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RAP1A and GABARAPL2
Data Source:
BioGRID
(enzymatic study)
RAP1A
GABARAPL2
Description
RAP1A, member of RAS oncogene family
GABA type A receptor associated protein like 2
Image
GO Annotations
Cellular Component
Cytoplasm
Early Endosome
Late Endosome
Cytosol
Plasma Membrane
Cell Junction
Guanyl-nucleotide Exchange Factor Complex
Specific Granule Membrane
Neuron Projection
Phagocytic Vesicle
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Glutamatergic Synapse
Golgi Membrane
Autophagosome Membrane
Cytoplasm
Autophagosome
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Cytoplasmic Vesicle
Molecular Function
GTPase Activity
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
GTP Binding
GDP Binding
Small GTPase Binding
Protein-containing Complex Binding
SNARE Binding
Protein Binding
Microtubule Binding
Ubiquitin Protein Ligase Binding
Beta-tubulin Binding
GABA Receptor Binding
ATPase Binding
Biological Process
Nervous System Development
Response To Carbohydrate
Positive Regulation Of Neuron Projection Development
Microvillus Assembly
Rap Protein Signal Transduction
Negative Regulation Of Collagen Biosynthetic Process
Cellular Response To Drug
Nerve Growth Factor Signaling Pathway
Neutrophil Degranulation
Positive Regulation Of GTPase Activity
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Glucose Import
Regulation Of Insulin Secretion
Establishment Of Endothelial Barrier
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To CAMP
Protein Localization To Plasma Membrane
Response To Antineoplastic Agent
Liver Regeneration
Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Regulation Of Cell Junction Assembly
Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Cellular Response To Nerve Growth Factor Stimulus
Negative Regulation Of Synaptic Vesicle Exocytosis
Positive Regulation Of Vasculogenesis
Autophagosome Assembly
Autophagy Of Mitochondrion
Intra-Golgi Vesicle-mediated Transport
Autophagy
Cellular Response To Nitrogen Starvation
Protein Transport
Macroautophagy
Positive Regulation Of ATPase Activity
Protein Localization To Endoplasmic Reticulum
Autophagosome Maturation
Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways
Frs2-mediated activation
Frs2-mediated activation
ARMS-mediated activation
ARMS-mediated activation
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Rap1 signalling
MAP2K and MAPK activation
Neutrophil degranulation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
MET activates RAP1 and RAC1
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Macroautophagy
TBC/RABGAPs
Drugs
Diseases
GWAS
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) (
31374203
)
Crohn's disease (
30500874
32581322
)
High altitude adaptation (
28373541
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Osteoporosis-related phenotypes (
20548944
)
Blood protein levels (
30072576
)
Pancreatic cancer (
25086665
)
Interacting Genes
43 interacting genes:
AFDN
APBB1IP
ARHGEF1
BIN1
BMX
BRAF
ELOA
FADD
FAF1
FAS
GABARAPL2
GANAB
HDAC1
HSPA1A
HSPA4
KRIT1
MTNR1A
NTRK1
PDE6D
PPP2R1A
PRKACA
RABAC1
RAF1
RALGDS
RAP1GAP
RAP1GDS1
RAPGEF1
RAPGEF2
RAPGEF3
RAPGEF4
RAPGEF5
RAPGEF6
RASA1
RASA3
RASGRP2
RASGRP4
RASIP1
RGL4
RGS14
RUNDC3A
SMARCA2
SMARCA4
TNFRSF10C
89 interacting genes:
AAMP
AGTRAP
AHNAK2
AMBRA1
ANK2
APP
ARFGAP1
ATG13
ATG3
ATG4A
ATG4B
ATG4D
ATG7
BCL2L13
BNIP3L
BSDC1
CALCOCO1
CALCOCO2
CLN8
CUL3
DYNLL1
DYNLL2
EGFR
ERBB2
ERBB3
ERBB4
FUNDC1
GIMAP6
GOSR1
GPR37
HAP1
HSP90AB1
INSYN1
KASH5
KBTBD6
KBTBD7
KIAA1958
KIF16B
KLHL5
KRTAP10-7
KRTAP10-9
LRSAM1
LZTR1
MAP1LC3B
MCPH1
MEFV
MLX
NBR1
NEDD4
NPSR1
NSF
NUDT15
OPTN
OSBPL3
OSBPL7
PTPRA
RAP1A
RAP2A
RB1CC1
RCN2
RETREG1
RETREG3
RPS2
SCYL3
SGTA
SIK2
SMO
SQSTM1
TAX1BP1
TBC1D25
TBC1D5
TBC1D9
TBC1D9B
TEX264
TNIP1
TP53INP1
TP53INP2
TRIM21
TRIM32
TRIM45
TSR2
UBA5
ULK1
ULK2
VDR
WDFY3
YWHAZ
ZBTB2
ZNF774
Entrez ID
5906
11345
HPRD ID
01545
16246
Ensembl ID
ENSG00000116473
ENSG00000034713
Uniprot IDs
A8KAH9
P62834
P60520
PDB IDs
1C1Y
1GUA
3KUC
4KVG
4CO7
6H8C
Enriched GO Terms of Interacting Partners
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