CTRC and SPINK1

Data Source:
HPRD (in vitro)

		CTRC	SPINK1
Description		chymotrypsin C	serine peptidase inhibitor Kazal type 1
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GO Annotations	Cellular Component	Extracellular Region	Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Proteolysis Cellular Calcium Ion Homeostasis Cobalamin Metabolic Process	Negative Regulation Of Nitric Oxide Mediated Signal Transduction Sperm Capacitation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Acrosome Reaction Negative Regulation Of Calcium Ion Import Negative Regulation Of Serine-type Endopeptidase Activity Regulation Of Store-operated Calcium Entry
Pathways		Cobalamin (Cbl, vitamin B12) transport and metabolism
Drugs
Diseases		Tropical calcific pancreatitis Hereditary pancreatitis; Hereditary chronic pancreatitis	Tropical calcific pancreatitis Hereditary pancreatitis; Hereditary chronic pancreatitis
GWAS		Alcoholic chronic pancreatitis ( 28754779)	Alcoholic chronic pancreatitis ( 28754779) Blood protein levels ( 30072576) Metabolite levels ( 23823483) Obesity-related traits ( 23251661)
Interacting Genes		20 interacting genes: CYSRT1 GIPC2 KRT34 KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP3-1 KRTAP6-2 KRTAP9-2 MDFI NEDD8 NFKBID PHKG1 SERPINA3 SPINK1 ST13 TEX37 UBC VGLL3	6 interacting genes: ASPH CTRC ELN NRSN1 TMPRSS15 UBE3A
Entrez ID		11330	6690
HPRD ID		03242	01341
Ensembl ID		ENSG00000162438	ENSG00000164266
Uniprot IDs		Q99895	P00995
PDB IDs		4H4F	1CGI 1CGJ 1HPT
Enriched GO Terms of Interacting Partners?
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