PLEKHG2 and ACTN3

Data Source:
BioGRID (two hybrid)

		PLEKHG2	ACTN3
Description		pleckstrin homology and RhoGEF domain containing G2	actinin alpha 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Cytosol Actin Filament Focal Adhesion Pseudopodium Extracellular Exosome
	Molecular Function	Protein Binding	Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Identical Protein Binding Ion Channel Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Regulation Of Actin Filament Polymerization Positive Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction	Regulation Of The Force Of Skeletal Muscle Contraction Skeletal Muscle Atrophy Transition Between Fast And Slow Fiber Response To Denervation Involved In Regulation Of Muscle Adaptation Muscle Filament Sliding Regulation Of Apoptotic Process Negative Regulation Of Glycolytic Process Focal Adhesion Assembly Positive Regulation Of Skeletal Muscle Tissue Growth Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Cold-induced Thermogenesis Regulation Of Aerobic Respiration Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events	Nephrin family interactions Striated Muscle Contraction
Drugs
Diseases
GWAS			Bipolar disorder ( 21926972) Frontotemporal dementia with GRN mutation ( 29724592)
Interacting Genes		8 interacting genes: ACTN3 APP CDC42 GNG2 PIN1 RAC1 RHOA XRN1	61 interacting genes: ABI3 ACTN1 ACTN2 ACTN4 ADORA2A ASB9 ATP23 BRCA1 C1orf94 C20orf85 C2CD6 CADPS CTAG1A CTAG1B CTDSP1 CXCL5 DDAH2 DUX1 DUX4L9 ECM1 FAM90A1 GLIS2 HGS HOXD12 HSF2BP IVD KCTD6 KRT6C LHX3 LINC01554 LNX1 MAGEA6 MICALL2 MYOT MYOZ1 MYPN NDUFAB1 NEBL NKAPD1 NRAP ODF3B PCCB PKP2 PLEKHG2 POU6F2 PPP1R18 PTK6 REL RNF111 RTP5 SNAI1 SOHLH1 SUMO1P1 SYNPO2L TRAF1 TRAF2 TRIM29 TTN USP2 ZNF343 ZNF426
Entrez ID		64857	89
HPRD ID		15148	02148
Ensembl ID		ENSG00000090924	ENSG00000248746
Uniprot IDs		Q9H7P9	A0A087WSZ2 B4DZQ2 Q08043
PDB IDs			1TJT 1WKU 3LUE
Enriched GO Terms of Interacting Partners?
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