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SOX4 and TSC1
Data Source:
BioGRID
(fluorescent resonance energy transfer)
SOX4
TSC1
Description
SRY-box transcription factor 4
TSC complex subunit 1
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Mitochondrion
Nucleus
Cytoplasm
Lipid Droplet
Cytosol
Actin Filament
Plasma Membrane
Cell Cortex
Postsynaptic Density
Membrane
Lamellipodium
Growth Cone
Protein-containing Complex
TSC1-TSC2 Complex
Perinuclear Region Of Cytoplasm
Chaperone Complex
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
MiRNA Binding
Sequence-specific Double-stranded DNA Binding
Protein Binding
Hsp70 Protein Binding
GTPase Activating Protein Binding
ATPase Inhibitor Activity
Protein-containing Complex Binding
Protein N-terminus Binding
Chaperone Binding
Hsp90 Protein Binding
Biological Process
Skeletal System Development
Neural Tube Formation
Pro-B Cell Differentiation
Mitral Valve Morphogenesis
Cardiac Ventricle Formation
Cardiac Right Ventricle Morphogenesis
Atrial Septum Primum Morphogenesis
Noradrenergic Neuron Differentiation
Regulation Of Transcription, DNA-templated
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Heart Development
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Anatomical Structure Morphogenesis
Glial Cell Proliferation
Spinal Cord Development
Spinal Cord Motor Neuron Differentiation
Glial Cell Development
Cell Differentiation
T Cell Differentiation
Endocrine Pancreas Development
Negative Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Positive Regulation Of Insulin Secretion
Somatic Stem Cell Population Maintenance
Ascending Aorta Morphogenesis
Glucose Homeostasis
DNA Damage Response, Detection Of DNA Damage
Positive Regulation Of Apoptotic Process
Positive Regulation Of Gamma-delta T Cell Differentiation
Positive Regulation Of Translation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Sympathetic Nervous System Development
Protein Stabilization
Limb Bud Formation
Ventricular Septum Morphogenesis
Negative Regulation Of Cell Death
Neuroepithelial Cell Differentiation
Kidney Morphogenesis
Hematopoietic Stem Cell Homeostasis
Cellular Response To Glucose Stimulus
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of N-terminal Peptidyl-lysine Acetylation
Kidney Development
Neural Tube Closure
Regulation Of Cell-matrix Adhesion
Adaptive Immune Response
RRNA Export From Nucleus
Regulation Of Translation
Potassium Ion Transport
Cell-matrix Adhesion
Negative Regulation Of Cell Population Proliferation
Adult Locomotory Behavior
Negative Regulation Of Neuron Projection Development
Positive Regulation Of Macroautophagy
Negative Regulation Of Macroautophagy
Negative Regulation Of Translation
Hippocampus Development
Cerebral Cortex Development
Cell Projection Organization
Negative Regulation Of TOR Signaling
Negative Regulation Of ATPase Activity
Response To Insulin
Negative Regulation Of GTPase Activity
Myelination
Memory T Cell Differentiation
Regulation Of Phosphoprotein Phosphatase Activity
Negative Regulation Of Cell Size
Regulation Of Protein Kinase Activity
Glucose Import
Negative Regulation Of Insulin Receptor Signaling Pathway
Synapse Organization
Protein Stabilization
Regulation Of Stress Fiber Assembly
Positive Regulation Of Stress Fiber Assembly
Regulation Of Cell Cycle
Positive Regulation Of Focal Adhesion Assembly
Cardiac Muscle Cell Differentiation
Activation Of GTPase Activity
Cellular Response To Oxygen-glucose Deprivation
Regulation Of Neuron Death
Negative Regulation Of Oxidative Stress-induced Neuron Death
Pathways
Deactivation of the beta-catenin transactivating complex
Macroautophagy
Inhibition of TSC complex formation by PKB
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
TBC/RABGAPs
Drugs
Diseases
Lymphangioleiomyomatosis (LAM)
Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS
Bone mineral density (
21533022
)
Cardiac hypertrophy (
21348951
)
Endometrial cancer (
30093612
27008869
)
Endometrial cancer (endometrioid histology) (
30093612
)
Metabolite levels (
23823483
)
Pulmonary function (smoking interaction) (
23284291
)
Migraine without aura (
23793025
)
Psoriasis (
19169254
)
Interacting Genes
34 interacting genes:
AKT1
APOC3
AURKA
CAPN15
CDKN2A
CTR9
DACH1
EDF1
FOXH1
FZR1
IGF1
ITIH1
KRAS
MINPP1
MNT
MYC
NANOGNB
NF1
NF2
NSD3
PLD3
PLXNB1
RGSL1
RHOU
RP1L1
SCNN1G
SDCBP
SMARCA4
STK11
TERT
TNNI3
TSC1
UBE2I
WT1
99 interacting genes:
AKT1
APPL2
AQP1
ARAF
ARID5A
ATXN1
AURKA
BAG3
BECN1
C1orf94
CCDC120
CCL28
CCNB1
CCND2
CCNE1
CDK1
CDK4
CDK6
CDKN2A
CDKN2B
CHCHD2
CSTF2
DMRT3
DOK5
ENKD1
EZR
FAM110A
FAM222B
FGFR4
FOXH1
FRS3
GLIS2
GPANK1
HOXC8
HR
HSH2D
IGFN1
IKBKB
KAT2A
KDM1A
LATS2
LENG1
LMO2
MAP2K5
MAPK14
MSN
MYC
MYLIP
MYOZ3
NEFL
NF2
PATL1
PATZ1
PITX1
PLK1
PLK2
POGZ
POU6F2
PPP1R18
PPP1R32
PRMT6
RASSF1
RBPMS
RDX
RHEB
RIN1
RIN3
SAMD11
SAMD7
SH2D2A
SHC3
SMG9
SOX4
SPAG8
SUOX
TBC1D7
TBX6
TCF7L2
TFAP2D
TLE5
TNS2
TSC2
TSGA10IP
TSHZ3
VENTX
VEZF1
VGLL3
VPS37C
YPEL3
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZIC1
ZNF417
ZNF587
ZNF765
Entrez ID
6659
7248
HPRD ID
01695
05594
Ensembl ID
ENSG00000124766
ENSG00000165699
Uniprot IDs
Q06945
A0A2R8Y5S3
Q32NF0
Q86WV8
Q92574
X5D9D2
PDB IDs
4Z6Y
5EJC
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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