RAP2A and SERPINA1

Data Source:
BioGRID (two hybrid)

		RAP2A	SERPINA1
Description		RAP2A, member of RAS oncogene family	serpin family A member 1
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Midbody Recycling Endosome Recycling Endosome Membrane	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus COPII-coated ER To Golgi Transport Vesicle Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding GDP Binding	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Identical Protein Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Microvillus Assembly Negative Regulation Of Cell Migration Actin Cytoskeleton Reorganization Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Cellular Protein Localization Cellular Response To Drug Establishment Of Protein Localization Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of JNK Cascade Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane	Platelet Degranulation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Acute-phase Response Blood Coagulation Negative Regulation Of Endopeptidase Activity Neutrophil Degranulation Post-translational Protein Modification Cellular Protein Metabolic Process COPII Vesicle Coating
Pathways			Platelet degranulation COPII-mediated vesicle transport Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Neutrophil degranulation Post-translational protein phosphorylation
Drugs		Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate	Zinc 2-[3,4-Dihydroxy-2-Hydroxymethyl-5-(2-Hydroxy-Nonyl)-Tetrahydro-Furan-2-Yloxy]-6-Hydroxymethyl-Tetra Hydro-Pyran-3,4,5-Triol Mercaptoethanol Recombinant alpha 1-antitrypsin PPL-100 Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Alpha-1-antitrypsin (A1AT) deficiency
GWAS		Gut microbiota (bacterial taxa) ( 27723756) Peripheral artery disease ( 26488411)	Alanine transaminase levels ( 28887542) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258 30679032) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757 22808956) Appendicular lean mass ( 33097823) Bitter alcoholic beverage consumption ( 31046077) Blood protein levels ( 29875488 28240269 23696881) Brain morphology (MOSTest) ( 32665545) Breast size ( 27182965) C-reactive protein levels ( 30388399) Coronary artery disease ( 29212778) Gallstone disease ( 30504769) Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273) Height ( 28552196 29782485) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Large artery stroke ( 28265093) LDL cholesterol ( 30275531) Low density lipoprotein cholesterol levels ( 32154731) Manganese levels ( 26025379) Metabolite levels ( 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Platelet count ( 27863252) Plateletcrit ( 32888494) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in smoking ( 30068317) Post bronchodilator percent predicted FEV1 in smoking ( 30068317) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum alkaline phosphatase levels ( 31666285) Serum alpha-fetoprotein levels ( 31666285) Sucrose liking ( 31005972) Total cholesterol levels ( 30275531)
Interacting Genes		32 interacting genes: ACVR1 AFDN ARHGAP29 BMPR1B EEF1A1 ENSA FKBP2 FNTB FTL GABARAPL2 GRIN1 GRIN2D MAP4K4 NEDD4 PLG RAF1 RALGDS RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASIP1 RASSF5 RGL1 RGS14 RRP9 RUNDC3A SERPINA1 SMAD1 TGFBR1 TM7SF2 TNIK	29 interacting genes: ADAMTS4 ATP5F1C CELA1 CTRB1 CTSG DERL2 DERL3 ECHS1 ELANE GLP1R GSDMB KLK1 KLK3 KLK5 LAMTOR5 LRP1 MMP11 MMP26 MMP7 PRSS1 PRSS2 PRSS3 PRTN3 RAP2A RCHY1 SDC2 SLC13A1 SMAD4 VKORC1
Entrez ID		5911	5265
HPRD ID		01547	02463
Ensembl ID		ENSG00000125249	ENSG00000197249
Uniprot IDs		P10114	E9KL23 P01009
PDB IDs		1KAO 2RAP 3RAP	1ATU 1D5S 1EZX 1HP7 1IZ2 1KCT 1OO8 1OPH 1PSI 1QLP 1QMB 2D26 2QUG 3CWL 3CWM 3DRM 3DRU 3NDD 3NDF 3NE4 3T1P 4PYW 5IO1 5NBU 5NBV 6HX4 6I4V 6I7U 6IAY 6ROD 7API 8API 9API
Enriched GO Terms of Interacting Partners?
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