SCP2 and EHHADH

Data Source:
HPRD (in vitro)

		SCP2	EHHADH
Description		sterol carrier protein 2	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Peroxisome Peroxisomal Matrix Cytosol Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle	Peroxisome Peroxisomal Matrix Cytosol
	Molecular Function	Fatty-acyl-CoA Binding Acetyl-CoA C-acyltransferase Activity Signaling Receptor Binding Protein Binding Cholesterol Binding Sterol Binding Propanoyl-CoA C-acyltransferase Activity Long-chain Fatty Acyl-CoA Binding Propionyl-CoA C2-trimethyltridecanoyltransferase Activity Acetyl-CoA C-myristoyltransferase Activity Oleic Acid Binding	3-hydroxyacyl-CoA Dehydrogenase Activity Dodecenoyl-CoA Delta-isomerase Activity Enoyl-CoA Hydratase Activity Protein Binding Long-chain-enoyl-CoA Hydratase Activity Long-chain-3-hydroxyacyl-CoA Dehydrogenase Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds Enzyme Binding
	Biological Process	Protein Targeting To Peroxisome Fatty Acid Beta-oxidation Steroid Biosynthetic Process Bile Acid Biosynthetic Process Bile Acid Metabolic Process Phospholipid Transport Positive Regulation Of Intracellular Cholesterol Transport Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Lipid Hydroperoxide Transport	Protein Targeting To Peroxisome Fatty Acid Beta-oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase
Pathways		alpha-linolenic acid (ALA) metabolism Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins	Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import
Drugs			NADH
Diseases		Peroxisomal beta-oxidation enzyme deficiency, including: Acyl-CoA oxidase (ACOX) deficiency; D-bifunctional protein (DBP) deficiency; Perrault syndrome; Sterol carrier protein X (SCPx) deficiency; 2-Methylacyl-CoA racemase (AMCR) deficiency; Hypercholanemia Leukoencephalopathy with dystonia and motor neuropathy
GWAS			Cognitive performance ( 19734545) Major depressive disorder ( 27519822 21042317)
Interacting Genes		9 interacting genes: ACAA2 ACOX1 CACNA1A CAV1 CREB3 EHHADH PEX5 PITPNA TRIP13	100 interacting genes: AARS2 ACTB ACTG1 ADARB1 ANKRD36B ARMC12 ARMCX3 BHLHE40 BOLL CAT CBS CCDC102B CCDC13 CDR2L CEP83 CISD2 CLDN18 CLDN5 CLK2 CMTM6 COQ9 CYB561 CYB561A3 DAAM2 DERL3 DES EMP1 ERGIC1 FGF14 FUNDC1 GAS8 GMCL1 GRIPAP1 HID1 HIP1 HSD17B11 HTATIP2 JAGN1 KCTD6 KCTD9 KRTAP10-7 KRTAP4-11 LCN2 LEPROTL1 LYPD5 LZTFL1 LZTS2 MAB21L3 MID1 MTUS2 NACC1 NECAB2 OPRM1 ORMDL1 PAQR8 PICK1 PNMA1 PNMA5 PPP1R12C PRKRA PSTPIP1 PTGES REL RNF4 RPRM RUSF1 SCARA5 SCP2 SDR16C5 SGCB SLC14A2 SLC39A2 SMIM5 SMN1 SMN2 SSNA1 SSX2IP SYNGR3 TMEM121 TMEM17 TMEM31 TMEM35A TNIP1 TPP2 TRAF1 TRIM21 TRIM23 TRIM27 TRIM41 TRIM5 TRIM54 TRIM55 TRIM63 VAC14 ZBTB10 ZBTB26 ZBTB8A ZBTB9 ZCCHC17 ZRANB1
Entrez ID		6342	1962
HPRD ID		01700	06125
Ensembl ID		ENSG00000116171	ENSG00000113790
Uniprot IDs		A0A384NY87 B2R761 E9PLD1 P22307 Q59HG9	Q08426
PDB IDs		1QND 2C0L
Enriched GO Terms of Interacting Partners?
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