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RNF4 and MYD88
Data Source:
BioGRID
(two hybrid)
RNF4
MYD88
Description
ring finger protein 4
MYD88 innate immune signal transduction adaptor
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Body
PML Body
Microtubule End
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Endosome Membrane
Postsynaptic Density
Protein-containing Complex
Molecular Function
DNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
Nuclear Receptor Coactivator Activity
Nucleosome Binding
SUMO Polymer Binding
Identical Protein Binding
Toll Binding
Death Receptor Binding
Interleukin-1 Receptor Binding
Protein Binding
Toll-like Receptor Binding
Identical Protein Binding
Protein Self-association
TIR Domain Binding
Biological Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Response To Arsenic-containing Substance
Protein Autoubiquitination
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Protein K6-linked Ubiquitination
Regulation Of Spindle Assembly
Regulation Of Kinetochore Assembly
Toll-like Receptor Signaling Pathway
Response To Molecule Of Fungal Origin
MyD88-dependent Toll-like Receptor Signaling Pathway
Phagocytosis
Apoptotic Process
Inflammatory Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
JNK Cascade
Toll Signaling Pathway
Response To Virus
Induced Systemic Resistance
Positive Regulation Of Gene Expression
Immunoglobulin Mediated Immune Response
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Type I Interferon Production
Response To Peptidoglycan
Positive Regulation Of Chemokine Production
Positive Regulation Of Interleukin-17 Production
Positive Regulation Of Interleukin-23 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Toll-like Receptor 9 Signaling Pathway
Defense Response To Bacterium
Defense Response To Protozoan
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Positive Regulation Of JNK Cascade
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Lymphocyte Proliferation
Regulation Of Inflammatory Response
Defense Response To Gram-positive Bacterium
Positive Regulation Of NF-kappaB Transcription Factor Activity
Type I Interferon Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
3'-UTR-mediated MRNA Stabilization
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Establishment Of Endothelial Intestinal Barrier
Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Regulation Of Neutrophil Migration
Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways
Processing of DNA double-strand break ends
Antigen processing: Ubiquitination & Proteasome degradation
ER-Phagosome pathway
PIP3 activates AKT signaling
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
RIP-mediated NFkB activation via ZBP1
p75NTR recruits signalling complexes
p75NTR recruits signalling complexes
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
MyD88 deficiency (TLR2/4)
MyD88 deficiency (TLR5)
IRAK4 deficiency (TLR5)
IRAK4 deficiency (TLR2/4)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-1 signaling
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome
MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS
Colorectal adenoma (advanced) (
29228715
)
Colorectal cancer (
29228715
)
Coronary artery calcified atherosclerotic plaque score in type 2 diabetes (
29221444
)
Dimensional psychopathology (Social) (
29496196
)
Tourette syndrome (
30818990
)
Gut microbiota (bacterial taxa) (
27723756
)
Mean corpuscular hemoglobin concentration (
29403010
)
Interacting Genes
133 interacting genes:
ACTB
AIM2
AKAP17A
AR
ARID3C
ATF2
ATXN1
BCL2L1
BTBD1
BTBD3
C14orf119
C18orf25
CAMK2B
CAMK2D
CCL2
CFL2
CREB1
DAXX
DDX39A
DDX39B
DES
DESI1
EHHADH
ESR1
ESRRA
FADD
FAM118A
FAM9A
FKBP6
GMCL1
GSC2
H3C14
HGS
HMGA1
HNF4A
HNRNPC
HNRNPCL1
HNRNPCL2
HNRNPH1
HNRNPK
IKBKG
IKZF1
IMPDH1
KLHL12
LCE1B
LCE1D
LCE1E
LCE1F
LCE2B
LCE2C
LCE2D
LCE3B
LCE5A
LXN
MYD88
NKX3-1
NMNAT1
NTAQ1
NVL
PAICS
PATZ1
PCBP3
PGR
PHC1
PROP1
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
RHOXF2
RUNX1T1
SCML2
SEPTIN3
SKIL
SNAPC5
SOX5
SP1
SRPK2
SSNA1
STX1A
STX2
STX4
SUMO1
SUMO2
TBP
TCF20
TERF2
TFG
THAP1
TRAF2
TRAF3
TRAF4
TRAF5
TRAIP
TRIM28
TRIM38
TRIM54
TRIP13
TRPS1
UBC
UBE2A
UBE2B
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2I
UBE2K
UBE2L6
UBE2N
UBE2T
UBE2W
UBQLN1
UBQLN2
UBTD2
UEVLD
VENTX
ZBTB26
ZBTB34
ZBTB6
ZC3H10
ZCCHC17
ZFP42
ZNF275
ZNF319
ZNF696
ZNF792
ZNRD2
43 interacting genes:
BTK
CD93
CISH
FADD
FLII
IKBKG
IL1R1
IL1RAP
IL1RL1
IRAK1
IRAK2
IRAK3
IRAK4
IRF4
IRF5
IRF7
MAL
MBIP
MDM2
NTAQ1
PELI2
PFKL
POLR1C
PRDX1
RAC1
RNF4
SARM1
SIAH2
SMAD3
SPOP
SPOPL
STAP2
TIRAP
TLR10
TLR2
TLR3
TLR4
TLR5
TLR7
TLR8
TXN
USP7
ZNF35
Entrez ID
6047
4615
HPRD ID
04167
03703
Ensembl ID
ENSG00000063978
ENSG00000172936
Uniprot IDs
P78317
A0A0A0MSI9
A0A3B3ITY3
A0A3F2YP85
Q99836
PDB IDs
2EA6
2XEU
4PPE
2JS7
2Z5V
3MOP
4DOM
4EO7
6I3N
Enriched GO Terms of Interacting Partners
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