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SRC and DLG4
Data Source:
HPRD
(in vitro, in vivo)
SRC
DLG4
Description
SRC proto-oncogene, non-receptor tyrosine kinase
discs large MAGUK scaffold protein 4
Image
GO Annotations
Cellular Component
Podosome
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Inner Membrane
Lysosome
Late Endosome
Cytosol
Actin Filament
Plasma Membrane
Caveola
Focal Adhesion
Postsynaptic Density
Cell Junction
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Ruffle Membrane
Neuron Projection
Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Glutamatergic Synapse
Postsynaptic Specialization, Intracellular Component
Cytoplasm
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Synaptic Vesicle
Voltage-gated Potassium Channel Complex
Ionotropic Glutamate Receptor Complex
Postsynaptic Density
Cell Junction
Endocytic Vesicle Membrane
Cortical Cytoskeleton
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Neuromuscular Junction
AMPA Glutamate Receptor Complex
Dendrite Cytoplasm
Neuron Projection
Dendritic Spine
Juxtaparanode Region Of Axon
Cerebellar Mossy Fiber
Neuron Projection Terminus
Neuron Spine
Synapse
Postsynaptic Membrane
Excitatory Synapse
Synaptic Membrane
Postsynaptic Density Membrane
Glutamatergic Synapse
Molecular Function
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Kinase C Binding
Signaling Receptor Binding
Insulin Receptor Binding
Integrin Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
Kinase Activity
Enzyme Binding
Kinase Binding
Heme Binding
Estrogen Receptor Binding
Ubiquitin Protein Ligase Binding
SH2 Domain Binding
Ion Channel Binding
Cadherin Binding
Ephrin Receptor Binding
ATPase Binding
Phosphoprotein Binding
BMP Receptor Binding
Growth Factor Receptor Binding
Connexin Binding
Scaffold Protein Binding
Protein Binding
Protein C-terminus Binding
Kinase Binding
Protein Phosphatase Binding
PDZ Domain Binding
Beta-1 Adrenergic Receptor Binding
D1 Dopamine Receptor Binding
P2Y1 Nucleotide Receptor Binding
Acetylcholine Receptor Binding
Ionotropic Glutamate Receptor Binding
Protein-containing Complex Binding
Neuroligin Family Protein Binding
Scaffold Protein Binding
Biological Process
Primary Ovarian Follicle Growth
Stimulatory C-type Lectin Receptor Signaling Pathway
Cell Cycle
Cell Adhesion
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Signal Complex Assembly
Epidermal Growth Factor Receptor Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Axon Guidance
Cell Population Proliferation
Response To Mechanical Stimulus
Response To Virus
Response To Acidic PH
Regulation Of Epithelial Cell Migration
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Glucose Metabolic Process
Positive Regulation Of Protein Processing
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Smooth Muscle Cell Migration
Viral Process
Macroautophagy
Peptidyl-serine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Regulation Of Cell-cell Adhesion
Cell Differentiation
Platelet Activation
Forebrain Development
T Cell Costimulation
Negative Regulation Of Protein-containing Complex Assembly
Protein Destabilization
Response To Nutrient Levels
Positive Regulation Of Protein Autophosphorylation
Activation Of Protein Kinase B Activity
Negative Regulation Of Telomere Maintenance Via Telomerase
Cellular Response To Insulin Stimulus
Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Positive Regulation Of Integrin Activation
Adherens Junction Organization
Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Dephosphorylation
Intracellular Signal Transduction
Entry Of Bacterium Into Host Cell
Osteoclast Development
Cellular Response To Platelet-derived Growth Factor Stimulus
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
ERBB2 Signaling Pathway
Odontogenesis
Response To Drug
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Regulation Of Vascular Permeability
Stress Fiber Assembly
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Protein Binding
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Transcytosis
Innate Immune Response
Regulation Of Bone Resorption
Bone Resorption
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Notch Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Insulin Receptor Signaling Pathway
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Focal Adhesion Assembly
Oogenesis
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Progesterone Receptor Signaling Pathway
Leukocyte Migration
Positive Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Protein Transport
Response To Mineralocorticoid
Response To Electrical Stimulus
Negative Regulation Of Focal Adhesion Assembly
Positive Regulation Of Protein Kinase B Signaling
Negative Regulation Of Mitochondrial Depolarization
Negative Regulation Of Telomerase Activity
Uterus Development
Branching Involved In Mammary Gland Duct Morphogenesis
Regulation Of Cell Projection Assembly
Intestinal Epithelial Cell Development
Interleukin-6-mediated Signaling Pathway
Cellular Response To Hydrogen Peroxide
Positive Regulation Of ERK1 And ERK2 Cascade
Response To Interleukin-1
Cellular Response To Lipopolysaccharide
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Progesterone Stimulus
Cellular Response To Fatty Acid
Cellular Response To Hypoxia
Cellular Response To Fluid Shear Stress
Positive Regulation Of Podosome Assembly
Positive Regulation Of Protein Serine/threonine Kinase Activity
Angiotensin-activated Signaling Pathway Involved In Heart Process
Positive Regulation Of Canonical Wnt Signaling Pathway
Cell-cell Adhesion
Regulation Of Postsynaptic Neurotransmitter Receptor Activity
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity
Positive Regulation Of Ovarian Follicle Development
Positive Regulation Of Lamellipodium Morphogenesis
Positive Regulation Of DNA Biosynthetic Process
Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Regulation Of Early Endosome To Late Endosome Transport
Negative Regulation Of Anoikis
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Regulation Of Caveolin-mediated Endocytosis
MAPK Cascade
Negative Regulation Of Receptor Internalization
Signal Transduction
Positive Regulation Of Cytosolic Calcium Ion Concentration
Chemical Synaptic Transmission
Nervous System Development
Learning
Synaptic Vesicle Maturation
Social Behavior
Protein Localization To Synapse
Locomotory Exploration Behavior
Cellular Response To Potassium Ion
Receptor Clustering
Establishment Of Protein Localization
Regulation Of Long-term Neuronal Synaptic Plasticity
Positive Regulation Of Synaptic Transmission
Neuromuscular Process Controlling Balance
Dendritic Spine Morphogenesis
Positive Regulation Of Protein Tyrosine Kinase Activity
Protein-containing Complex Assembly
Vocalization Behavior
AMPA Glutamate Receptor Clustering
Receptor Localization To Synapse
Cell-cell Adhesion
Postsynaptic Neurotransmitter Receptor Diffusion Trapping
Positive Regulation Of Neuron Projection Arborization
Regulation Of NMDA Receptor Activity
Positive Regulation Of Excitatory Postsynaptic Potential
Regulation Of Grooming Behavior
Pathways
Signaling by ERBB2
Nuclear signaling by ERBB4
Downregulation of ERBB4 signaling
PIP3 activates AKT signaling
GAB1 signalosome
Downstream signal transduction
Constitutive Signaling by Aberrant PI3K in Cancer
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
G alpha (s) signalling events
G alpha (i) signalling events
G alpha (i) signalling events
DCC mediated attractive signaling
DCC mediated attractive signaling
Netrin mediated repulsion signals
Regulation of commissural axon pathfinding by SLIT and ROBO
RAF activation
MAP2K and MAPK activation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates PTK2 signaling
InlA-mediated entry of Listeria monocytogenes into host cells
Regulation of RUNX1 Expression and Activity
RUNX2 regulates osteoblast differentiation
Regulation of RUNX3 expression and activity
Extra-nuclear estrogen signaling
Activated NTRK2 signals through FYN
Activated NTRK3 signals through PI3K
Activated NTRK3 signals through PI3K
Long-term potentiation
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Signaling by ERBB4
Trafficking of AMPA receptors
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
NrCAM interactions
Activation of Ca-permeable Kainate Receptor
RHO GTPases activate CIT
RAF/MAP kinase cascade
LGI-ADAM interactions
Neurexins and neuroligins
Neurexins and neuroligins
Synaptic adhesion-like molecules
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Drugs
Dasatinib
RU84687
RU79256
N6-Benzyl Adenosine-5'-Diphosphate
RU85493
RU78262
Phosphonotyrosine
Malonic acid
RU83876
RU90395
RU79072
RU78783
1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
PASBN
2-[4-[(Z)-2-Acetamido-3-oxo-3-[[(3S)-2-oxo-1-[(4-phenylphenyl)methyl]azepan-3-yl]amino]prop-1-enyl]-2-formylphenyl]acetic acid
PAS219
DPI59
RU82197
Phenylphosphate
RU78300
RU79073
RU82209
ISO24
RU85053
RU78299
Oxalic Acid
RU78191
Citric acid
Paratoulene phosphate
4-[(4-METHYL-1-PIPERAZINYL)METHYL]-N-[3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]PHENYL]-BENZAMIDE
Purvalanol A
XL228
Tirbanibulin
Bosutinib
1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea
1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-phenylurea
3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL
PD-168393
[4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile
PP-121
1-cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1-(1-methylethyl)-3-quinolin-6-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
2-(4-CARCOXY-5-ISOPROPYLTHIAZOLYL)BENZOPIPERIDINE
N-(4-PHENYLAMINO-QUINAZOLIN-6-YL)-ACRYLAMIDE
(2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide
Ponatinib
Nintedanib
Fostamatinib
Guanidine
Guanosine-5'-Monophosphate
Diseases
GWAS
Retinopathy in non-diabetics (
23393555
)
Rheumatoid arthritis (
30891314
)
Squamous cell carcinoma (
26908436
)
Cholesterol, total (
24097068
25961943
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
LDL cholesterol (
24097068
25961943
)
LDL cholesterol levels (
28334899
)
Liver enzyme levels (alkaline phosphatase) (
22001757
)
Serum alkaline phosphatase levels (
29403010
)
Interacting Genes
300 interacting genes:
ABL1
ACTN1
ADAM12
ADAM15
ADRB2
ADRB3
AFAP1
AFAP1L2
AGAP1
AKT1
ALDOB
ANKRD11
ANXA1
ANXA2
ANXA7
AR
ARHGAP1
ARHGAP17
ARHGAP32
ARHGAP35
ARR3
ASAP1
ATG9A
ATP2B4
AXL
BAAT
BCAR1
BCCIP
BCR
BMX
CA3
CASP8
CAV1
CAV2
CBL
CBLC
CCDC180
CCNA1
CD2AP
CD33
CD36
CD44
CD46
CD59
CDC25A
CDC37
CDCP1
CDH5
CDK1
CDK5
CDKN1B
CEACAM1
CEACAM3
CFL1
CHUK
CLTC
CNTNAP1
COASY
CORO7
CRMP1
CSK
CTNNB1
CTNND1
CTSV
CTTN
DAB1
DAB2
DAG1
DAPP1
DDR2
DGKA
DGKZ
DLG4
DNM1
DNM2
DOK1
DOK2
DOK4
EFNA5
EFNB1
EFNB2
EFS
EGFR
EGLN1
EMD
ENO1
EPHA3
EPHA4
EPHB2
EPS8
ERBB2
ERBB3
ERBB4
ERRFI1
ESR1
ESR2
ETS1
ETS2
EVL
FANCC
FARP2
FASLG
FBP2
FBXO5
FGR
FHIT
FLNA
FLT3
FOXO1
FRS2
FYB1
FZR1
GAB1
GAB2
GAB3
GALNT12
GFAP
GIT1
GJA1
GJB1
GRB10
GRB2
GRIN2A
GRIN2B
GRK2
GTF2I
GUCY2C
HDAC3
HEMGN
HLA-A
HLA-B
HNF1A
HNRNPK
HRAS
HSP90AA1
IGF1R
IKBKB
IKBKG
IL6R
INPPL1
INSR
ITGB3
ITK
JUP
KCNA5
KCNB1
KCNQ5
KDR
KHDRBS1
KIFAP3
KIT
LRP1
LYN
MAP2
MAP2K1
MAPK15
MAPK3
MAPK8IP3
MAPRE1
MAPT
MATK
MDM2
MED28
MET
MICAL1
MPZL1
MST1R
MT-ND2
MUC1
MYLK
NANS
NCOA6
NEDD4
NFKBIA
NMT1
NOS2
NPHS1
NR1I2
NR1I3
NR3C1
P2RY2
PAK2
PDCD6IP
PDE4D
PDE6G
PDGFRB
PDPK1
PECAM1
PELP1
PGR
PIK3R1
PIK3R3
PIP5K1C
PKD1
PLCG1
PLD1
PLD2
PLSCR1
PPARD
PPARGC1B
PPP2CB
PRKACA
PRKCA
PRKCD
PRKCE
PRKCH
PRKCI
PRKCZ
PRKD1
PROM1
PTK2
PTK2B
PTPA
PTPN1
PTPN11
PTPN18
PTPN2
PTPN21
PTPN6
PTPRA
PTPRC
PTPRE
PXN
RACK1
RAF1
RARA
RASA1
RASGRF1
RET
RGS16
RPL10
RPS6KA3
RPS6KB1
RPS6KB2
RXRA
SH2D3C
SH3BP1
SH3PXD2A
SHB
SHC1
SKAP1
SKAP2
SLC9A2
SMARCB1
SMARCE1
SNCA
SORBS1
SPTAN1
SRCIN1
SRF
SRPK2
STAP2
STAT1
STAT3
STAT5A
STAT5B
STAT6
STUB1
STX17
SYK
SYN1
TAMALIN
TERT
THRA
THRB
TIAM1
TMPO
TNFRSF11A
TNFRSF1A
TNK2
TP53
TRAF1
TRAF3
TRAF6
TRAT1
TRIM50
TRIM7
TRIP10
TRIP6
TRMO
TRPC6
TRPV4
TUB
TXK
TYRO3
USP8
VCL
VDR
VIL1
WAS
WASL
WBP11
WWOX
XPA
YTHDC1
YWHAB
YWHAE
YWHAG
YWHAH
ZNF189
109 interacting genes:
ACTN2
ADGRB1
ADGRL1
ADRB1
AKAP5
ARHGAP32
ARRB2
ASIC3
ATP2B2
ATP2B4
BEGAIN
CACNG2
CASK
CD46
CIT
CNKSR2
CRHR1
CRIPT
CYLD
DLG2
DLG3
DLGAP1
DLGAP2
DLGAP3
DLGAP4
DYNLL1
EFNB2
ERBB2
ERBB4
ERBIN
EXOC4
FYN
FZD1
FZD2
FZD4
FZD7
GDA
GLS2
GNG13
GRIK1
GRIK2
GRIK5
GRIN1
GRIN2A
GRIN2B
GRIN2C
GRIN2D
GRIN3A
GRIN3B
GUCY1A2
HGS
HTR2A
HTR2C
HTT
IL13RA1
KCNA1
KCNA2
KCNA3
KCNA4
KCNA5
KCND2
KCNJ10
KCNJ12
KCNJ2
KCNJ4
KHDRBS1
KIF13B
KIF1B
LIN7A
LIN7B
LRFN1
LRP1
LRP2
LRP8
LRRC1
LYN
MAP1A
MAP3K10
MAPK12
MDM2
NCKIPSD
NDOR1
NLGN1
NLGN2
NLGN3
NLGN4X
NOS1
PCDH10
PRKCA
PTK2B
PTPRG
RPS6KA1
SCN5A
SEMA4B
SEMA4C
SEMA4F
SEMA4G
SHANK1
SHANK2
SIPA1L1
SPRR2A
SRC
SYNGAP1
TAMALIN
TANC1
TRAF6
WNT3A
YES1
ZDHHC17
Entrez ID
6714
1742
HPRD ID
01819
04199
Ensembl ID
ENSG00000197122
ENSG00000132535
Uniprot IDs
P12931
B7Z4H2
B7Z647
B9EGL1
P78352
PDB IDs
1A07
1A08
1A09
1A1A
1A1B
1A1C
1A1E
1FMK
1HCS
1HCT
1KSW
1O41
1O42
1O43
1O44
1O45
1O46
1O47
1O48
1O49
1O4A
1O4B
1O4C
1O4D
1O4E
1O4F
1O4G
1O4H
1O4I
1O4J
1O4K
1O4L
1O4M
1O4N
1O4O
1O4P
1O4Q
1O4R
1SHD
1Y57
1YI6
1YOJ
1YOL
1YOM
2BDF
2BDJ
2H8H
2SRC
3VRO
3ZMP
3ZMQ
4F59
4F5A
4F5B
4HXJ
4K11
4MXO
4MXX
4MXY
4MXZ
6ATE
6C4S
6E6E
6EHJ
1KEF
2MES
3I4W
3K82
3ZRT
5J7J
5JXB
6QJD
6QJF
6QJG
6QJI
6QJJ
6QJK
6QJL
6QJN
6SPV
6SPZ
Enriched GO Terms of Interacting Partners
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