PALS1 and LIN7A

Data Source:
HPRD (in vitro)

		PALS1	LIN7A
Description		protein associated with LIN7 1, MAGUK family member	lin-7 homolog A, crumbs cell polarity complex component
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Plasma Membrane Adherens Junction Bicellular Tight Junction Apical Plasma Membrane Axon Protein-containing Complex Myelin Sheath Adaxonal Region Perikaryon Lateral Loop Schmidt-Lanterman Incisure Extracellular Exosome	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Basolateral Plasma Membrane Synapse Extracellular Exosome MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane
	Molecular Function	Protein Binding ATP Binding Protein Domain Specific Binding	Protein Binding L27 Domain Binding
	Biological Process	Morphogenesis Of An Epithelial Sheet Gene Expression Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Central Nervous System Neuron Development Cerebral Cortex Development Peripheral Nervous System Myelin Maintenance Myelin Assembly Protein Localization To Myelin Sheath Abaxonal Region Bicellular Tight Junction Assembly Protein Localization To Plasma Membrane	Exocytosis Neurotransmitter Secretion Protein Transport Maintenance Of Epithelial Cell Apical/basal Polarity Synaptic Vesicle Transport Inner Ear Development Protein-containing Complex Assembly Protein Localization To Basolateral Plasma Membrane
Pathways		Tight junction interactions	Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors
Drugs
Diseases
GWAS			Age-related cataracts (age at onset) ( 25352737) Dental caries ( 23259602)
Interacting Genes		16 interacting genes: ARF6 BHLHB9 CRB3 DLGAP4 FTCD LIN7A LIN7B LIN7C MPP4 NUMB PARD6B PATJ SNTG2 SOCS4 SRGAP2B TRAF2	24 interacting genes: ABCA1 ADGRB1 APP BAIAP2 CASK CHRD DLG2 DLG3 DLG4 DNAJC5 ECM1 FAM9B GOLGA2 GRIN2B KCNJ12 MDFI MPP2 MPP3 MPP7 NOTCH2NLA PALS1 PALS2 SLC6A12 ZYX
Entrez ID		64398	8825
HPRD ID		09508	04542
Ensembl ID		ENSG00000072415	ENSG00000111052
Uniprot IDs		Q658X5 Q8N3R9	O14910
PDB IDs		1Y76 3UIT 4UU5 4UU6 4WSI
Enriched GO Terms of Interacting Partners?
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