CTRC and SERPINA3

Data Source:
HPRD (in vivo)

		CTRC	SERPINA3
Description		chymotrypsin C	serpin family A member 3
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GO Annotations	Cellular Component	Extracellular Region	Extracellular Region Extracellular Space Nucleus Platelet Alpha Granule Lumen Secretory Granule Lumen Azurophil Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Proteolysis Cellular Calcium Ion Homeostasis Cobalamin Metabolic Process	Platelet Degranulation Acute-phase Response Inflammatory Response Negative Regulation Of Endopeptidase Activity Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium Neutrophil Degranulation
Pathways		Cobalamin (Cbl, vitamin B12) transport and metabolism	Platelet degranulation Neutrophil degranulation
Drugs			Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Tropical calcific pancreatitis Hereditary pancreatitis; Hereditary chronic pancreatitis
GWAS		Alcoholic chronic pancreatitis ( 28754779)	Blood protein levels ( 30072576 28240269) Body mass index ( 23669352) Prostate-specific antigen levels ( 28139693) Serum total protein level ( 29403010)
Interacting Genes		20 interacting genes: CYSRT1 GIPC2 KRT34 KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP3-1 KRTAP6-2 KRTAP9-2 MDFI NEDD8 NFKBID PHKG1 SERPINA3 SPINK1 ST13 TEX37 UBC VGLL3	27 interacting genes: ABCC5 ADAMTS4 ADH1B APP CELA1 CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 KLK13 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 POLR1H SGCD
Entrez ID		11330	12
HPRD ID		03242	00120
Ensembl ID		ENSG00000162438	ENSG00000196136
Uniprot IDs		Q99895	A0A024R6P0 P01011
PDB IDs		4H4F	1AS4 1QMN 2ACH 3CAA 3DLW 4CAA 6HGE
Enriched GO Terms of Interacting Partners?
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