SOX4 and CTR9

Data Source:
BioGRID (two hybrid)

		SOX4	CTR9
Description		SRY-box transcription factor 4	CTR9 homolog, Paf1/RNA polymerase II complex component
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion	Nucleoplasm Cdc73/Paf1 Complex Nuclear Speck Transcriptionally Active Chromatin
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding MiRNA Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Complex Binding Protein Binding SH2 Domain Binding
	Biological Process	Skeletal System Development Neural Tube Formation Pro-B Cell Differentiation Mitral Valve Morphogenesis Cardiac Ventricle Formation Cardiac Right Ventricle Morphogenesis Atrial Septum Primum Morphogenesis Noradrenergic Neuron Differentiation Regulation Of Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Glial Cell Proliferation Spinal Cord Development Spinal Cord Motor Neuron Differentiation Glial Cell Development Cell Differentiation T Cell Differentiation Endocrine Pancreas Development Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Positive Regulation Of Insulin Secretion Somatic Stem Cell Population Maintenance Ascending Aorta Morphogenesis Glucose Homeostasis DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Apoptotic Process Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Translation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Protein Stabilization Limb Bud Formation Ventricular Septum Morphogenesis Negative Regulation Of Cell Death Neuroepithelial Cell Differentiation Kidney Morphogenesis Hematopoietic Stem Cell Homeostasis Cellular Response To Glucose Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of N-terminal Peptidyl-lysine Acetylation	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Commitment Inner Cell Mass Cell Differentiation Trophectodermal Cell Differentiation Blastocyst Growth Blastocyst Hatching Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Receptor Signaling Pathway Via JAK-STAT Histone Monoubiquitination Wnt Signaling Pathway Protein Ubiquitination Stem Cell Population Maintenance Histone H2B Ubiquitination Negative Regulation Of Myeloid Cell Differentiation Regulation Of Histone H3-K4 Methylation Positive Regulation Of Histone H3-K4 Methylation Interleukin-6-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Histone H3-K4 Trimethylation Negative Regulation Of MRNA Polyadenylation Regulation Of Genetic Imprinting Positive Regulation Of Histone H3-K79 Methylation Positive Regulation Of Histone H2B Ubiquitination
Pathways		Deactivation of the beta-catenin transactivating complex	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Bone mineral density ( 21533022) Cardiac hypertrophy ( 21348951) Endometrial cancer ( 30093612 27008869) Endometrial cancer (endometrioid histology) ( 30093612) Metabolite levels ( 23823483) Pulmonary function (smoking interaction) ( 23284291)	Migraine ( 27182965)
Interacting Genes		34 interacting genes: AKT1 APOC3 AURKA CAPN15 CDKN2A CTR9 DACH1 EDF1 FOXH1 FZR1 IGF1 ITIH1 KRAS MINPP1 MNT MYC NANOGNB NF1 NF2 NSD3 PLD3 PLXNB1 RGSL1 RHOU RP1L1 SCNN1G SDCBP SMARCA4 STK11 TERT TNNI3 TSC1 UBE2I WT1	7 interacting genes: BLK CNTNAP2 H1-2 SMAD9 SOX4 SUMO2 TCEA1
Entrez ID		6659	9646
HPRD ID		01695	06717
Ensembl ID		ENSG00000124766	ENSG00000198730
Uniprot IDs		Q06945	Q6PD62
PDB IDs			5ZYQ 6GMH 6TED
Enriched GO Terms of Interacting Partners?
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