Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
MYD88 and SARM1
Data Source:
BioGRID
(protein complementation assay)
MYD88
SARM1
Description
MYD88 innate immune signal transduction adaptor
sterile alpha and TIR motif containing 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Endosome Membrane
Postsynaptic Density
Protein-containing Complex
Cytoplasm
Mitochondrion
Cytosol
Microtubule
Axon
Dendrite
Extrinsic Component Of Mitochondrial Outer Membrane
Synapse
Molecular Function
Toll Binding
Death Receptor Binding
Interleukin-1 Receptor Binding
Protein Binding
Toll-like Receptor Binding
Identical Protein Binding
Protein Self-association
TIR Domain Binding
NAD+ Nucleosidase Activity
Protein Binding
Signaling Adaptor Activity
NAD(P)+ Nucleosidase Activity
NAD+ Nucleotidase, Cyclic ADP-ribose Generating
Biological Process
Toll-like Receptor Signaling Pathway
Response To Molecule Of Fungal Origin
MyD88-dependent Toll-like Receptor Signaling Pathway
Phagocytosis
Apoptotic Process
Inflammatory Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
JNK Cascade
Toll Signaling Pathway
Response To Virus
Induced Systemic Resistance
Positive Regulation Of Gene Expression
Immunoglobulin Mediated Immune Response
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Type I Interferon Production
Response To Peptidoglycan
Positive Regulation Of Chemokine Production
Positive Regulation Of Interleukin-17 Production
Positive Regulation Of Interleukin-23 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Toll-like Receptor 9 Signaling Pathway
Defense Response To Bacterium
Defense Response To Protozoan
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Positive Regulation Of JNK Cascade
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Lymphocyte Proliferation
Regulation Of Inflammatory Response
Defense Response To Gram-positive Bacterium
Positive Regulation Of NF-kappaB Transcription Factor Activity
Type I Interferon Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
3'-UTR-mediated MRNA Stabilization
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Establishment Of Endothelial Intestinal Barrier
Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Regulation Of Neutrophil Migration
Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Signal Transduction
Nervous System Development
Response To Glucose
NAD Catabolic Process
Cell Differentiation
Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway
Regulation Of Apoptotic Process
Innate Immune Response
Response To Axon Injury
Regulation Of Dendrite Morphogenesis
Regulation Of Neuron Death
Positive Regulation Of Neuron Death
Pathways
ER-Phagosome pathway
PIP3 activates AKT signaling
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
RIP-mediated NFkB activation via ZBP1
p75NTR recruits signalling complexes
p75NTR recruits signalling complexes
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
MyD88 deficiency (TLR2/4)
MyD88 deficiency (TLR5)
IRAK4 deficiency (TLR5)
IRAK4 deficiency (TLR2/4)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-1 signaling
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome
MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS
Gut microbiota (bacterial taxa) (
27723756
)
Mean corpuscular hemoglobin concentration (
29403010
)
Amyotrophic lateral sclerosis (
27455348
)
Amyotrophic lateral sclerosis (sporadic) (
28931804
)
Blood protein levels (
29875488
28240269
)
Osteoprotegerin levels (
25080503
)
Interacting Genes
43 interacting genes:
BTK
CD93
CISH
FADD
FLII
IKBKG
IL1R1
IL1RAP
IL1RL1
IRAK1
IRAK2
IRAK3
IRAK4
IRF4
IRF5
IRF7
MAL
MBIP
MDM2
NTAQ1
PELI2
PFKL
POLR1C
PRDX1
RAC1
RNF4
SARM1
SIAH2
SMAD3
SPOP
SPOPL
STAP2
TIRAP
TLR10
TLR2
TLR3
TLR4
TLR5
TLR7
TLR8
TXN
USP7
ZNF35
6 interacting genes:
CCDC47
IRAK2
MYD88
NLRX1
STT3A
TICAM2
Entrez ID
4615
23098
HPRD ID
03703
09664
Ensembl ID
ENSG00000172936
ENSG00000004139
Uniprot IDs
A0A0A0MSI9
A0A3B3ITY3
A0A3F2YP85
Q99836
Q05B42
Q0D2N8
Q6SZW1
PDB IDs
2JS7
2Z5V
3MOP
4DOM
4EO7
6I3N
6O0Q
6O0R
6O0S
6O0T
6O0U
6O0V
6O1B
6QWV
6WPK
7CM5
7CM6
7CM7
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?