MYD88 and MBIP

Data Source:
BioGRID (two hybrid)

		MYD88	MBIP
Description		MYD88 innate immune signal transduction adaptor	MAP3K12 binding inhibitory protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Endosome Membrane Postsynaptic Density Protein-containing Complex	Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Nucleolus Cytosol
	Molecular Function	Toll Binding Death Receptor Binding Interleukin-1 Receptor Binding Protein Binding Toll-like Receptor Binding Identical Protein Binding Protein Self-association TIR Domain Binding	Protein Kinase Inhibitor Activity Protein Binding Identical Protein Binding
	Biological Process	Toll-like Receptor Signaling Pathway Response To Molecule Of Fungal Origin MyD88-dependent Toll-like Receptor Signaling Pathway Phagocytosis Apoptotic Process Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway JNK Cascade Toll Signaling Pathway Response To Virus Induced Systemic Resistance Positive Regulation Of Gene Expression Immunoglobulin Mediated Immune Response Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Peptidoglycan Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 9 Signaling Pathway Defense Response To Bacterium Defense Response To Protozoan Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of JNK Cascade Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Type I Interferon Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 3'-UTR-mediated MRNA Stabilization Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Establishment Of Endothelial Intestinal Barrier Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Neutrophil Migration Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Osmosensory Signaling MAPK Cascade Histone H3 Acetylation
Pathways		ER-Phagosome pathway PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane RIP-mediated NFkB activation via ZBP1 p75NTR recruits signalling complexes p75NTR recruits signalling complexes DEx/H-box helicases activate type I IFN and inflammatory cytokines production MyD88 deficiency (TLR2/4) MyD88 deficiency (TLR5) IRAK4 deficiency (TLR5) IRAK4 deficiency (TLR2/4) PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane	HATs acetylate histones
Drugs
Diseases
GWAS		Gut microbiota (bacterial taxa) ( 27723756) Mean corpuscular hemoglobin concentration ( 29403010)	Hypertension ( 31513605) Thyroid cancer ( 22267200) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997 25743335)
Interacting Genes		43 interacting genes: BTK CD93 CISH FADD FLII IKBKG IL1R1 IL1RAP IL1RL1 IRAK1 IRAK2 IRAK3 IRAK4 IRF4 IRF5 IRF7 MAL MBIP MDM2 NTAQ1 PELI2 PFKL POLR1C PRDX1 RAC1 RNF4 SARM1 SIAH2 SMAD3 SPOP SPOPL STAP2 TIRAP TLR10 TLR2 TLR3 TLR4 TLR5 TLR7 TLR8 TXN USP7 ZNF35	44 interacting genes: BFSP2 CALM1 CCDC85B CCNC CEP63 COPS4 DGCR6 DGCR6L DIP2A DRC7 EPB41L3 EXOC8 FXR2 ING5 KAT14 KLC3 LIMS1 LMNB1 LMO2 LMO3 MAP3K12 MAPK6 MCM7 MIS18A MOAP1 MYD88 NDEL1 NINL PIK3R3 PLEKHF2 POLR1C PPFIA1 RAP1GDS1 RAPGEF1 SMARCB1 STX11 TGIF2LY TRIM55 TRIM63 TXLNA TXLNB VPS28 VTA1 WDR5
Entrez ID		4615	51562
HPRD ID		03703	14368
Ensembl ID		ENSG00000172936	ENSG00000151332
Uniprot IDs		A0A0A0MSI9 A0A3B3ITY3 A0A3F2YP85 Q99836	B2RCV0 Q9NS73
PDB IDs		2JS7 2Z5V 3MOP 4DOM 4EO7 6I3N
Enriched GO Terms of Interacting Partners?
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