Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
SRC and STAT5B
Data Source:
HPRD
(in vitro, in vivo)
SRC
STAT5B
Description
SRC proto-oncogene, non-receptor tyrosine kinase
signal transducer and activator of transcription 5B
Image
GO Annotations
Cellular Component
Podosome
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Inner Membrane
Lysosome
Late Endosome
Cytosol
Actin Filament
Plasma Membrane
Caveola
Focal Adhesion
Postsynaptic Density
Cell Junction
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Ruffle Membrane
Neuron Projection
Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Glutamatergic Synapse
Postsynaptic Specialization, Intracellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Kinase C Binding
Signaling Receptor Binding
Insulin Receptor Binding
Integrin Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
Kinase Activity
Enzyme Binding
Kinase Binding
Heme Binding
Estrogen Receptor Binding
Ubiquitin Protein Ligase Binding
SH2 Domain Binding
Ion Channel Binding
Cadherin Binding
Ephrin Receptor Binding
ATPase Binding
Phosphoprotein Binding
BMP Receptor Binding
Growth Factor Receptor Binding
Connexin Binding
Scaffold Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Glucocorticoid Receptor Binding
Identical Protein Binding
Protein Dimerization Activity
Biological Process
Primary Ovarian Follicle Growth
Stimulatory C-type Lectin Receptor Signaling Pathway
Cell Cycle
Cell Adhesion
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Signal Complex Assembly
Epidermal Growth Factor Receptor Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Axon Guidance
Cell Population Proliferation
Response To Mechanical Stimulus
Response To Virus
Response To Acidic PH
Regulation Of Epithelial Cell Migration
Positive Regulation Of Epithelial Cell Migration
Positive Regulation Of Glucose Metabolic Process
Positive Regulation Of Protein Processing
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Smooth Muscle Cell Migration
Viral Process
Macroautophagy
Peptidyl-serine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Regulation Of Cell-cell Adhesion
Cell Differentiation
Platelet Activation
Forebrain Development
T Cell Costimulation
Negative Regulation Of Protein-containing Complex Assembly
Protein Destabilization
Response To Nutrient Levels
Positive Regulation Of Protein Autophosphorylation
Activation Of Protein Kinase B Activity
Negative Regulation Of Telomere Maintenance Via Telomerase
Cellular Response To Insulin Stimulus
Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Positive Regulation Of Integrin Activation
Adherens Junction Organization
Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Dephosphorylation
Intracellular Signal Transduction
Entry Of Bacterium Into Host Cell
Osteoclast Development
Cellular Response To Platelet-derived Growth Factor Stimulus
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
ERBB2 Signaling Pathway
Odontogenesis
Response To Drug
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Regulation Of Vascular Permeability
Stress Fiber Assembly
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Protein Binding
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Transcytosis
Innate Immune Response
Regulation Of Bone Resorption
Bone Resorption
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Notch Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Insulin Receptor Signaling Pathway
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Focal Adhesion Assembly
Oogenesis
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Progesterone Receptor Signaling Pathway
Leukocyte Migration
Positive Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Protein Transport
Response To Mineralocorticoid
Response To Electrical Stimulus
Negative Regulation Of Focal Adhesion Assembly
Positive Regulation Of Protein Kinase B Signaling
Negative Regulation Of Mitochondrial Depolarization
Negative Regulation Of Telomerase Activity
Uterus Development
Branching Involved In Mammary Gland Duct Morphogenesis
Regulation Of Cell Projection Assembly
Intestinal Epithelial Cell Development
Interleukin-6-mediated Signaling Pathway
Cellular Response To Hydrogen Peroxide
Positive Regulation Of ERK1 And ERK2 Cascade
Response To Interleukin-1
Cellular Response To Lipopolysaccharide
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Progesterone Stimulus
Cellular Response To Fatty Acid
Cellular Response To Hypoxia
Cellular Response To Fluid Shear Stress
Positive Regulation Of Podosome Assembly
Positive Regulation Of Protein Serine/threonine Kinase Activity
Angiotensin-activated Signaling Pathway Involved In Heart Process
Positive Regulation Of Canonical Wnt Signaling Pathway
Cell-cell Adhesion
Regulation Of Postsynaptic Neurotransmitter Receptor Activity
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity
Positive Regulation Of Ovarian Follicle Development
Positive Regulation Of Lamellipodium Morphogenesis
Positive Regulation Of DNA Biosynthetic Process
Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Regulation Of Early Endosome To Late Endosome Transport
Negative Regulation Of Anoikis
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Regulation Of Caveolin-mediated Endocytosis
Luteinization
Natural Killer Cell Differentiation
Regulation Of Transcription By RNA Polymerase II
Defense Response
Receptor Signaling Pathway Via JAK-STAT
Female Pregnancy
Lactation
Regulation Of Steroid Metabolic Process
Cytokine-mediated Signaling Pathway
Taurine Metabolic Process
Lipid Storage
Regulation Of Epithelial Cell Differentiation
Response To Estradiol
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Natural Killer Cell Proliferation
Positive Regulation Of Natural Killer Cell Differentiation
Cellular Response To Hormone Stimulus
T Cell Differentiation In Thymus
Interleukin-15-mediated Signaling Pathway
Interleukin-2-mediated Signaling Pathway
Interleukin-7-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Regulation Of Multicellular Organism Growth
Positive Regulation Of Multicellular Organism Growth
Positive Regulation Of Activated T Cell Proliferation
Regulation Of Cell Population Proliferation
Progesterone Metabolic Process
T Cell Homeostasis
Negative Regulation Of Apoptotic Process
Response To Peptide Hormone
Positive Regulation Of B Cell Differentiation
Positive Regulation Of Gamma-delta T Cell Differentiation
Negative Regulation Of Erythrocyte Differentiation
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Development Of Secondary Female Sexual Characteristics
Development Of Secondary Male Sexual Characteristics
Peyer's Patch Development
Positive Regulation Of Inflammatory Response
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Response To Interleukin-4
Cellular Response To Growth Factor Stimulus
Cellular Response To Epidermal Growth Factor Stimulus
Mast Cell Migration
Pathways
Signaling by ERBB2
Nuclear signaling by ERBB4
Downregulation of ERBB4 signaling
PIP3 activates AKT signaling
GAB1 signalosome
Downstream signal transduction
Constitutive Signaling by Aberrant PI3K in Cancer
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
G alpha (s) signalling events
G alpha (i) signalling events
G alpha (i) signalling events
DCC mediated attractive signaling
DCC mediated attractive signaling
Netrin mediated repulsion signals
Regulation of commissural axon pathfinding by SLIT and ROBO
RAF activation
MAP2K and MAPK activation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates PTK2 signaling
InlA-mediated entry of Listeria monocytogenes into host cells
Regulation of RUNX1 Expression and Activity
RUNX2 regulates osteoblast differentiation
Regulation of RUNX3 expression and activity
Extra-nuclear estrogen signaling
Activated NTRK2 signals through FYN
Activated NTRK3 signals through PI3K
Activated NTRK3 signals through PI3K
Long-term potentiation
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Prolactin receptor signaling
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
Signaling by Leptin
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interleukin-3, Interleukin-5 and GM-CSF signaling
Interleukin-20 family signaling
Interleukin-15 signaling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-2 signaling
Interleukin-21 signaling
Erythropoietin activates STAT5
STAT5 Activation
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
STAT5 activation downstream of FLT3 ITD mutants
Signaling by FLT3 fusion proteins
Growth hormone receptor signaling
Growth hormone receptor signaling
Drugs
Dasatinib
RU84687
RU79256
N6-Benzyl Adenosine-5'-Diphosphate
RU85493
RU78262
Phosphonotyrosine
Malonic acid
RU83876
RU90395
RU79072
RU78783
1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
PASBN
2-[4-[(Z)-2-Acetamido-3-oxo-3-[[(3S)-2-oxo-1-[(4-phenylphenyl)methyl]azepan-3-yl]amino]prop-1-enyl]-2-formylphenyl]acetic acid
PAS219
DPI59
RU82197
Phenylphosphate
RU78300
RU79073
RU82209
ISO24
RU85053
RU78299
Oxalic Acid
RU78191
Citric acid
Paratoulene phosphate
4-[(4-METHYL-1-PIPERAZINYL)METHYL]-N-[3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]PHENYL]-BENZAMIDE
Purvalanol A
XL228
Tirbanibulin
Bosutinib
1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea
1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-phenylurea
3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL
PD-168393
[4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile
PP-121
1-cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1-(1-methylethyl)-3-quinolin-6-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
2-(4-CARCOXY-5-ISOPROPYLTHIAZOLYL)BENZOPIPERIDINE
N-(4-PHENYLAMINO-QUINAZOLIN-6-YL)-ACRYLAMIDE
(2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide
Ponatinib
Nintedanib
Fostamatinib
Dasatinib
Diseases
Growth hormone insensitivity with immunodeficiency
GWAS
Retinopathy in non-diabetics (
23393555
)
Rheumatoid arthritis (
30891314
)
Squamous cell carcinoma (
26908436
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
31361310
32296059
)
Asthma (childhood onset) (
31036433
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
27569725
28067908
23128233
)
Lymphocyte counts (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Monocyte count (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Paracentral lobule volume (
31530798
)
Ulcerative colitis (
28067908
)
Interacting Genes
300 interacting genes:
ABL1
ACTN1
ADAM12
ADAM15
ADRB2
ADRB3
AFAP1
AFAP1L2
AGAP1
AKT1
ALDOB
ANKRD11
ANXA1
ANXA2
ANXA7
AR
ARHGAP1
ARHGAP17
ARHGAP32
ARHGAP35
ARR3
ASAP1
ATG9A
ATP2B4
AXL
BAAT
BCAR1
BCCIP
BCR
BMX
CA3
CASP8
CAV1
CAV2
CBL
CBLC
CCDC180
CCNA1
CD2AP
CD33
CD36
CD44
CD46
CD59
CDC25A
CDC37
CDCP1
CDH5
CDK1
CDK5
CDKN1B
CEACAM1
CEACAM3
CFL1
CHUK
CLTC
CNTNAP1
COASY
CORO7
CRMP1
CSK
CTNNB1
CTNND1
CTSV
CTTN
DAB1
DAB2
DAG1
DAPP1
DDR2
DGKA
DGKZ
DLG4
DNM1
DNM2
DOK1
DOK2
DOK4
EFNA5
EFNB1
EFNB2
EFS
EGFR
EGLN1
EMD
ENO1
EPHA3
EPHA4
EPHB2
EPS8
ERBB2
ERBB3
ERBB4
ERRFI1
ESR1
ESR2
ETS1
ETS2
EVL
FANCC
FARP2
FASLG
FBP2
FBXO5
FGR
FHIT
FLNA
FLT3
FOXO1
FRS2
FYB1
FZR1
GAB1
GAB2
GAB3
GALNT12
GFAP
GIT1
GJA1
GJB1
GRB10
GRB2
GRIN2A
GRIN2B
GRK2
GTF2I
GUCY2C
HDAC3
HEMGN
HLA-A
HLA-B
HNF1A
HNRNPK
HRAS
HSP90AA1
IGF1R
IKBKB
IKBKG
IL6R
INPPL1
INSR
ITGB3
ITK
JUP
KCNA5
KCNB1
KCNQ5
KDR
KHDRBS1
KIFAP3
KIT
LRP1
LYN
MAP2
MAP2K1
MAPK15
MAPK3
MAPK8IP3
MAPRE1
MAPT
MATK
MDM2
MED28
MET
MICAL1
MPZL1
MST1R
MT-ND2
MUC1
MYLK
NANS
NCOA6
NEDD4
NFKBIA
NMT1
NOS2
NPHS1
NR1I2
NR1I3
NR3C1
P2RY2
PAK2
PDCD6IP
PDE4D
PDE6G
PDGFRB
PDPK1
PECAM1
PELP1
PGR
PIK3R1
PIK3R3
PIP5K1C
PKD1
PLCG1
PLD1
PLD2
PLSCR1
PPARD
PPARGC1B
PPP2CB
PRKACA
PRKCA
PRKCD
PRKCE
PRKCH
PRKCI
PRKCZ
PRKD1
PROM1
PTK2
PTK2B
PTPA
PTPN1
PTPN11
PTPN18
PTPN2
PTPN21
PTPN6
PTPRA
PTPRC
PTPRE
PXN
RACK1
RAF1
RARA
RASA1
RASGRF1
RET
RGS16
RPL10
RPS6KA3
RPS6KB1
RPS6KB2
RXRA
SH2D3C
SH3BP1
SH3PXD2A
SHB
SHC1
SKAP1
SKAP2
SLC9A2
SMARCB1
SMARCE1
SNCA
SORBS1
SPTAN1
SRCIN1
SRF
SRPK2
STAP2
STAT1
STAT3
STAT5A
STAT5B
STAT6
STUB1
STX17
SYK
SYN1
TAMALIN
TERT
THRA
THRB
TIAM1
TMPO
TNFRSF11A
TNFRSF1A
TNK2
TP53
TRAF1
TRAF3
TRAF6
TRAT1
TRIM50
TRIM7
TRIP10
TRIP6
TRMO
TRPC6
TRPV4
TUB
TXK
TYRO3
USP8
VCL
VDR
VIL1
WAS
WASL
WBP11
WWOX
XPA
YTHDC1
YWHAB
YWHAE
YWHAG
YWHAH
ZNF189
62 interacting genes:
AFTPH
APP
CBL
CD247
CDKN1A
CENPJ
CHAF1A
CRK
CRKL
CTLA4
CXCR4
DMRTA1
EGFR
ELP2
EP300
EPOR
ERBB4
ETS1
ETS2
GHR
HAX1
HNRNPA2B1
IL15
IL2RA
IL2RB
IL7R
INSR
JAK2
JAK3
KIT
LGALS14
LMO4
MAPK1
MED25
MRPS6
NCOR2
NMI
NR3C1
PDGFRA
PDGFRB
PIK3R3
POU2F1
PPP2CA
PTPN1
PTPN11
PTPN2
PTPN6
RARA
RBBP4
SERTAD1
SHC1
SRC
STAC
STAP2
STAT1
STAT3
STAT5A
SUOX
TEK
TFG
TSSK3
USP2
Entrez ID
6714
6777
HPRD ID
01819
05037
Ensembl ID
ENSG00000197122
ENSG00000173757
Uniprot IDs
P12931
P51692
PDB IDs
1A07
1A08
1A09
1A1A
1A1B
1A1C
1A1E
1FMK
1HCS
1HCT
1KSW
1O41
1O42
1O43
1O44
1O45
1O46
1O47
1O48
1O49
1O4A
1O4B
1O4C
1O4D
1O4E
1O4F
1O4G
1O4H
1O4I
1O4J
1O4K
1O4L
1O4M
1O4N
1O4O
1O4P
1O4Q
1O4R
1SHD
1Y57
1YI6
1YOJ
1YOL
1YOM
2BDF
2BDJ
2H8H
2SRC
3VRO
3ZMP
3ZMQ
4F59
4F5A
4F5B
4HXJ
4K11
4MXO
4MXX
4MXY
4MXZ
6ATE
6C4S
6E6E
6EHJ
6MBW
6MBZ
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?