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EHHADH and CAT
Data Source:
BioGRID
(proximity labelling technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology)
EHHADH
CAT
Description
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
catalase
Image
No pdb structure
GO Annotations
Cellular Component
Peroxisome
Peroxisomal Matrix
Cytosol
Extracellular Region
Cytoplasm
Mitochondrion
Mitochondrial Intermembrane Space
Lysosome
Peroxisome
Peroxisomal Membrane
Peroxisomal Matrix
Endoplasmic Reticulum
Golgi Apparatus
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Protein-containing Complex
Secretory Granule Lumen
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Ficolin-1-rich Granule Lumen
Molecular Function
3-hydroxyacyl-CoA Dehydrogenase Activity
Dodecenoyl-CoA Delta-isomerase Activity
Enoyl-CoA Hydratase Activity
Protein Binding
Long-chain-enoyl-CoA Hydratase Activity
Long-chain-3-hydroxyacyl-CoA Dehydrogenase Activity
Intramolecular Oxidoreductase Activity, Transposing C=C Bonds
Enzyme Binding
Peroxisome Targeting Sequence Binding
Aminoacylase Activity
Catalase Activity
Antioxidant Activity
Oxidoreductase Activity, Acting On Peroxide As Acceptor
Enzyme Binding
Heme Binding
Identical Protein Binding
Protein Homodimerization Activity
Metal Ion Binding
NADP Binding
Biological Process
Protein Targeting To Peroxisome
Fatty Acid Beta-oxidation
Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase
Response To Reactive Oxygen Species
Osteoblast Differentiation
Ureteric Bud Development
Response To Hypoxia
Protein Targeting To Peroxisome
Triglyceride Metabolic Process
Aging
Cholesterol Metabolic Process
Aerobic Respiration
Response To Light Intensity
UV Protection
Response To Ozone
Response To Lead Ion
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Response To Activity
Response To Inactivity
Hemoglobin Metabolic Process
Negative Regulation Of NF-kappaB Transcription Factor Activity
Response To Estradiol
Response To Insulin
Response To Vitamin A
Response To Vitamin E
Response To L-ascorbic Acid
Cellular Response To Oxidative Stress
Response To Drug
Response To Hydrogen Peroxide
Hydrogen Peroxide Catabolic Process
Negative Regulation Of Apoptotic Process
Neutrophil Degranulation
Response To Ethanol
Response To Cadmium Ion
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Cell Division
Response To Hyperoxia
Response To Fatty Acid
Cellular Response To Growth Factor Stimulus
Response To Phenylpropanoid
Cellular Oxidant Detoxification
Pathways
Beta-oxidation of very long chain fatty acids
Peroxisomal protein import
Peroxisomal protein import
Detoxification of Reactive Oxygen Species
Neutrophil degranulation
Peroxisomal protein import
Peroxisomal protein import
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs
NADH
Fomepizole
Cannabidiol
Medical Cannabis
Nabiximols
Diseases
Acatalasia, including: Acatalasemia; Takahara's disease; Hypocatalasemia
GWAS
Cognitive performance (
19734545
)
Major depressive disorder (
27519822
21042317
)
Blood protein levels (
30072576
29875488
28240269
)
Interacting Genes
100 interacting genes:
AARS2
ACTB
ACTG1
ADARB1
ANKRD36B
ARMC12
ARMCX3
BHLHE40
BOLL
CAT
CBS
CCDC102B
CCDC13
CDR2L
CEP83
CISD2
CLDN18
CLDN5
CLK2
CMTM6
COQ9
CYB561
CYB561A3
DAAM2
DERL3
DES
EMP1
ERGIC1
FGF14
FUNDC1
GAS8
GMCL1
GRIPAP1
HID1
HIP1
HSD17B11
HTATIP2
JAGN1
KCTD6
KCTD9
KRTAP10-7
KRTAP4-11
LCN2
LEPROTL1
LYPD5
LZTFL1
LZTS2
MAB21L3
MID1
MTUS2
NACC1
NECAB2
OPRM1
ORMDL1
PAQR8
PICK1
PNMA1
PNMA5
PPP1R12C
PRKRA
PSTPIP1
PTGES
REL
RNF4
RPRM
RUSF1
SCARA5
SCP2
SDR16C5
SGCB
SLC14A2
SLC39A2
SMIM5
SMN1
SMN2
SSNA1
SSX2IP
SYNGR3
TMEM121
TMEM17
TMEM31
TMEM35A
TNIP1
TPP2
TRAF1
TRIM21
TRIM23
TRIM27
TRIM41
TRIM5
TRIM54
TRIM55
TRIM63
VAC14
ZBTB10
ZBTB26
ZBTB8A
ZBTB9
ZCCHC17
ZRANB1
8 interacting genes:
ABL1
ABL2
APP
EHHADH
KEAP1
PTPN11
SUMO4
TLR10
Entrez ID
1962
847
HPRD ID
06125
00282
Ensembl ID
ENSG00000113790
ENSG00000121691
Uniprot IDs
Q08426
A0A384P5Q0
P04040
PDB IDs
1DGB
1DGF
1DGG
1DGH
1F4J
1QQW
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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