ACTN3 and MICALL2

Data Source:
BioGRID (two hybrid)

		ACTN3	MICALL2
Description		actinin alpha 3	MICAL like 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Actin Filament Focal Adhesion Pseudopodium Extracellular Exosome	Stress Fiber Cytosol Plasma Membrane Cell-cell Junction Bicellular Tight Junction Actin Filament Bundle Neuron Projection Recycling Endosome
	Molecular Function	Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Identical Protein Binding Ion Channel Binding	Protein Binding Filamin Binding Small GTPase Binding Actinin Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Regulation Of The Force Of Skeletal Muscle Contraction Skeletal Muscle Atrophy Transition Between Fast And Slow Fiber Response To Denervation Involved In Regulation Of Muscle Adaptation Muscle Filament Sliding Regulation Of Apoptotic Process Negative Regulation Of Glycolytic Process Focal Adhesion Assembly Positive Regulation Of Skeletal Muscle Tissue Growth Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Cold-induced Thermogenesis Regulation Of Aerobic Respiration Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate	Actin Filament Polymerization Neuron Projection Development Actin Cytoskeleton Reorganization Endocytic Recycling Substrate Adhesion-dependent Cell Spreading Bicellular Tight Junction Assembly Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Nephrin family interactions Striated Muscle Contraction
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972) Frontotemporal dementia with GRN mutation ( 29724592)	Blood urea nitrogen levels ( 29403010) Creatinine levels ( 29403010) Executive inhibition (Stroop WIT and CIT) in attention deficit hyperactivity disorder ( 28416812) Glomerular filtration rate ( 29403010) Hematocrit ( 29403010) Hemoglobin ( 29403010) Red blood cell count ( 29403010) Resistance to antihypertensive treatment in hypertension ( 31545351) Serum uric acid levels ( 30993211 29403010) Zinc levels ( 26025379)
Interacting Genes		61 interacting genes: ABI3 ACTN1 ACTN2 ACTN4 ADORA2A ASB9 ATP23 BRCA1 C1orf94 C20orf85 C2CD6 CADPS CTAG1A CTAG1B CTDSP1 CXCL5 DDAH2 DUX1 DUX4L9 ECM1 FAM90A1 GLIS2 HGS HOXD12 HSF2BP IVD KCTD6 KRT6C LHX3 LINC01554 LNX1 MAGEA6 MICALL2 MYOT MYOZ1 MYPN NDUFAB1 NEBL NKAPD1 NRAP ODF3B PCCB PKP2 PLEKHG2 POU6F2 PPP1R18 PTK6 REL RNF111 RTP5 SNAI1 SOHLH1 SUMO1P1 SYNPO2L TRAF1 TRAF2 TRIM29 TTN USP2 ZNF343 ZNF426	6 interacting genes: ACTN1 ACTN2 ACTN3 ACTN4 CDR2 DCDC2
Entrez ID		89	79778
HPRD ID		02148	11364
Ensembl ID		ENSG00000248746	ENSG00000164877
Uniprot IDs		A0A087WSZ2 B4DZQ2 Q08043	Q6UWK3 Q8IY33
PDB IDs		1TJT 1WKU 3LUE
Enriched GO Terms of Interacting Partners?
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