NEK9 and SUPT16H

Data Source:
HPRD (in vivo)

		NEK9	SUPT16H
Description		NIMA related kinase 9	SPT16 homolog, facilitates chromatin remodeling subunit
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GO Annotations	Cellular Component	Nucleus Centrosome Cytosol	Nucleoplasm FACT Complex
	Molecular Function	Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	RNA Binding Protein Binding Nucleosome Binding
	Biological Process	Protein Phosphorylation Mitotic Nuclear Envelope Disassembly Cell Division	DNA Replication DNA Repair Nucleosome Disassembly Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Viral Process Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter DNA Replication-independent Nucleosome Organization Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation	Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Transcription Elongation
Drugs		Fostamatinib
Diseases
GWAS		Coronary artery disease ( 29212778) Feeling fed-up ( 29500382)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		10 interacting genes: BICD2 CSN2 MBP NEK6 NEK7 NEK8 RAN SSRP1 SUPT16H TTN	13 interacting genes: CCT6A GTF2E2 H2AC13 H2AX H3-3A MCM3 MCM4 NEK9 PARP1 SREK1 SRPK2 SSRP1 SUMO2
Entrez ID		91754	11198
HPRD ID		11386	16088
Ensembl ID		ENSG00000119638	ENSG00000092201
Uniprot IDs		Q6PKF2 Q8TD19	Q9Y5B9
PDB IDs		3ZKE 3ZKF	4Z2M 4Z2N 5E5B 5UMT 5UMU 5XM2 6UPK 6UPL
Enriched GO Terms of Interacting Partners?
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