SPINK1 and NRSN1

Data Source:
HPRD (in vitro)

		SPINK1	NRSN1
Description		serine peptidase inhibitor Kazal type 1	neurensin 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Exosome	Integral Component Of Membrane Transport Vesicle Growth Cone Cytoplasmic Vesicle Neuron Projection Neuronal Cell Body
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of Nitric Oxide Mediated Signal Transduction Sperm Capacitation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Acrosome Reaction Negative Regulation Of Calcium Ion Import Negative Regulation Of Serine-type Endopeptidase Activity Regulation Of Store-operated Calcium Entry	Nervous System Development
Pathways
Drugs
Diseases		Tropical calcific pancreatitis Hereditary pancreatitis; Hereditary chronic pancreatitis
GWAS		Alcoholic chronic pancreatitis ( 28754779) Blood protein levels ( 30072576) Metabolite levels ( 23823483) Obesity-related traits ( 23251661)	Alzheimer's disease in hypertension ( 31055733) Coronary artery disease ( 32469254) Information processing speed ( 21130836) Initial pursuit acceleration ( 29064472) Periodontitis (Mean PAL) ( 24024966) Squamous cell lung carcinoma ( 28604730) Type 2 diabetes ( 31049640)
Interacting Genes		6 interacting genes: ASPH CTRC ELN NRSN1 TMPRSS15 UBE3A	8 interacting genes: FATE1 FCGR1A GPA33 LYVE1 RNF24 SPACA1 SPINK1 TMEM106C
Entrez ID		6690	140767
HPRD ID		01341	18285
Ensembl ID		ENSG00000164266	ENSG00000152954
Uniprot IDs		P00995	Q8IZ57
PDB IDs		1CGI 1CGJ 1HPT
Enriched GO Terms of Interacting Partners?
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