WWOX and TFAP2C

Data Source:
BioGRID (pull down)

		WWOX	TFAP2C
Description		WW domain containing oxidoreductase	transcription factor AP-2 gamma
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Golgi Apparatus Cytosol Plasma Membrane Microvillus RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Mitochondrion Cytosol
	Molecular Function	Transcription Coactivator Activity Protein Binding Oxidoreductase Activity Enzyme Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Skeletal System Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell-cell Signaling Male Gonad Development Regulation Of Gene Expression, Epigenetic Regulation Of Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Development
Pathways		Nuclear signaling by ERBB4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors	SUMOylation of transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors TFAP2 (AP-2) family regulates transcription of other transcription factors Activation of the TFAP2 (AP-2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors TFAP2 (AP-2) family regulates transcription of cell cycle factors
Drugs
Diseases
GWAS		Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289) Alzheimer's disease (late onset) ( 30820047) Anorexia nervosa ( 23568457) Bipolar disorder (body mass index interaction) ( 24322204) Brain morphology (MOSTest) ( 32665545) Brain volume in infants (white matter) ( 28763065) Cardiac structure and function ( 19584346) Clozapine-induced cytotoxicity ( 25656473) Colorectal cancer ( 30529582 29228715) Daytime sleep phenotypes ( 27126917) Diffusing capacity of carbon monoxide ( 30694715) Early-onset Parkinson's disease ( 28256260) Eosinophil counts ( 32888494) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Familial squamous cell lung carcinoma ( 29924316) FEV1 ( 30804560) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hip shape (DXA scan) ( 30320955) Idiopathic dilated cardiomyopathy ( 29495422) Lung function (forced vital capacity) ( 24929828) Lung function (FVC) ( 30804560) Lymphocyte counts ( 32888494) Macular thickness ( 30535121) Metabolite levels ( 23823483) Metabolite levels (5-HIAA) ( 23319000) Molybdenum levels ( 26025379) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 24076602) Obesity ( 21552555) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Peak expiratory flow ( 30804560) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Platelet count ( 32888494) Plateletcrit ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Radiation response ( 20923822) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to amphetamines ( 22952603) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Serum thyroid-stimulating hormone levels ( 25436638) Serum uric acid levels in response to allopurinol in gout ( 25676789) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770) Systemic juvenile idiopathic arthritis ( 27927641) Type 2 diabetes ( 22158537) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Blond vs. brown/black hair color ( 30531825) Blood urea nitrogen levels ( 31152163) Cerebrospinal P-tau181p levels ( 28247064) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Cognitive decline rate in late mild cognitive impairment ( 26252872) Maximum stenosis ( 32469969) Mean degree of stenosis ( 32469969) Ovarian cancer ( 30557369) Refractive error ( 32231278) Sum of stenosis ( 32469969)
Interacting Genes		116 interacting genes: ABHD11 ABI2 ACAT2 ACY1 ADRA2C ANAPC11 ANXA11 APBB2 ARRDC3 C10orf55 C11orf87 C19orf54 CCDC24 CEACAM6 CLNK CNNM3 CPSF2 CPSF6 CPSF7 CREB5 CSNK2B CTAG1A CTAG1B CTDSP1 DAZAP2 DMRT3 ENKD1 ERBB4 EZR FAM214B FAM222B FEM1A FIP1L1 FOXD4L1 FOXI1 FRS3 GCM2 GEM GLIS2 GNE HNRNPK HOXA1 HOXC8 HSPB2 HSPB2-C11orf52 HYAL2 IFIT2 INCA1 KLHDC7B KLHL38 KRT3 KRT34 KRT75 KRTAP11-1 LASP1 LATS1 LITAF LMO3 MAPK8 MED25 MKRN3 MYG1 MYOZ1 MYOZ2 NEDD9 NUDT21 OLIG3 OTX1 PATL1 PATZ1 PAX9 PBX4 PEF1 PITX2 PLAC8 PLEKHN1 PLSCR3 PPP1R32 PSMB8 RAMAC RUSC1 SAXO1 SCAMP3 SEC23IP SF3B3 SH2D4A SHC3 SLC15A2 SMAD4 SMR3A SNRPC SRC TCERG1 TCHP TEKT3 TEX37 TFAP2C TFG TNK2 TP53 TP73 TRIM69 TSGA10IP UBB UFSP1 VENTX VEZF1 VPS37C WDR33 WIPF2 YPEL3 ZBTB32 ZIC1 ZNF135 ZNF414 ZNF581	12 interacting genes: CCNG1 CITED1 CITED2 CITED4 ERBB4 GPR22 IKBKB NR1I2 TP53 UBE2I WWOX ZFAND4
Entrez ID		51741	7022
HPRD ID		05501	03361
Ensembl ID		ENSG00000186153	ENSG00000087510
Uniprot IDs		A0A411HBC7 Q9NZC7	Q92754
PDB IDs		1WMV
Enriched GO Terms of Interacting Partners?
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