PALS1 and NEK9

Data Source:
BioGRID (affinity chromatography technology)

		PALS1	NEK9
Description		protein associated with LIN7 1, MAGUK family member	NIMA related kinase 9
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Plasma Membrane Adherens Junction Bicellular Tight Junction Apical Plasma Membrane Axon Protein-containing Complex Myelin Sheath Adaxonal Region Perikaryon Lateral Loop Schmidt-Lanterman Incisure Extracellular Exosome	Nucleus Centrosome Cytosol
	Molecular Function	Protein Binding ATP Binding Protein Domain Specific Binding	Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Morphogenesis Of An Epithelial Sheet Gene Expression Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Central Nervous System Neuron Development Cerebral Cortex Development Peripheral Nervous System Myelin Maintenance Myelin Assembly Protein Localization To Myelin Sheath Abaxonal Region Bicellular Tight Junction Assembly Protein Localization To Plasma Membrane	Protein Phosphorylation Mitotic Nuclear Envelope Disassembly Cell Division
Pathways		Tight junction interactions	Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation
Drugs			Fostamatinib
Diseases
GWAS			Coronary artery disease ( 29212778) Feeling fed-up ( 29500382)
Interacting Genes		16 interacting genes: ARF6 BHLHB9 CRB3 DLGAP4 FTCD LIN7A LIN7B LIN7C MPP4 NUMB PARD6B PATJ SNTG2 SOCS4 SRGAP2B TRAF2	10 interacting genes: BICD2 CSN2 MBP NEK6 NEK7 NEK8 RAN SSRP1 SUPT16H TTN
Entrez ID		64398	91754
HPRD ID		09508	11386
Ensembl ID		ENSG00000072415	ENSG00000119638
Uniprot IDs		Q658X5 Q8N3R9	Q6PKF2 Q8TD19
PDB IDs		1Y76 3UIT 4UU5 4UU6 4WSI	3ZKE 3ZKF
Enriched GO Terms of Interacting Partners?
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