MAP4K2 and PRDX4

Data Source:
BioGRID (two hybrid)

		MAP4K2	PRDX4
Description		mitogen-activated protein kinase kinase kinase kinase 2	peroxiredoxin 4
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Basolateral Plasma Membrane	Extracellular Region Nucleus Endoplasmic Reticulum Smooth Endoplasmic Reticulum Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding Thioredoxin Peroxidase Activity
	Biological Process	Activation Of MAPKKK Activity Protein Phosphorylation Vesicle Targeting Immune Response JNK Cascade Activation Of JUN Kinase Activity Intracellular Signal Transduction Innate Immune Response Positive Regulation Of JNK Cascade	Response To Oxidative Stress I-kappaB Phosphorylation Spermatogenesis Male Gonad Development Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Protein Maturation By Protein Folding Extracellular Matrix Organization Cellular Response To Stress Hydrogen Peroxide Catabolic Process Neutrophil Degranulation Cell Redox Homeostasis Reactive Oxygen Species Metabolic Process Cellular Oxidant Detoxification Negative Regulation Of Male Germ Cell Proliferation
Pathways			Neutrophil degranulation
Drugs		Fostamatinib
Diseases
GWAS		Serum uric acid levels ( 32514006) Urate levels ( 21768215)
Interacting Genes		13 interacting genes: DEFB1 HNRNPA2B1 MAP2K4 MAP3K11 MCM3AP-AS1 NACAD POT1 PRDX4 RAB8A SERPINA4 SNRNP35 TRAF2 XRCC6	25 interacting genes: A1BG ALG12 APOB CFHR1 CFHR3 CLIC1 CYP27A1 DUSP23 GLTPD2 HDAC6 LBP MAP4K2 MT-CO1 NR4A1 PLG PRDX1 PRDX2 PRDX3 RCHY1 SULT2A1 SUMO4 TBXA2R TTF2 UBC VTN
Entrez ID		5871	10549
HPRD ID		04408	05935
Ensembl ID		ENSG00000168067	ENSG00000123131
Uniprot IDs		A0A024R567 Q12851	Q13162 V9HW63
PDB IDs			2PN8 3TJB 3TJF 3TJG 3TJJ 3TJK 3TKP 3TKQ 3TKR 3TKS 4RQX 5HQP
Enriched GO Terms of Interacting Partners?
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