RNF4 and UBE2E2

Data Source:
BioGRID (pull down, two hybrid)

		RNF4	UBE2E2
Description		ring finger protein 4	ubiquitin conjugating enzyme E2 E2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body PML Body Microtubule End	Nucleus
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Nuclear Receptor Coactivator Activity Nucleosome Binding SUMO Polymer Binding Identical Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Arsenic-containing Substance Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Regulation Of Spindle Assembly Regulation Of Kinetochore Assembly	Protein Polyubiquitination Cellular Response To DNA Damage Stimulus Protein Phosphopantetheinylation ISG15-protein Conjugation Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Processing of DNA double-strand break ends Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Colorectal adenoma (advanced) ( 29228715) Colorectal cancer ( 29228715) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Dimensional psychopathology (Social) ( 29496196) Tourette syndrome ( 30818990)	Acne (severe) ( 24927181) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Asthma ( 32296059) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Hematocrit ( 32888494) Hemoglobin ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Metabolite levels ( 23823483) Motion sickness ( 25628336) Physiological dysregulation (Mahalanobis distance) ( 32235003) Psychosis (atypical) ( 24132900) Red blood cell count ( 32888494) RR interval (tricyclic/tetracyclic antidepressant use interaction) ( 28039329) Seasonality and depression ( 30217971) Staphylococcus aureus nasal carriage (intermittent) ( 26569114) Type 2 diabetes ( 22885922 24509480 30054458 30297969 26818947 23945395 32499647 30718926 28869590) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 27918534) Visceral adipose tissue/subcutaneous adipose tissue ratio adjusted for BMI ( 27918534) Vitiligo ( 27723757)
Interacting Genes		133 interacting genes: ACTB AIM2 AKAP17A AR ARID3C ATF2 ATXN1 BCL2L1 BTBD1 BTBD3 C14orf119 C18orf25 CAMK2B CAMK2D CCL2 CFL2 CREB1 DAXX DDX39A DDX39B DES DESI1 EHHADH ESR1 ESRRA FADD FAM118A FAM9A FKBP6 GMCL1 GSC2 H3C14 HGS HMGA1 HNF4A HNRNPC HNRNPCL1 HNRNPCL2 HNRNPH1 HNRNPK IKBKG IKZF1 IMPDH1 KLHL12 LCE1B LCE1D LCE1E LCE1F LCE2B LCE2C LCE2D LCE3B LCE5A LXN MYD88 NKX3-1 NMNAT1 NTAQ1 NVL PAICS PATZ1 PCBP3 PGR PHC1 PROP1 PRR20A PRR20B PRR20C PRR20D PRR20E RHOXF2 RUNX1T1 SCML2 SEPTIN3 SKIL SNAPC5 SOX5 SP1 SRPK2 SSNA1 STX1A STX2 STX4 SUMO1 SUMO2 TBP TCF20 TERF2 TFG THAP1 TRAF2 TRAF3 TRAF4 TRAF5 TRAIP TRIM28 TRIM38 TRIM54 TRIP13 TRPS1 UBC UBE2A UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2L6 UBE2N UBE2T UBE2W UBQLN1 UBQLN2 UBTD2 UEVLD VENTX ZBTB26 ZBTB34 ZBTB6 ZC3H10 ZCCHC17 ZFP42 ZNF275 ZNF319 ZNF696 ZNF792 ZNRD2	75 interacting genes: APP ARIH1 ARIH2 ARRDC3 ASXL2 BARD1 BRCA1 CBL CHFR CUEDC1 CUL3 CUL9 DAZAP2 DTX3 DTX3L DZIP3 FAM9B IPO11 ITCH MARCHF3 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L NFE2L2 OTUB1 PCGF2 PDLIM2 PGPEP1 PRAM1 PRKN RBX1 RC3H2 RING1 RLIM RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF125 RNF126 RNF14 RNF166 RNF185 RNF19A RNF2 RNF25 RNF31 RNF4 RNF5 RNF8 SRPK1 SRPK2 STUB1 TRIM2 TRIM23 TRIM27 TRIM28 TRIM3 TRIM31 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 UBA1 UBOX5 WWP2 XIAP ZNRF1
Entrez ID		6047	7325
HPRD ID		04167	06779
Ensembl ID		ENSG00000063978	ENSG00000182247
Uniprot IDs		P78317	Q96LR5
PDB IDs		2EA6 2XEU 4PPE	1Y6L 6W9A
Enriched GO Terms of Interacting Partners?
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