Description |
SRC proto-oncogene, non-receptor tyrosine kinase |
WW domain containing oxidoreductase |
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Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
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Diseases |
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GWAS |
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- Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289)
- Alzheimer's disease (late onset) ( 30820047)
- Anorexia nervosa ( 23568457)
- Bipolar disorder (body mass index interaction) ( 24322204)
- Brain morphology (MOSTest) ( 32665545)
- Brain volume in infants (white matter) ( 28763065)
- Cardiac structure and function ( 19584346)
- Clozapine-induced cytotoxicity ( 25656473)
- Colorectal cancer ( 30529582 29228715)
- Daytime sleep phenotypes ( 27126917)
- Diffusing capacity of carbon monoxide ( 30694715)
- Early-onset Parkinson's disease ( 28256260)
- Eosinophil counts ( 32888494)
- Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678)
- Familial squamous cell lung carcinoma ( 29924316)
- FEV1 ( 30804560)
- Gut microbiota relative abundance (Faecalibacterium) ( 33208821)
- Hematocrit ( 32888494)
- Hemoglobin ( 32888494)
- Hip shape (DXA scan) ( 30320955)
- Idiopathic dilated cardiomyopathy ( 29495422)
- Lung function (forced vital capacity) ( 24929828)
- Lung function (FVC) ( 30804560)
- Lymphocyte counts ( 32888494)
- Macular thickness ( 30535121)
- Metabolite levels ( 23823483)
- Metabolite levels (5-HIAA) ( 23319000)
- Molybdenum levels ( 26025379)
- Monocyte count ( 32888494)
- Multiple sclerosis ( 31604244 24076602)
- Obesity ( 21552555)
- Paclitaxel disposition in epithelial ovarian cancer ( 29367611)
- Peak expiratory flow ( 30804560)
- Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954)
- Platelet count ( 32888494)
- Plateletcrit ( 32888494)
- Post bronchodilator FEV1/FVC ratio ( 26634245)
- Pulmonary function ( 21946350)
- Pulmonary function (smoking interaction) ( 23284291)
- Radiation response ( 20923822)
- Red blood cell count ( 32888494)
- Refractive error ( 32231278)
- Response to amphetamines ( 22952603)
- Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309)
- Response to fenofibrate (HDL cholesterol levels) ( 27002377)
- Serum thyroid-stimulating hormone levels ( 25436638)
- Serum uric acid levels in response to allopurinol in gout ( 25676789)
- Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770)
- Systemic juvenile idiopathic arthritis ( 27927641)
- Type 2 diabetes ( 22158537)
- Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
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Interacting Genes |
300 interacting genes:
ABL1
ACTN1
ADAM12
ADAM15
ADRB2
ADRB3
AFAP1
AFAP1L2
AGAP1
AKT1
ALDOB
ANKRD11
ANXA1
ANXA2
ANXA7
AR
ARHGAP1
ARHGAP17
ARHGAP32
ARHGAP35
ARR3
ASAP1
ATG9A
ATP2B4
AXL
BAAT
BCAR1
BCCIP
BCR
BMX
CA3
CASP8
CAV1
CAV2
CBL
CBLC
CCDC180
CCNA1
CD2AP
CD33
CD36
CD44
CD46
CD59
CDC25A
CDC37
CDCP1
CDH5
CDK1
CDK5
CDKN1B
CEACAM1
CEACAM3
CFL1
CHUK
CLTC
CNTNAP1
COASY
CORO7
CRMP1
CSK
CTNNB1
CTNND1
CTSV
CTTN
DAB1
DAB2
DAG1
DAPP1
DDR2
DGKA
DGKZ
DLG4
DNM1
DNM2
DOK1
DOK2
DOK4
EFNA5
EFNB1
EFNB2
EFS
EGFR
EGLN1
EMD
ENO1
EPHA3
EPHA4
EPHB2
EPS8
ERBB2
ERBB3
ERBB4
ERRFI1
ESR1
ESR2
ETS1
ETS2
EVL
FANCC
FARP2
FASLG
FBP2
FBXO5
FGR
FHIT
FLNA
FLT3
FOXO1
FRS2
FYB1
FZR1
GAB1
GAB2
GAB3
GALNT12
GFAP
GIT1
GJA1
GJB1
GRB10
GRB2
GRIN2A
GRIN2B
GRK2
GTF2I
GUCY2C
HDAC3
HEMGN
HLA-A
HLA-B
HNF1A
HNRNPK
HRAS
HSP90AA1
IGF1R
IKBKB
IKBKG
IL6R
INPPL1
INSR
ITGB3
ITK
JUP
KCNA5
KCNB1
KCNQ5
KDR
KHDRBS1
KIFAP3
KIT
LRP1
LYN
MAP2
MAP2K1
MAPK15
MAPK3
MAPK8IP3
MAPRE1
MAPT
MATK
MDM2
MED28
MET
MICAL1
MPZL1
MST1R
MT-ND2
MUC1
MYLK
NANS
NCOA6
NEDD4
NFKBIA
NMT1
NOS2
NPHS1
NR1I2
NR1I3
NR3C1
P2RY2
PAK2
PDCD6IP
PDE4D
PDE6G
PDGFRB
PDPK1
PECAM1
PELP1
PGR
PIK3R1
PIK3R3
PIP5K1C
PKD1
PLCG1
PLD1
PLD2
PLSCR1
PPARD
PPARGC1B
PPP2CB
PRKACA
PRKCA
PRKCD
PRKCE
PRKCH
PRKCI
PRKCZ
PRKD1
PROM1
PTK2
PTK2B
PTPA
PTPN1
PTPN11
PTPN18
PTPN2
PTPN21
PTPN6
PTPRA
PTPRC
PTPRE
PXN
RACK1
RAF1
RARA
RASA1
RASGRF1
RET
RGS16
RPL10
RPS6KA3
RPS6KB1
RPS6KB2
RXRA
SH2D3C
SH3BP1
SH3PXD2A
SHB
SHC1
SKAP1
SKAP2
SLC9A2
SMARCB1
SMARCE1
SNCA
SORBS1
SPTAN1
SRCIN1
SRF
SRPK2
STAP2
STAT1
STAT3
STAT5A
STAT5B
STAT6
STUB1
STX17
SYK
SYN1
TAMALIN
TERT
THRA
THRB
TIAM1
TMPO
TNFRSF11A
TNFRSF1A
TNK2
TP53
TRAF1
TRAF3
TRAF6
TRAT1
TRIM50
TRIM7
TRIP10
TRIP6
TRMO
TRPC6
TRPV4
TUB
TXK
TYRO3
USP8
VCL
VDR
VIL1
WAS
WASL
WBP11
WWOX
XPA
YTHDC1
YWHAB
YWHAE
YWHAG
YWHAH
ZNF189
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116 interacting genes:
ABHD11
ABI2
ACAT2
ACY1
ADRA2C
ANAPC11
ANXA11
APBB2
ARRDC3
C10orf55
C11orf87
C19orf54
CCDC24
CEACAM6
CLNK
CNNM3
CPSF2
CPSF6
CPSF7
CREB5
CSNK2B
CTAG1A
CTAG1B
CTDSP1
DAZAP2
DMRT3
ENKD1
ERBB4
EZR
FAM214B
FAM222B
FEM1A
FIP1L1
FOXD4L1
FOXI1
FRS3
GCM2
GEM
GLIS2
GNE
HNRNPK
HOXA1
HOXC8
HSPB2
HSPB2-C11orf52
HYAL2
IFIT2
INCA1
KLHDC7B
KLHL38
KRT3
KRT34
KRT75
KRTAP11-1
LASP1
LATS1
LITAF
LMO3
MAPK8
MED25
MKRN3
MYG1
MYOZ1
MYOZ2
NEDD9
NUDT21
OLIG3
OTX1
PATL1
PATZ1
PAX9
PBX4
PEF1
PITX2
PLAC8
PLEKHN1
PLSCR3
PPP1R32
PSMB8
RAMAC
RUSC1
SAXO1
SCAMP3
SEC23IP
SF3B3
SH2D4A
SHC3
SLC15A2
SMAD4
SMR3A
SNRPC
SRC
TCERG1
TCHP
TEKT3
TEX37
TFAP2C
TFG
TNK2
TP53
TP73
TRIM69
TSGA10IP
UBB
UFSP1
VENTX
VEZF1
VPS37C
WDR33
WIPF2
YPEL3
ZBTB32
ZIC1
ZNF135
ZNF414
ZNF581
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Entrez ID |
6714 |
51741 |
HPRD ID |
01819 |
05501 |
Ensembl ID |
ENSG00000197122
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ENSG00000186153
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Uniprot IDs |
P12931
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A0A411HBC7
Q9NZC7
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PDB IDs |
1A07
1A08
1A09
1A1A
1A1B
1A1C
1A1E
1FMK
1HCS
1HCT
1KSW
1O41
1O42
1O43
1O44
1O45
1O46
1O47
1O48
1O49
1O4A
1O4B
1O4C
1O4D
1O4E
1O4F
1O4G
1O4H
1O4I
1O4J
1O4K
1O4L
1O4M
1O4N
1O4O
1O4P
1O4Q
1O4R
1SHD
1Y57
1YI6
1YOJ
1YOL
1YOM
2BDF
2BDJ
2H8H
2SRC
3VRO
3ZMP
3ZMQ
4F59
4F5A
4F5B
4HXJ
4K11
4MXO
4MXX
4MXY
4MXZ
6ATE
6C4S
6E6E
6EHJ
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1WMV
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Enriched GO Terms of Interacting Partners? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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