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EHHADH and TRIM21
Data Source:
BioGRID
(two hybrid)
EHHADH
TRIM21
Description
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
tripartite motif containing 21
Image
No pdb structure
GO Annotations
Cellular Component
Peroxisome
Peroxisomal Matrix
Cytosol
P-body
Nucleus
Nucleoplasm
Cytoplasm
Autophagosome
Cytosol
SCF Ubiquitin Ligase Complex
Cytoplasmic Vesicle
Ribonucleoprotein Complex
Molecular Function
3-hydroxyacyl-CoA Dehydrogenase Activity
Dodecenoyl-CoA Delta-isomerase Activity
Enoyl-CoA Hydratase Activity
Protein Binding
Long-chain-enoyl-CoA Hydratase Activity
Long-chain-3-hydroxyacyl-CoA Dehydrogenase Activity
Intramolecular Oxidoreductase Activity, Transposing C=C Bonds
Enzyme Binding
DNA Binding
Transcription Coactivator Activity
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Protein Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Ubiquitin Protein Ligase Activity
Biological Process
Protein Targeting To Peroxisome
Fatty Acid Beta-oxidation
Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase
Protein Polyubiquitination
Protein Monoubiquitination
Cell Cycle
Regulation Of Gene Expression
Positive Regulation Of Autophagy
Protein Ubiquitination
Protein Destabilization
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Protein Binding
Regulation Of Type I Interferon Production
Regulation Of Protein Localization
Negative Regulation Of Viral Transcription
Response To Interferon-gamma
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Positive Regulation Of Cell Cycle
Negative Regulation Of Innate Immune Response
Positive Regulation Of Transcription, DNA-templated
Regulation Of Viral Entry Into Host Cell
Positive Regulation Of Viral Entry Into Host Cell
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Autoubiquitination
Interferon-gamma-mediated Signaling Pathway
Protein K63-linked Ubiquitination
Negative Regulation Of Protein Deubiquitination
Negative Regulation Of Viral Release From Host Cell
Pathways
Beta-oxidation of very long chain fatty acids
Peroxisomal protein import
Peroxisomal protein import
STING mediated induction of host immune responses
Regulation of innate immune responses to cytosolic DNA
Interferon gamma signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
NADH
Diseases
GWAS
Cognitive performance (
19734545
)
Major depressive disorder (
27519822
21042317
)
Lung cancer (
28604730
)
Malaria (
31844061
)
Interacting Genes
100 interacting genes:
AARS2
ACTB
ACTG1
ADARB1
ANKRD36B
ARMC12
ARMCX3
BHLHE40
BOLL
CAT
CBS
CCDC102B
CCDC13
CDR2L
CEP83
CISD2
CLDN18
CLDN5
CLK2
CMTM6
COQ9
CYB561
CYB561A3
DAAM2
DERL3
DES
EMP1
ERGIC1
FGF14
FUNDC1
GAS8
GMCL1
GRIPAP1
HID1
HIP1
HSD17B11
HTATIP2
JAGN1
KCTD6
KCTD9
KRTAP10-7
KRTAP4-11
LCN2
LEPROTL1
LYPD5
LZTFL1
LZTS2
MAB21L3
MID1
MTUS2
NACC1
NECAB2
OPRM1
ORMDL1
PAQR8
PICK1
PNMA1
PNMA5
PPP1R12C
PRKRA
PSTPIP1
PTGES
REL
RNF4
RPRM
RUSF1
SCARA5
SCP2
SDR16C5
SGCB
SLC14A2
SLC39A2
SMIM5
SMN1
SMN2
SSNA1
SSX2IP
SYNGR3
TMEM121
TMEM17
TMEM31
TMEM35A
TNIP1
TPP2
TRAF1
TRIM21
TRIM23
TRIM27
TRIM41
TRIM5
TRIM54
TRIM55
TRIM63
VAC14
ZBTB10
ZBTB26
ZBTB8A
ZBTB9
ZCCHC17
ZRANB1
71 interacting genes:
ALOX15B
APC
CALR
CASP8AP2
CBX4
CDC34
CUL1
CWC25
DAXX
DCP2
DMAP1
DZIP3
EHHADH
EXOC8
FADD
FBXW11
FHOD1
GABARAP
GABARAPL1
GABARAPL2
GMCL1
GRAP
HLA-DRB1
IGFN1
IGHG1
IGHV4-31
IKBKB
IRF5
IRF8
LNX1
MAP1LC3A
MAP1LC3B
MAP1LC3C
MNAT1
NIF3L1
PFKP
RBCK1
RNF111
RO60
SAMHD1
SETD7
SKP2
SQSTM1
TBK1
TCP11L1
TNS4
TRIM27
TRIM3
TRIM39
TRIM5
TRIM8
TXN2
UBC
UBE2C
UBE2D1
UBE2D2
UBE2E1
UBE2H
UBE2I
UBE2L3
UBE2N
UBE2V2
UBE2W
USP15
USP2
USP4
VPS9D1
XAF1
YJU2
YWHAZ
ZBTB16
Entrez ID
1962
6737
HPRD ID
06125
00170
Ensembl ID
ENSG00000113790
ENSG00000132109
Uniprot IDs
Q08426
P19474
PDB IDs
2IWG
5JPX
5OLM
6FGA
6S53
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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