RAP1A and GANAB

Data Source:
BioGRID (two hybrid)

		RAP1A	GANAB
Description		RAP1A, member of RAS oncogene family	glucosidase II alpha subunit
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Early Endosome Late Endosome Cytosol Plasma Membrane Cell Junction Guanyl-nucleotide Exchange Factor Complex Specific Granule Membrane Neuron Projection Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse	Endoplasmic Reticulum Lumen Golgi Apparatus Membrane Glucosidase II Complex Melanosome Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	GTPase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding GDP Binding Small GTPase Binding Protein-containing Complex Binding	RNA Binding Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Protein Binding Carbohydrate Binding Glucan 1,3-alpha-glucosidase Activity Alpha-glucosidase Activity
	Biological Process	Nervous System Development Response To Carbohydrate Positive Regulation Of Neuron Projection Development Microvillus Assembly Rap Protein Signal Transduction Negative Regulation Of Collagen Biosynthetic Process Cellular Response To Drug Nerve Growth Factor Signaling Pathway Neutrophil Degranulation Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Glucose Import Regulation Of Insulin Secretion Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Protein Localization To Plasma Membrane Response To Antineoplastic Agent Liver Regeneration Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Cell Junction Assembly Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Vasculogenesis	Carbohydrate Metabolic Process Protein Folding N-glycan Processing
Pathways		Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation ARMS-mediated activation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates RAP1 and RAC1 Signaling downstream of RAS mutants Signaling by RAF1 mutants	N-glycan trimming in the ER and Calnexin/Calreticulin cycle Calnexin/calreticulin cycle Maturation of spike protein Maturation of spike protein
Drugs			Miglitol
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Crohn's disease ( 30500874 32581322) High altitude adaptation ( 28373541) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Osteoporosis-related phenotypes ( 20548944)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		43 interacting genes: AFDN APBB1IP ARHGEF1 BIN1 BMX BRAF ELOA FADD FAF1 FAS GABARAPL2 GANAB HDAC1 HSPA1A HSPA4 KRIT1 MTNR1A NTRK1 PDE6D PPP2R1A PRKACA RABAC1 RAF1 RALGDS RAP1GAP RAP1GDS1 RAPGEF1 RAPGEF2 RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASA1 RASA3 RASGRP2 RASGRP4 RASIP1 RGL4 RGS14 RUNDC3A SMARCA2 SMARCA4 TNFRSF10C	9 interacting genes: CCNH CREB3L4 CSNK2A1 LINC01554 MAPK8 PRKCSH PRRC2A PTPRC RAP1A
Entrez ID		5906	23193
HPRD ID		01545	03516
Ensembl ID		ENSG00000116473	ENSG00000089597
Uniprot IDs		A8KAH9 P62834	B4DIW2 B4DSM6 B4DZ53 E9PKU7 F5H6X6 Q14697 V9HWJ0
PDB IDs		1C1Y 1GUA 3KUC 4KVG
Enriched GO Terms of Interacting Partners?
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