SPINK1 and CTRC

Data Source:
HPRD (in vitro)

		SPINK1	CTRC
Description		serine peptidase inhibitor Kazal type 1	chymotrypsin C
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GO Annotations	Cellular Component	Extracellular Exosome	Extracellular Region
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity
	Biological Process	Negative Regulation Of Nitric Oxide Mediated Signal Transduction Sperm Capacitation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Acrosome Reaction Negative Regulation Of Calcium Ion Import Negative Regulation Of Serine-type Endopeptidase Activity Regulation Of Store-operated Calcium Entry	Proteolysis Cellular Calcium Ion Homeostasis Cobalamin Metabolic Process
Pathways			Cobalamin (Cbl, vitamin B12) transport and metabolism
Drugs
Diseases		Tropical calcific pancreatitis Hereditary pancreatitis; Hereditary chronic pancreatitis	Tropical calcific pancreatitis Hereditary pancreatitis; Hereditary chronic pancreatitis
GWAS		Alcoholic chronic pancreatitis ( 28754779) Blood protein levels ( 30072576) Metabolite levels ( 23823483) Obesity-related traits ( 23251661)	Alcoholic chronic pancreatitis ( 28754779)
Interacting Genes		6 interacting genes: ASPH CTRC ELN NRSN1 TMPRSS15 UBE3A	20 interacting genes: CYSRT1 GIPC2 KRT34 KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP3-1 KRTAP6-2 KRTAP9-2 MDFI NEDD8 NFKBID PHKG1 SERPINA3 SPINK1 ST13 TEX37 UBC VGLL3
Entrez ID		6690	11330
HPRD ID		01341	03242
Ensembl ID		ENSG00000164266	ENSG00000162438
Uniprot IDs		P00995	Q99895
PDB IDs		1CGI 1CGJ 1HPT	4H4F
Enriched GO Terms of Interacting Partners?
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