VAPB and TTC39B

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid)

		VAPB	TTC39B
Description		VAMP associated protein B and C	tetratricopeptide repeat domain 39B
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Membrane Endoplasmic Reticulum Exit Site
	Molecular Function	Protein Binding Microtubule Binding Enzyme Binding FFAT Motif Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Beta-tubulin Binding	Protein Binding
	Biological Process	Cellular Calcium Ion Homeostasis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Modulation By Virus Of Host Process Sphingolipid Biosynthetic Process Endoplasmic Reticulum Unfolded Protein Response IRE1-mediated Unfolded Protein Response Positive Regulation Of Viral Genome Replication Endoplasmic Reticulum-plasma Membrane Tethering COPII-coated Vesicle Budding Endoplasmic Reticulum Membrane Organization	Lipid Metabolic Process Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Cholesterol Homeostasis Regulation Of Cholesterol Metabolic Process
Pathways		Sphingolipid de novo biosynthesis
Drugs
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD) Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS			Alcoholic chronic pancreatitis ( 28754779) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Bipolar disorder ( 22925353) Cholesterol, total ( 24097068 20686565) Coenzyme Q10 levels ( 27149984) Coronary artery disease ( 29212778) Gallstone disease ( 30504769) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol ( 24097068 20864672 19060906 30275531 25961943 20686565) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Hip circumference ( 28552196) Metabolite levels (lipoprotein measures) ( 27005778) Total cholesterol levels ( 28334899) Triglyceride levels ( 32203549) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
Interacting Genes		41 interacting genes: AIG1 AQP2 AQP6 CD79A CYB561 CYBRD1 EBAG9 EBP ELOVL4 EMD FAM174A GLP1R GPR25 HSD17B13 JAGN1 KCNB1 MTNR1A OSBPL2 PTGES REEP4 RETREG3 RMDN2 RNASEK RNF111 SCN3B SLC22A1 SLC35C2 STX1A STX2 STX4 STX5 TMEM101 TMX2 TTC39B USP20 VAMP1 VAMP2 VHL VKORC1 ZBTB22 ZDHHC15	2 interacting genes: MEOX2 VAPB
Entrez ID		9217	158219
HPRD ID		09300	10801
Ensembl ID		ENSG00000124164	ENSG00000155158
Uniprot IDs		O95292 Q53XM7	Q5VTQ0
PDB IDs		2MDK 3IKK
Enriched GO Terms of Interacting Partners?
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