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RAP1A and ARHGEF1
Data Source:
BioGRID
(enzymatic study)
RAP1A
ARHGEF1
Description
RAP1A, member of RAS oncogene family
Rho guanine nucleotide exchange factor 1
Image
GO Annotations
Cellular Component
Cytoplasm
Early Endosome
Late Endosome
Cytosol
Plasma Membrane
Cell Junction
Guanyl-nucleotide Exchange Factor Complex
Specific Granule Membrane
Neuron Projection
Phagocytic Vesicle
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Glutamatergic Synapse
Cytoplasm
Cytosol
Plasma Membrane
Molecular Function
GTPase Activity
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
GTP Binding
GDP Binding
Small GTPase Binding
Protein-containing Complex Binding
G Protein-coupled Receptor Binding
RNA Binding
Guanyl-nucleotide Exchange Factor Activity
GTPase Activator Activity
Protein Binding
Biological Process
Nervous System Development
Response To Carbohydrate
Positive Regulation Of Neuron Projection Development
Microvillus Assembly
Rap Protein Signal Transduction
Negative Regulation Of Collagen Biosynthetic Process
Cellular Response To Drug
Nerve Growth Factor Signaling Pathway
Neutrophil Degranulation
Positive Regulation Of GTPase Activity
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Glucose Import
Regulation Of Insulin Secretion
Establishment Of Endothelial Barrier
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To CAMP
Protein Localization To Plasma Membrane
Response To Antineoplastic Agent
Liver Regeneration
Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Regulation Of Cell Junction Assembly
Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Cellular Response To Nerve Growth Factor Stimulus
Negative Regulation Of Synaptic Vesicle Exocytosis
Positive Regulation Of Vasculogenesis
G Protein-coupled Receptor Signaling Pathway
Rho Protein Signal Transduction
Positive Regulation Of Apoptotic Process
Positive Regulation Of GTPase Activity
Regulation Of Small GTPase Mediated Signal Transduction
Pathways
Frs2-mediated activation
Frs2-mediated activation
ARMS-mediated activation
ARMS-mediated activation
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Rap1 signalling
MAP2K and MAPK activation
Neutrophil degranulation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
MET activates RAP1 and RAC1
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Drugs
Diseases
GWAS
Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) (
31374203
)
Crohn's disease (
30500874
32581322
)
High altitude adaptation (
28373541
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Osteoporosis-related phenotypes (
20548944
)
Brain morphology (MOSTest) (
32665545
)
Hallux valgus (
32131869
)
Interacting Genes
43 interacting genes:
AFDN
APBB1IP
ARHGEF1
BIN1
BMX
BRAF
ELOA
FADD
FAF1
FAS
GABARAPL2
GANAB
HDAC1
HSPA1A
HSPA4
KRIT1
MTNR1A
NTRK1
PDE6D
PPP2R1A
PRKACA
RABAC1
RAF1
RALGDS
RAP1GAP
RAP1GDS1
RAPGEF1
RAPGEF2
RAPGEF3
RAPGEF4
RAPGEF5
RAPGEF6
RASA1
RASA3
RASGRP2
RASGRP4
RASIP1
RGL4
RGS14
RUNDC3A
SMARCA2
SMARCA4
TNFRSF10C
11 interacting genes:
ATR
CD44
CNKSR1
CSNK1E
GNA13
HRAS
PRKCA
RAP1A
RHOA
SREBF2
TCF4
Entrez ID
5906
9138
HPRD ID
01545
03511
Ensembl ID
ENSG00000116473
ENSG00000076928
Uniprot IDs
A8KAH9
P62834
A0A024R0R1
Q92888
PDB IDs
1C1Y
1GUA
3KUC
4KVG
1IAP
1SHZ
3AB3
3ODO
3ODW
3ODX
3P6A
Enriched GO Terms of Interacting Partners
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