RAP1A and RASIP1

Data Source:
HPRD (two hybrid, in vitro)

		RAP1A	RASIP1
Description		RAP1A, member of RAS oncogene family	Ras interacting protein 1
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GO Annotations	Cellular Component	Cytoplasm Early Endosome Late Endosome Cytosol Plasma Membrane Cell Junction Guanyl-nucleotide Exchange Factor Complex Specific Granule Membrane Neuron Projection Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse	Golgi Stack Cell-cell Junction Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding GDP Binding Small GTPase Binding Protein-containing Complex Binding	Protein Binding Protein Homodimerization Activity GTPase Binding
	Biological Process	Nervous System Development Response To Carbohydrate Positive Regulation Of Neuron Projection Development Microvillus Assembly Rap Protein Signal Transduction Negative Regulation Of Collagen Biosynthetic Process Cellular Response To Drug Nerve Growth Factor Signaling Pathway Neutrophil Degranulation Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Glucose Import Regulation Of Insulin Secretion Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Protein Localization To Plasma Membrane Response To Antineoplastic Agent Liver Regeneration Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Cell Junction Assembly Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Vasculogenesis	Angiogenesis Vasculogenesis Signal Transduction Negative Regulation Of Autophagy Positive Regulation Of Integrin Activation Negative Regulation Of Rho Protein Signal Transduction Regulation Of GTPase Activity Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Membrane Permeability Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity
Pathways		Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation ARMS-mediated activation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates RAP1 and RAC1 Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Crohn's disease ( 30500874 32581322) High altitude adaptation ( 28373541) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Osteoporosis-related phenotypes ( 20548944)	Alcohol consumption ( 31358974) Alcohol use disorder (total score) ( 30336701) Bipolar disorder ( 21926972) Blood protein levels in cardiovascular risk ( 28369058) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Cooked vegetable consumption ( 32066663) Crohn's disease ( 28067908 21102463) Dietary macronutrient intake ( 23372041) Estimated glomerular filtration rate ( 31015462) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Inflammatory bowel disease ( 28067908) Inflammatory skin disease ( 25574825) Mean platelet volume ( 32888494 27863252) Meat-related diet ( 32066663) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Platelet count ( 32888494) Pork consumption ( 32066663) Processed meat consumption ( 32066663) Retinal vascular caliber ( 21060863) Urinary albumin-to-creatinine ratio ( 31511532) Vitamin B levels in ischemic stroke ( 25147783) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		43 interacting genes: AFDN APBB1IP ARHGEF1 BIN1 BMX BRAF ELOA FADD FAF1 FAS GABARAPL2 GANAB HDAC1 HSPA1A HSPA4 KRIT1 MTNR1A NTRK1 PDE6D PPP2R1A PRKACA RABAC1 RAF1 RALGDS RAP1GAP RAP1GDS1 RAPGEF1 RAPGEF2 RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASA1 RASA3 RASGRP2 RASGRP4 RASIP1 RGL4 RGS14 RUNDC3A SMARCA2 SMARCA4 TNFRSF10C	8 interacting genes: ARFGAP1 HRAS LDB2 MRAS RAP1A RAP2A RRAS RRAS2
Entrez ID		5906	54922
HPRD ID		01545	15214
Ensembl ID		ENSG00000116473	ENSG00000105538
Uniprot IDs		A8KAH9 P62834	Q5U651 Q7L251 Q8IUR2
PDB IDs		1C1Y 1GUA 3KUC 4KVG	5KHO 5KHQ
Enriched GO Terms of Interacting Partners?
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