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RAP1GDS1 and RAP1A
Data Source:
HPRD
(two hybrid)
RAP1GDS1
RAP1A
Description
Rap1 GTPase-GDP dissociation stimulator 1
RAP1A, member of RAS oncogene family
Image
GO Annotations
Cellular Component
Mitochondrion
Endoplasmic Reticulum
Cytosol
Extracellular Exosome
Cytoplasm
Early Endosome
Late Endosome
Cytosol
Plasma Membrane
Cell Junction
Guanyl-nucleotide Exchange Factor Complex
Specific Granule Membrane
Neuron Projection
Phagocytic Vesicle
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Glutamatergic Synapse
Molecular Function
GTPase Activator Activity
Protein Binding
GTPase Activity
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
GTP Binding
GDP Binding
Small GTPase Binding
Protein-containing Complex Binding
Biological Process
Vascular Associated Smooth Muscle Contraction
Myosin Filament Assembly
Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration
Positive Regulation Of GTPase Activity
Positive Regulation Of Mitochondrial Calcium Ion Concentration
Nervous System Development
Response To Carbohydrate
Positive Regulation Of Neuron Projection Development
Microvillus Assembly
Rap Protein Signal Transduction
Negative Regulation Of Collagen Biosynthetic Process
Cellular Response To Drug
Nerve Growth Factor Signaling Pathway
Neutrophil Degranulation
Positive Regulation Of GTPase Activity
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Glucose Import
Regulation Of Insulin Secretion
Establishment Of Endothelial Barrier
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To CAMP
Protein Localization To Plasma Membrane
Response To Antineoplastic Agent
Liver Regeneration
Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Regulation Of Cell Junction Assembly
Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Cellular Response To Nerve Growth Factor Stimulus
Negative Regulation Of Synaptic Vesicle Exocytosis
Positive Regulation Of Vasculogenesis
Pathways
Frs2-mediated activation
Frs2-mediated activation
ARMS-mediated activation
ARMS-mediated activation
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Rap1 signalling
MAP2K and MAPK activation
Neutrophil degranulation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
MET activates RAP1 and RAC1
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Drugs
Diseases
GWAS
Biochemical measures (
19260141
)
Response to fenofibrate (total cholesterol levels) (
27002377
)
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) (
31374203
)
Crohn's disease (
30500874
32581322
)
High altitude adaptation (
28373541
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Osteoporosis-related phenotypes (
20548944
)
Interacting Genes
23 interacting genes:
CDC42
DIRAS1
DIRAS2
DOC2A
EGFR
HRAS
KIFAP3
KRAS
MBIP
NRAS
PLEKHB1
PTPRF
PUF60
RAB6B
RAC1
RAP1A
RAP2B
RAP2C
RHOA
RNF19B
RRAS
RRAS2
ZNF451
43 interacting genes:
AFDN
APBB1IP
ARHGEF1
BIN1
BMX
BRAF
ELOA
FADD
FAF1
FAS
GABARAPL2
GANAB
HDAC1
HSPA1A
HSPA4
KRIT1
MTNR1A
NTRK1
PDE6D
PPP2R1A
PRKACA
RABAC1
RAF1
RALGDS
RAP1GAP
RAP1GDS1
RAPGEF1
RAPGEF2
RAPGEF3
RAPGEF4
RAPGEF5
RAPGEF6
RASA1
RASA3
RASGRP2
RASGRP4
RASIP1
RGL4
RGS14
RUNDC3A
SMARCA2
SMARCA4
TNFRSF10C
Entrez ID
5910
5906
HPRD ID
11763
01545
Ensembl ID
ENSG00000138698
ENSG00000116473
Uniprot IDs
B3KNU0
P52306
Q6U7G8
A8KAH9
P62834
PDB IDs
5XGC
5ZHX
1C1Y
1GUA
3KUC
4KVG
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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