CTRC and NEDD8

Data Source:
BioGRID (enzymatic study)

		CTRC	NEDD8
Description		chymotrypsin C	NEDD8 ubiquitin like modifier
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GO Annotations	Cellular Component	Extracellular Region	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity	Protein Binding Protein Tag Ubiquitin Protein Ligase Binding
	Biological Process	Proteolysis Cellular Calcium Ion Homeostasis Cobalamin Metabolic Process	Regulation Of Transcription By RNA Polymerase II Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Cellular Iron Ion Homeostasis Protein Localization Anatomical Structure Morphogenesis Response To Organic Cyclic Compound Protein Ubiquitination Protein Deubiquitination Modification-dependent Protein Catabolic Process Regulation Of Proteolysis Post-translational Protein Modification Protein Neddylation
Pathways		Cobalamin (Cbl, vitamin B12) transport and metabolism	TGF-beta receptor signaling activates SMADs UCH proteinases Cargo recognition for clathrin-mediated endocytosis Neddylation Iron uptake and transport
Drugs
Diseases		Tropical calcific pancreatitis Hereditary pancreatitis; Hereditary chronic pancreatitis
GWAS		Alcoholic chronic pancreatitis ( 28754779)	Mean corpuscular volume ( 29403010) Systolic blood pressure (cigarette smoking interaction) ( 26752167)
Interacting Genes		20 interacting genes: CYSRT1 GIPC2 KRT34 KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP3-1 KRTAP6-2 KRTAP9-2 MDFI NEDD8 NFKBID PHKG1 SERPINA3 SPINK1 ST13 TEX37 UBC VGLL3	42 interacting genes: AHR ARIH2 ATXN3 CBLB CDC34 COPS5 COPS6 CTRC CUL1 CUL2 CUL3 CUL4B DNMT3B GARS1 GHR HGS HIF1A HSPA4 N4BP1 NAE1 NUB1 OTUB1 OTUD5 PARP1 POLI PSMA6 PSMD4 PTK2 RAD23A SENP8 SMURF1 TP53 UBA2 UBA3 UBE2K UBE2M UBL7 UBQLN1 UBXN7 UCHL1 UCHL3 YAF2
Entrez ID		11330	4738
HPRD ID		03242	04412
Ensembl ID		ENSG00000162438	ENSG00000129559
Uniprot IDs		Q99895	Q15843
PDB IDs		4H4F	1NDD 1R4M 1R4N 1XT9 2BKR 2KO3 2N7K 2NVU 3DBH 3DBL 3DBR 3DQV 3GZN 4F8C 4FBJ 4HCP 4P5O 6R7F 6R7I 6TTU
Enriched GO Terms of Interacting Partners?
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