesicle Endocytosis Calcium Ion-regulated Exocytosis Of Neurotransmitter Cellular Response To Calcium Ion	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Cerebral Cortex Cell Migration Positive Regulation Of TOR Signaling G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		Regulation of insulin secretion	Serotonin receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Ziprasidone Amitriptyline Olanzapine Clozapine Loxapine Imipramine Chlorpromazine Haloperidol Amoxapine Paroxetine Cyclobenzaprine Ergoloid mesylate Doxepin Quetiapine Aripiprazole Chlorprothixene Dimethyltryptamine Lysergic acid diethylamide Iloperidone SGS518 PRX-07034 SUVN-502 Sertindole Mianserin Asenapine Zotepine Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Platelet distribution width ( 32888494) Plateletcrit ( 32888494)	Chronotype ( 26955885 27494321) Morning person ( 30696823) Morning vs. evening chronotype ( 26955885 27494321)
Interacting Genes		6 interacting genes: DNAJC5 HTR6 NRXN1 POLR2E RAB1A SYT3	31 interacting genes: ABCA2 ACTB AIP AKR1A1 AP2M1 AP4S1 ATXN10 CHN1 CMSS1 COPS5 DDRGK1 DHRS1 EIF4A3 FYN GNAQ GNAS HDGFL2 IDS MAP1B NF1 NRXN3 PARP8 RUNDC3A SCHIP1 SLC6A1 SRRT SYT5 THY1 TMEM98 TTYH1 UQCRFS1
Entrez ID		6861	3362
HPRD ID		02870	03066
Ensembl ID		ENSG00000129990	ENSG00000158748
Uniprot IDs		A0A024R4N8 O00445 Q4FD32	P50406
PDB IDs		5H4Y 5H4Z
Enriched GO Terms of Interacting Partners?
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