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RNF4 and CCL2
Data Source:
BioGRID
(two hybrid)
RNF4
CCL2
Description
ring finger protein 4
C-C motif chemokine ligand 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Body
PML Body
Microtubule End
Extracellular Region
Extracellular Space
Molecular Function
DNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
Nuclear Receptor Coactivator Activity
Nucleosome Binding
SUMO Polymer Binding
Identical Protein Binding
Protein Kinase Activity
Signaling Receptor Binding
Protein Binding
Chemokine Activity
CCR2 Chemokine Receptor Binding
CCR Chemokine Receptor Binding
Biological Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Response To Arsenic-containing Substance
Protein Autoubiquitination
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Protein K6-linked Ubiquitination
Regulation Of Spindle Assembly
Regulation Of Kinetochore Assembly
MAPK Cascade
Angiogenesis
Monocyte Chemotaxis
Protein Phosphorylation
Chemotaxis
Inflammatory Response
Humoral Immune Response
Cytoskeleton Organization
Cell Adhesion
Signal Transduction
Cell Surface Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Receptor Signaling Pathway Via JAK-STAT
Regulation Of Cell Shape
Response To Bacterium
Animal Organ Morphogenesis
Viral Genome Replication
Cytokine-mediated Signaling Pathway
Sensory Perception Of Pain
Cellular Homeostasis
Neutrophil Chemotaxis
Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of Glial Cell Apoptotic Process
Helper T Cell Extravasation
PERK-mediated Unfolded Protein Response
Protein Kinase B Signaling
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of GTPase Activity
Astrocyte Cell Migration
Cellular Response To Fibroblast Growth Factor Stimulus
Eosinophil Chemotaxis
Macrophage Chemotaxis
Lymphocyte Chemotaxis
Positive Regulation Of T Cell Activation
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Positive Regulation Of Synaptic Transmission, Glutamatergic
Chemokine-mediated Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Lipopolysaccharide
Cellular Response To Interferon-gamma
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Cellular Response To Organic Cyclic Compound
Positive Regulation Of Calcium Ion Import
Positive Regulation Of NMDA Glutamate Receptor Activity
Negative Regulation Of Vascular Endothelial Cell Proliferation
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Apoptotic Cell Clearance
Negative Regulation Of Natural Killer Cell Chemotaxis
Pathways
Processing of DNA double-strand break ends
Antigen processing: Ubiquitination & Proteasome degradation
Chemokine receptors bind chemokines
ATF4 activates genes in response to endoplasmic reticulum stress
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Drugs
Mimosine
Danazol
Chondroitin sulfate
Diseases
GWAS
Colorectal adenoma (advanced) (
29228715
)
Colorectal cancer (
29228715
)
Coronary artery calcified atherosclerotic plaque score in type 2 diabetes (
29221444
)
Dimensional psychopathology (Social) (
29496196
)
Tourette syndrome (
30818990
)
Crohn's disease (
28067908
22412388
21102463
)
Gut microbiota (functional units) (
27694959
)
Hypothyroidism (
22493691
)
Inflammatory bowel disease (
28067908
23128233
)
Interacting Genes
133 interacting genes:
ACTB
AIM2
AKAP17A
AR
ARID3C
ATF2
ATXN1
BCL2L1
BTBD1
BTBD3
C14orf119
C18orf25
CAMK2B
CAMK2D
CCL2
CFL2
CREB1
DAXX
DDX39A
DDX39B
DES
DESI1
EHHADH
ESR1
ESRRA
FADD
FAM118A
FAM9A
FKBP6
GMCL1
GSC2
H3C14
HGS
HMGA1
HNF4A
HNRNPC
HNRNPCL1
HNRNPCL2
HNRNPH1
HNRNPK
IKBKG
IKZF1
IMPDH1
KLHL12
LCE1B
LCE1D
LCE1E
LCE1F
LCE2B
LCE2C
LCE2D
LCE3B
LCE5A
LXN
MYD88
NKX3-1
NMNAT1
NTAQ1
NVL
PAICS
PATZ1
PCBP3
PGR
PHC1
PROP1
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
RHOXF2
RUNX1T1
SCML2
SEPTIN3
SKIL
SNAPC5
SOX5
SP1
SRPK2
SSNA1
STX1A
STX2
STX4
SUMO1
SUMO2
TBP
TCF20
TERF2
TFG
THAP1
TRAF2
TRAF3
TRAF4
TRAF5
TRAIP
TRIM28
TRIM38
TRIM54
TRIP13
TRPS1
UBC
UBE2A
UBE2B
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2I
UBE2K
UBE2L6
UBE2N
UBE2T
UBE2W
UBQLN1
UBQLN2
UBTD2
UEVLD
VENTX
ZBTB26
ZBTB34
ZBTB6
ZC3H10
ZCCHC17
ZFP42
ZNF275
ZNF319
ZNF696
ZNF792
ZNRD2
28 interacting genes:
ACKR1
ACKR2
ACKR4
CCL11
CCL13
CCL15
CCL26
CCL4L1
CCL5
CCL8
CCR1
CCR10
CCR3
CCR5
CXCL17
CXCL8
CXCL9
MMP1
MMP3
MMP8
PF4
RNF4
SLC16A2
SLC22A1
SLC22A2
TMX2
VCAN
XCL2
Entrez ID
6047
6347
HPRD ID
04167
01149
Ensembl ID
ENSG00000063978
ENSG00000108691
Uniprot IDs
P78317
P13500
PDB IDs
2EA6
2XEU
4PPE
1DOK
1DOL
1DOM
1DON
1MCA
1ML0
2BDN
2NZ1
3IFD
4DN4
4R8I
4ZK9
Enriched GO Terms of Interacting Partners
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