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MYD88 and NTAQ1
Data Source:
BioGRID
(two hybrid)
MYD88
NTAQ1
Description
MYD88 innate immune signal transduction adaptor
N-terminal glutamine amidase 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Endosome Membrane
Postsynaptic Density
Protein-containing Complex
Nucleus
Cytosol
Molecular Function
Toll Binding
Death Receptor Binding
Interleukin-1 Receptor Binding
Protein Binding
Toll-like Receptor Binding
Identical Protein Binding
Protein Self-association
TIR Domain Binding
Protein Binding
Protein-N-terminal Asparagine Amidohydrolase Activity
Protein-N-terminal Glutamine Amidohydrolase Activity
Biological Process
Toll-like Receptor Signaling Pathway
Response To Molecule Of Fungal Origin
MyD88-dependent Toll-like Receptor Signaling Pathway
Phagocytosis
Apoptotic Process
Inflammatory Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
JNK Cascade
Toll Signaling Pathway
Response To Virus
Induced Systemic Resistance
Positive Regulation Of Gene Expression
Immunoglobulin Mediated Immune Response
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Type I Interferon Production
Response To Peptidoglycan
Positive Regulation Of Chemokine Production
Positive Regulation Of Interleukin-17 Production
Positive Regulation Of Interleukin-23 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Toll-like Receptor 9 Signaling Pathway
Defense Response To Bacterium
Defense Response To Protozoan
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Positive Regulation Of JNK Cascade
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Lymphocyte Proliferation
Regulation Of Inflammatory Response
Defense Response To Gram-positive Bacterium
Positive Regulation Of NF-kappaB Transcription Factor Activity
Type I Interferon Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
3'-UTR-mediated MRNA Stabilization
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Establishment Of Endothelial Intestinal Barrier
Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Regulation Of Neutrophil Migration
Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Cellular Protein Modification Process
Pathways
ER-Phagosome pathway
PIP3 activates AKT signaling
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
RIP-mediated NFkB activation via ZBP1
p75NTR recruits signalling complexes
p75NTR recruits signalling complexes
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
MyD88 deficiency (TLR2/4)
MyD88 deficiency (TLR5)
IRAK4 deficiency (TLR5)
IRAK4 deficiency (TLR2/4)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-1 signaling
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome
MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS
Gut microbiota (bacterial taxa) (
27723756
)
Mean corpuscular hemoglobin concentration (
29403010
)
Interacting Genes
43 interacting genes:
BTK
CD93
CISH
FADD
FLII
IKBKG
IL1R1
IL1RAP
IL1RL1
IRAK1
IRAK2
IRAK3
IRAK4
IRF4
IRF5
IRF7
MAL
MBIP
MDM2
NTAQ1
PELI2
PFKL
POLR1C
PRDX1
RAC1
RNF4
SARM1
SIAH2
SMAD3
SPOP
SPOPL
STAP2
TIRAP
TLR10
TLR2
TLR3
TLR4
TLR5
TLR7
TLR8
TXN
USP7
ZNF35
380 interacting genes:
AARD
ACD
ACOT13
ACTB
ACTG1
ACTN2
ACY1
ADAMTSL4
AGR2
AGR3
AIMP2
AKIRIN2
AMOT
AMOTL2
AMPD2
ANKRD11
ANKRD36B
AOC1
APIP
ARID4B
ARL6IP1
ASL
ATP6V1G1
BANF2
BCL2L2-PABPN1
BEND5
BIRC7
BLMH
BLOC1S6
BLZF1
BOLA2
BOLA2B
BORCS6
BPIFB3
BTBD1
BTBD2
BTBD6
C1orf50
CAMK2A
CAPN3
CARD9
CASP6
CAVIN4
CBFA2T2
CBS
CBY2
CCDC102B
CCDC115
CCDC152
CCDC184
CCDC197
CCHCR1
CCNB1IP1
CD22
CDA
CDCA8
CDK2AP1
CDKN2AIPNL
CDR2
CENPP
CEP170B
CEP55
CEP70
CEP85
CGGBP1
CHCHD3
CHMP4A
CMTM5
COG6
COIL
CRYAA
CRYAA2
CSNK2B
CT45A1
CTAG1A
CTAG1B
CTBP1
CTH
CUEDC1
CUTC
CYSRT1
DAB1
DCTPP1
DEUP1
DHPS
DNAL4
DNM2
DYNLT1
EDARADD
EGLN3
EIF2B1
EIF4G1
EMILIN3
ENOX2
EP400
EPN3
ETV6
EXOSC8
FAM136A
FAM72A
FAM72D
FKBP6
FTH1
FTL
GADD45GIP1
GAS7
GCSAML
GFAP
GMCL1
GMDS
GNG3
GNMT
GNPDA2
GOLGA2
GOLGA6L9
GPX7
GRAMD4
GSTA4
GSTO2
GTF2H2C
H2AP
HAUS8
HBQ1
HBZ
HEATR5A
HGD
HIGD1C
HMG20A
HOMER3
HOXB6
HPRT1
HSD17B14
HSF2BP
HSPE1
HUS1
IKZF3
IL16
IL31
INCA1
ISCA2
ITGB3BP
JAKMIP2
JUP
KASH5
KATNBL1
KCNH1
KCTD1
KCTD10
KCTD13
KCTD15
KCTD21
KCTD4
KCTD6
KCTD7
KCTD9
KEAP1
KIF21B
KLHL12
KLHL2
KLHL20
KRT27
KRT31
KRTAP10-5
KRTAP10-7
KRTAP19-2
KRTAP19-6
KRTAP3-1
KRTAP3-3
KRTAP4-2
KRTAP5-9
KRTAP6-1
KRTAP9-2
KRTAP9-4
KRTAP9-8
L3MBTL3
LCE1C
LCE1D
LCE1E
LCE1F
LCE2C
LCE5A
LDB2
LENG1
LGALS2
LGALS9B
LIN7B
LMNA
LMO1
LMO2
LMO3
LNX2
LONRF1
LRIF1
LRRC73
LSM12
LSM14B
LZTFL1
LZTS1
LZTS2
MAB21L3
MAD1L1
MAGEA11
MAGEA12
MAGEA2
MAGEA2B
MALSU1
MARCHF10
MATN4
MDFI
MED22
MIF
MIF4GD
MIOS
MIPOL1
MIS18A
MITD1
MOB2
MORN3
MPLKIP
MRFAP1L1
MRPL12
MTHFD2L
MTUS2
MVP
MXRA8
MYD88
N4BP3
NAB2
NADSYN1
NAGK
NCOA5
NDUFAB1
NECAB2
NME1
NPL
NR5A1
NT5C1A
NTAN1
NUDT14
NUDT16L1
NUDT21
OOEP
PAK5
PCBD1
PFDN5
PGPEP1
PIH1D2
PLA2G10
PLCD1
PLEKHB2
PLEKHJ1
PNMA1
PNMA2
PNMA5
POLR2J
POMC
PPCDC
PPM1K
PPP1R27
PRKAR1B
PRMT1
PRMT5
PRPS2
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PRR23B
PRTFDC1
PSMB5
PSME3
PTS
PYCR3
PYGM
RAB42
RABAC1
RASAL3
RBBP8
RBM20
RBM45
RBM48
RBPMS
RD3
REEP6
RHOQ
RILPL1
RNF138
RNF4
ROPN1
RPIA
RUSC1
S100A11
SAP18
SARS2
SAT1
SCARA5
SELENOV
SEPTIN14
SEPTIN3
SFN
SH3GLB2
SIAH1
SIKE1
SIVA1
SLAIN1
SLC15A2
SLPI
SMAP1
SMN1
SNAP29
SNRPD3
SPANXB1
SPATA32
SPDYE4
SPINDOC
SPRYD7
SSNA1
SSX2IP
STH
STMN2
STN1
STX11
SYCE1L
SYNGAP1
TAX1BP1
TBX15
TCL1A
TCP10L
TEKT1
TEPSIN
THAP1
THAP6
THAP7
THG1L
TICAM2
TIFA
TLE5
TMEM239
TNFAIP1
TNIP3
TNR
TOLLIP
TRAF1
TRAF3
TRAF5
TRIM23
TRIM27
TRIM32
TRIM5
TRIM54
TRIM69
TRIM73
TRIM9
TRIP13
TSC22D1
TSN
TSNAX
UBR1
UBR2
UFC1
UNKL
VAC14
VCP
VDR
VPS37C
VXN
XIAP
ZBED1
ZBTB8A
ZBTB8B
ZC2HC1C
ZCCHC17
ZNF165
ZNF341
ZNF436
ZNF511
ZNF618
ZSCAN16
ZSCAN32
Entrez ID
4615
55093
HPRD ID
03703
07653
Ensembl ID
ENSG00000172936
ENSG00000156795
Uniprot IDs
A0A0A0MSI9
A0A3B3ITY3
A0A3F2YP85
Q99836
A0A3B3ITD7
A0A3B3ITI2
E5RHC2
Q96HA8
PDB IDs
2JS7
2Z5V
3MOP
4DOM
4EO7
6I3N
3C9Q
4W79
6KGJ
Enriched GO Terms of Interacting Partners
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