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RNF4 and TERF2
Data Source:
BioGRID
(affinity chromatography technology, pull down)
RNF4
TERF2
Description
ring finger protein 4
telomeric repeat binding factor 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Body
PML Body
Microtubule End
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Nuclear Body
Mre11 Complex
Shelterin Complex
Axon Cytoplasm
Molecular Function
DNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
Nuclear Receptor Coactivator Activity
Nucleosome Binding
SUMO Polymer Binding
Identical Protein Binding
Double-stranded Telomeric DNA Binding
Telomerase Activity
Protein Binding
Protein C-terminus Binding
Enzyme Binding
Telomeric DNA Binding
Protein Homodimerization Activity
Protein-containing Complex Binding
G-rich Strand Telomeric DNA Binding
Biological Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Response To Arsenic-containing Substance
Protein Autoubiquitination
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Protein K6-linked Ubiquitination
Regulation Of Spindle Assembly
Regulation Of Kinetochore Assembly
Telomere Maintenance
In Utero Embryonic Development
RNA-dependent DNA Biosynthetic Process
Cell Cycle
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Telomere Capping
Telomeric Loop Formation
Protection From Non-homologous End Joining At Telomere
Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance Via Recombination
Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Positive Regulation Of Nitric-oxide Synthase Activity
Telomeric D-loop Disassembly
Protein Localization To Chromosome, Telomeric Region
Cellular Senescence
Anterograde Axonal Transport Of Messenger Ribonucleoprotein Complex
Negative Regulation Of Beta-galactosidase Activity
Negative Regulation Of Telomere Single Strand Break Repair
Negative Regulation Of Telomere Capping
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Negative Regulation Of T-circle Formation
Negative Regulation Of Exonuclease Activity
Negative Regulation Of Telomeric D-loop Disassembly
Negative Regulation Of Cellular Senescence
Pathways
Processing of DNA double-strand break ends
Antigen processing: Ubiquitination & Proteasome degradation
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS
Colorectal adenoma (advanced) (
29228715
)
Colorectal cancer (
29228715
)
Coronary artery calcified atherosclerotic plaque score in type 2 diabetes (
29221444
)
Dimensional psychopathology (Social) (
29496196
)
Tourette syndrome (
30818990
)
Body mass index (
26426971
)
Brain morphology (MOSTest) (
32665545
)
Leukocyte telomere length (
32109421
)
Logical memory (delayed recall) in normal cognition (
29274321
)
Pulse pressure (
30578418
)
Interacting Genes
133 interacting genes:
ACTB
AIM2
AKAP17A
AR
ARID3C
ATF2
ATXN1
BCL2L1
BTBD1
BTBD3
C14orf119
C18orf25
CAMK2B
CAMK2D
CCL2
CFL2
CREB1
DAXX
DDX39A
DDX39B
DES
DESI1
EHHADH
ESR1
ESRRA
FADD
FAM118A
FAM9A
FKBP6
GMCL1
GSC2
H3C14
HGS
HMGA1
HNF4A
HNRNPC
HNRNPCL1
HNRNPCL2
HNRNPH1
HNRNPK
IKBKG
IKZF1
IMPDH1
KLHL12
LCE1B
LCE1D
LCE1E
LCE1F
LCE2B
LCE2C
LCE2D
LCE3B
LCE5A
LXN
MYD88
NKX3-1
NMNAT1
NTAQ1
NVL
PAICS
PATZ1
PCBP3
PGR
PHC1
PROP1
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
RHOXF2
RUNX1T1
SCML2
SEPTIN3
SKIL
SNAPC5
SOX5
SP1
SRPK2
SSNA1
STX1A
STX2
STX4
SUMO1
SUMO2
TBP
TCF20
TERF2
TFG
THAP1
TRAF2
TRAF3
TRAF4
TRAF5
TRAIP
TRIM28
TRIM38
TRIM54
TRIP13
TRPS1
UBC
UBE2A
UBE2B
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2I
UBE2K
UBE2L6
UBE2N
UBE2T
UBE2W
UBQLN1
UBQLN2
UBTD2
UEVLD
VENTX
ZBTB26
ZBTB34
ZBTB6
ZC3H10
ZCCHC17
ZFP42
ZNF275
ZNF319
ZNF696
ZNF792
ZNRD2
58 interacting genes:
AFAP1L2
ANXA5
APEX1
ASS1
ATM
BANP
BARD1
BLM
CCDC137
CTBP1
DDX21
DDX24
EP300
GNMT
H2AX
HDGFL2
HEXIM1
HEXIM2
HMGB1
HMGN1
HMGN2
HMGN3
HMGN4
LANCL2
LYAR
MAGOHB
NAIF1
NASP
NCL
NUMA1
NUMB
NXNL1
OCM2
ORC3
ORC6
PIAS1
PIK3R3
PPM1G
PRMT1
PTMA
RNF113A
RNF4
RPL13
RPRD1B
SET
SIAH1
SP100
SRSF6
TALDO1
TERF2IP
TINF2
TMSB10
TOR1AIP1
UBE2I
WDR4
WRN
XRCC6
ZC3H18
Entrez ID
6047
7014
HPRD ID
04167
03610
Ensembl ID
ENSG00000063978
ENSG00000132604
Uniprot IDs
P78317
Q15554
PDB IDs
2EA6
2XEU
4PPE
1H6P
1VF9
1VFC
1W0U
1XG1
3BU8
3BUA
3K6G
3SJM
4M7C
4RQI
5WQD
5XYF
6J67
7C5D
Enriched GO Terms of Interacting Partners
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