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ACTN3 and PTK6
Data Source:
BioGRID
(two hybrid)
ACTN3
PTK6
Description
actinin alpha 3
protein tyrosine kinase 6
Image
GO Annotations
Cellular Component
Cytosol
Actin Filament
Focal Adhesion
Pseudopodium
Extracellular Exosome
Ruffle
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Nuclear Body
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Molecular Function
Actin Binding
Integrin Binding
Calcium Ion Binding
Protein Binding
Structural Constituent Of Muscle
Identical Protein Binding
Ion Channel Binding
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Identical Protein Binding
Biological Process
Regulation Of The Force Of Skeletal Muscle Contraction
Skeletal Muscle Atrophy
Transition Between Fast And Slow Fiber
Response To Denervation Involved In Regulation Of Muscle Adaptation
Muscle Filament Sliding
Regulation Of Apoptotic Process
Negative Regulation Of Glycolytic Process
Focal Adhesion Assembly
Positive Regulation Of Skeletal Muscle Tissue Growth
Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Negative Regulation Of Oxidative Phosphorylation
Negative Regulation Of Cold-induced Thermogenesis
Regulation Of Aerobic Respiration
Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate
Protein Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Tyrosine Phosphorylation Of STAT Protein
Negative Regulation Of Signal Transduction
Positive Regulation Of Neuron Projection Development
Cell Migration
Cell Differentiation
ERBB2 Signaling Pathway
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Innate Immune Response
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cell Cycle
Negative Regulation Of Growth
Protein Autophosphorylation
Intestinal Epithelial Cell Differentiation
Negative Regulation Of Protein Tyrosine Kinase Activity
Cellular Response To Retinoic Acid
Pathways
Nephrin family interactions
Striated Muscle Contraction
SCF(Skp2)-mediated degradation of p27/p21
Cyclin D associated events in G1
ERBB2 Activates PTK6 Signaling
PTK6 Regulates Proteins Involved in RNA Processing
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
PTK6 Regulates Cell Cycle
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
PTK6 Down-Regulation
PTK6 Expression
PTK6 Activates STAT3
PTK6 promotes HIF1A stabilization
Drugs
Vandetanib
Fostamatinib
Zanubrutinib
Diseases
GWAS
Bipolar disorder (
21926972
)
Frontotemporal dementia with GRN mutation (
29724592
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
31043756
)
Bipolar I disorder (
31043756
)
Hair shape (
29220522
)
Prostate cancer (
23535732
)
Interacting Genes
61 interacting genes:
ABI3
ACTN1
ACTN2
ACTN4
ADORA2A
ASB9
ATP23
BRCA1
C1orf94
C20orf85
C2CD6
CADPS
CTAG1A
CTAG1B
CTDSP1
CXCL5
DDAH2
DUX1
DUX4L9
ECM1
FAM90A1
GLIS2
HGS
HOXD12
HSF2BP
IVD
KCTD6
KRT6C
LHX3
LINC01554
LNX1
MAGEA6
MICALL2
MYOT
MYOZ1
MYPN
NDUFAB1
NEBL
NKAPD1
NRAP
ODF3B
PCCB
PKP2
PLEKHG2
POU6F2
PPP1R18
PTK6
REL
RNF111
RTP5
SNAI1
SOHLH1
SUMO1P1
SYNPO2L
TRAF1
TRAF2
TRIM29
TTN
USP2
ZNF343
ZNF426
35 interacting genes:
ACTN3
ANKRD55
APP
AR
CBLB
CCDC33
DDX17
DOK1
DTX3
EFHC2
EGFR
ERBB2
ERBB3
ERBB4
EXOC5
FCHO1
FGFR1
GAB1
HIF1A
KHDRBS1
KHDRBS2
KIAA1217
KIT
LINC01139
MEIS2
MET
MKRN3
MYOZ3
PITX1
PRDM6
REL
SLA
STAP2
WASL
ZNF341
Entrez ID
89
5753
HPRD ID
02148
03594
Ensembl ID
ENSG00000248746
ENSG00000101213
Uniprot IDs
A0A087WSZ2
B4DZQ2
Q08043
Q13882
PDB IDs
1TJT
1WKU
3LUE
1RJA
2KGT
5D7V
5DA3
5H2U
6CZ2
6CZ3
6CZ4
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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