PCCA and PJA1

Data Source:
BioGRID (enzymatic study)

		PCCA	PJA1
Description		propionyl-CoA carboxylase subunit alpha	praja ring finger ubiquitin ligase 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Cytosol	Cytoplasm
	Molecular Function	Propionyl-CoA Carboxylase Activity Protein Binding ATP Binding Biotin Binding CoA Carboxylase Activity Enzyme Binding Metal Ion Binding	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Biotin Metabolic Process Short-chain Fatty Acid Catabolic Process	Protein Ubiquitination Protein Catabolic Process
Pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency Propionyl-CoA catabolism	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Biotin
Diseases		Propionic acidemia
GWAS		Chromosomal aberration frequency (chromatid type) in genotoxic compound exposure ( 31586183) Corpus callosum anterior volume ( 31530798) Metabolite levels ( 23823483) Myopia ( 27182965) Refractive error ( 23396134 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation (ever regular vs never regular) ( 30679032) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Birth weight ( 31043758) Body mass index ( 29273807) Platelet count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		4 interacting genes: ERRFI1 MCC PCCB PJA1	64 interacting genes: ABR ASCC2 ATP5F1C ATXN3 ATXN3L CAMK1G CDK16 COASY CSAG3 DDX54 EED ELAC1 ESPL1 EZH2 FGF12 GATD3A GLO1 GSR GTF2I HNRNPC HNRNPL HOMER2 JOSD1 KIF22 LCP2 LRG1 MAGEB4 MAGED1 MDM2 METAP2 NAGK NATD1 NDN OTUB1 OTUB2 PCCA PFKFB4 PHGDH PIP4K2C RIBC2 SPTBN1 STAC STAM STAMBP SUZ12 TAF9 TK1 TMEM214 TSSK3 TXNDC5 UBE2D2 UBE2D3 UBE2E3 UBE2K UBE2L3 UBE2U UCHL3 UCHL5 USP20 USP28 USP5 USP51 USP8 ZNF440
Entrez ID		5095	64219
HPRD ID		01981	02335
Ensembl ID		ENSG00000175198	ENSG00000181191
Uniprot IDs		P05165	Q8NG27
PDB IDs		2CQY 2JKU	2L0B
Enriched GO Terms of Interacting Partners?
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