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ELOVL4 and VAPB
Data Source:
BioGRID
(two hybrid)
ELOVL4
VAPB
Description
ELOVL fatty acid elongase 4
VAMP associated protein B and C
Image
No pdb structure
GO Annotations
Cellular Component
Endoplasmic Reticulum
Integral Component Of Endoplasmic Reticulum Membrane
Golgi Membrane
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Plasma Membrane
Integral Component Of Membrane
Endoplasmic Reticulum Exit Site
Molecular Function
Protein Binding
G Protein-coupled Photoreceptor Activity
Fatty Acid Elongase Activity
3-oxo-arachidoyl-CoA Synthase Activity
3-oxo-cerotoyl-CoA Synthase Activity
3-oxo-lignoceronyl-CoA Synthase Activity
Very-long-chain 3-ketoacyl-CoA Synthase Activity
Protein Binding
Microtubule Binding
Enzyme Binding
FFAT Motif Binding
Protein Homodimerization Activity
Cadherin Binding
Protein Heterodimerization Activity
Beta-tubulin Binding
Biological Process
Fatty Acid Biosynthetic Process
Unsaturated Fatty Acid Biosynthetic Process
Detection Of Visible Light
Fatty Acid Elongation, Saturated Fatty Acid
Sphingolipid Biosynthetic Process
Fatty Acid Elongation, Monounsaturated Fatty Acid
Fatty Acid Elongation, Polyunsaturated Fatty Acid
Long-chain Fatty-acyl-CoA Biosynthetic Process
Very Long-chain Fatty Acid Biosynthetic Process
Cellular Calcium Ion Homeostasis
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Endoplasmic Reticulum Organization
Modulation By Virus Of Host Process
Sphingolipid Biosynthetic Process
Endoplasmic Reticulum Unfolded Protein Response
IRE1-mediated Unfolded Protein Response
Positive Regulation Of Viral Genome Replication
Endoplasmic Reticulum-plasma Membrane Tethering
COPII-coated Vesicle Budding
Endoplasmic Reticulum Membrane Organization
Pathways
Synthesis of very long-chain fatty acyl-CoAs
Sphingolipid de novo biosynthesis
Drugs
Omega-3-carboxylic acids
Diseases
Stargardt disease (STGD); Fundus flavimaculatus
Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS
Aging (
22773346
)
Body mass index (
23669352
)
Chronic obstructive pulmonary disease (
28166215
)
Daytime sleep phenotypes (
27126917
)
Macular thickness (
30535121
)
Partial epilepsies (
20522523
)
Interacting Genes
95 interacting genes:
ADGRE2
ANKRD46
APOL3
ATP13A1
BCL2L1
BET1
BIK
BNIP1
BNIP3
BTN2A2
C1GALT1
CCDC167
CCL4L2
CD70
CLCA4
CLDND2
CMTM3
CMTM5
CMTM7
COL4A5
CYB5R3
CYP4F2
ERG28
FA2H
FAM177A1
FAM3C
FAXDC2
FDFT1
FKBP8
FXYD6
GIMAP1
GIMAP5
GOSR2
GPR37L1
GYPA
HMOX1
HMOX2
HSD3B7
IER3IP1
ITGAM
JAGN1
LEPROTL1
LHFPL5
LY6D
MALL
MMP14
NINJ2
ORMDL2
ORMDL3
PKMYT1
PLLP
PLN
PLP1
PTPN1
RAB18
RTP2
SEC22A
SEC22B
SERF1A
SERF1B
SERP2
SFT2D2
SLC30A3
SLC30A8
SNORC
STX3
SYNDIG1
TECR
TF
TMEM11
TMEM128
TMEM19
TMEM199
TMEM203
TMEM218
TMEM222
TMEM242
TMEM243
TMEM254
TMEM42
TMEM44
TRARG1
TREX1
TSNARE1
UBE2J1
UNC50
VAMP1
VAMP3
VAMP4
VAMP5
VAPB
YIF1A
YIPF6
ZDHHC21
ZFPL1
41 interacting genes:
AIG1
AQP2
AQP6
CD79A
CYB561
CYBRD1
EBAG9
EBP
ELOVL4
EMD
FAM174A
GLP1R
GPR25
HSD17B13
JAGN1
KCNB1
MTNR1A
OSBPL2
PTGES
REEP4
RETREG3
RMDN2
RNASEK
RNF111
SCN3B
SLC22A1
SLC35C2
STX1A
STX2
STX4
STX5
TMEM101
TMX2
TTC39B
USP20
VAMP1
VAMP2
VHL
VKORC1
ZBTB22
ZDHHC15
Entrez ID
6785
9217
HPRD ID
05697
09300
Ensembl ID
ENSG00000118402
ENSG00000124164
Uniprot IDs
Q9GZR5
O95292
Q53XM7
PDB IDs
2MDK
3IKK
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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