SCP2 and ACAA2

Data Source:
HPRD (in vitro)

		SCP2	ACAA2
Description		sterol carrier protein 2	acetyl-CoA acyltransferase 2
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Peroxisome Peroxisomal Matrix Cytosol Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle	Mitochondrion Mitochondrial Matrix
	Molecular Function	Fatty-acyl-CoA Binding Acetyl-CoA C-acyltransferase Activity Signaling Receptor Binding Protein Binding Cholesterol Binding Sterol Binding Propanoyl-CoA C-acyltransferase Activity Long-chain Fatty Acyl-CoA Binding Propionyl-CoA C2-trimethyltridecanoyltransferase Activity Acetyl-CoA C-myristoyltransferase Activity Oleic Acid Binding	RNA Binding Acetyl-CoA C-acetyltransferase Activity Acetyl-CoA Hydrolase Activity Acetyl-CoA C-acyltransferase Activity Protein Binding Palmitoyl-CoA Hydrolase Activity Acyl-CoA Hydrolase Activity Myristoyl-CoA Hydrolase Activity
	Biological Process	Protein Targeting To Peroxisome Fatty Acid Beta-oxidation Steroid Biosynthetic Process Bile Acid Biosynthetic Process Bile Acid Metabolic Process Phospholipid Transport Positive Regulation Of Intracellular Cholesterol Transport Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Lipid Hydroperoxide Transport	Fatty Acid Beta-oxidation Cholesterol Biosynthetic Process Cellular Response To Hypoxia Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Pathways		alpha-linolenic acid (ALA) metabolism Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins	Mitochondrial Fatty Acid Beta-Oxidation
Drugs
Diseases		Peroxisomal beta-oxidation enzyme deficiency, including: Acyl-CoA oxidase (ACOX) deficiency; D-bifunctional protein (DBP) deficiency; Perrault syndrome; Sterol carrier protein X (SCPx) deficiency; 2-Methylacyl-CoA racemase (AMCR) deficiency; Hypercholanemia Leukoencephalopathy with dystonia and motor neuropathy
GWAS			Acute anterior uveitis in ankylosing spondylitis ( 32492107) Apolipoprotein A1 levels ( 29084231) Cerebrospinal fluid immune biomarker levels ( 32066700) Cholesterol ester levels in very large HDL ( 29084231) Free cholesterol levels in medium HDL ( 29084231) HDL cholesterol ( 18193044) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heschl's gyrus morphology ( 25130324) Large HDL particle concentration ( 29084231) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Mean diameter of HDL particles ( 29084231) Medium HDL particle concentration ( 29084231) Phospholipid levels in large HDL ( 29084231) Phospholipid levels in medium HDL ( 29084231) Refractive error ( 32231278) Response to selective serotonin reuptake inhibitors in depression ( 27622933) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Total cholesterol levels in HDL ( 29084231) Total cholesterol levels in large HDL ( 29084231)
Interacting Genes		9 interacting genes: ACAA2 ACOX1 CACNA1A CAV1 CREB3 EHHADH PEX5 PITPNA TRIP13	5 interacting genes: APP HSPB2 LAMTOR5 SCP2 TERT
Entrez ID		6342	10449
HPRD ID		01700	10380
Ensembl ID		ENSG00000116171	ENSG00000167315
Uniprot IDs		A0A384NY87 B2R761 E9PLD1 P22307 Q59HG9	B3KNP8 P42765
PDB IDs		1QND 2C0L	4C2J 4C2K
Enriched GO Terms of Interacting Partners?
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