Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
PALS1 and NUMB
Data Source:
BioGRID
(two hybrid)
PALS1
NUMB
Description
protein associated with LIN7 1, MAGUK family member
NUMB endocytic adaptor protein
Image
GO Annotations
Cellular Component
Cytoplasm
Endoplasmic Reticulum-Golgi Intermediate Compartment
Golgi Apparatus
Plasma Membrane
Adherens Junction
Bicellular Tight Junction
Apical Plasma Membrane
Axon
Protein-containing Complex
Myelin Sheath Adaxonal Region
Perikaryon
Lateral Loop
Schmidt-Lanterman Incisure
Extracellular Exosome
Nucleus
Cytoplasm
Early Endosome
Plasma Membrane
Clathrin-coated Pit
Focal Adhesion
Endosome Membrane
Basolateral Plasma Membrane
Extrinsic Component Of Plasma Membrane
Clathrin-coated Vesicle
Apical Part Of Cell
Glutamatergic Synapse
Molecular Function
Protein Binding
ATP Binding
Protein Domain Specific Binding
Protein Binding
Beta-catenin Binding
Alpha-catenin Binding
Cadherin Binding
Biological Process
Morphogenesis Of An Epithelial Sheet
Gene Expression
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Central Nervous System Neuron Development
Cerebral Cortex Development
Peripheral Nervous System Myelin Maintenance
Myelin Assembly
Protein Localization To Myelin Sheath Abaxonal Region
Bicellular Tight Junction Assembly
Protein Localization To Plasma Membrane
Axonogenesis
Lateral Ventricle Development
Neuroblast Division In Subventricular Zone
Positive Regulation Of Cell Migration
Adherens Junction Organization
Positive Regulation Of Neurogenesis
Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Negative Regulation Of Protein Localization To Plasma Membrane
Pathways
Tight junction interactions
Activated NOTCH1 Transmits Signal to the Nucleus
Recycling pathway of L1
Degradation of GLI1 by the proteasome
Hedgehog 'on' state
Drugs
Diseases
GWAS
Bipolar disorder with mood-incongruent psychosis (
23092984
)
Coronary artery calcification (
17903303
)
Hemoglobin (
32888494
)
Macular thickness (
30535121
)
Multisite chronic pain (
31194737
)
Interacting Genes
16 interacting genes:
ARF6
BHLHB9
CRB3
DLGAP4
FTCD
LIN7A
LIN7B
LIN7C
MPP4
NUMB
PARD6B
PATJ
SNTG2
SOCS4
SRGAP2B
TRAF2
37 interacting genes:
AP2A1
AP2A2
APP
DNAJC5
DPYSL2
EAF1
EGFR
EPS15
FBXO7
FRS3
IRS1
ITCH
ITGB2
ITGB3
ITGB5
L1CAM
LNX1
LNX2
MAPK8IP2
MDM2
NEDD4
NOTCH1
OLIG1
PALS1
PDZK1IP1
PRKCA
PRKCB
PRKCD
PRKCE
PRKCG
PRKCH
PRKCZ
PTEN
RPL3
SIAH1
SPANXN2
TERF2
Entrez ID
64398
8650
HPRD ID
09508
04767
Ensembl ID
ENSG00000072415
ENSG00000133961
Uniprot IDs
Q658X5
Q8N3R9
A0A024R681
A0A024R684
A0A024R6C4
A0A024R6F4
P49757
PDB IDs
1Y76
3UIT
4UU5
4UU6
4WSI
5NJJ
5NJK
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?