PRDX4 and PRDX2

Data Source:
BioGRID (two hybrid)

		PRDX4	PRDX2
Description		peroxiredoxin 4	peroxiredoxin 2
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Endoplasmic Reticulum Smooth Endoplasmic Reticulum Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Thioredoxin Peroxidase Activity	Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity
	Biological Process	Response To Oxidative Stress I-kappaB Phosphorylation Spermatogenesis Male Gonad Development Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Protein Maturation By Protein Folding Extracellular Matrix Organization Cellular Response To Stress Hydrogen Peroxide Catabolic Process Neutrophil Degranulation Cell Redox Homeostasis Reactive Oxygen Species Metabolic Process Cellular Oxidant Detoxification Negative Regulation Of Male Germ Cell Proliferation	Activation Of MAPK Activity Respiratory Burst Involved In Inflammatory Response Response To Oxidative Stress Regulation Of Hydrogen Peroxide Metabolic Process Removal Of Superoxide Radicals Positive Regulation Of Blood Coagulation Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Lipopolysaccharide Cellular Response To Stress Cellular Response To Oxidative Stress T Cell Proliferation Hydrogen Peroxide Catabolic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Leukocyte Activation Cell Redox Homeostasis Negative Regulation Of T Cell Differentiation Thymus Development Homeostasis Of Number Of Cells Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Neutrophil degranulation	Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs			3-sulfino-L-alanine N-Carbamoyl-Alanine Copper
Diseases
GWAS			Platelet distribution width ( 32888494)
Interacting Genes		25 interacting genes: A1BG ALG12 APOB CFHR1 CFHR3 CLIC1 CYP27A1 DUSP23 GLTPD2 HDAC6 LBP MAP4K2 MT-CO1 NR4A1 PLG PRDX1 PRDX2 PRDX3 RCHY1 SULT2A1 SUMO4 TBXA2R TTF2 UBC VTN	24 interacting genes: A2M APOE APP BAD CA4 CD320 CDC37 COPS5 ECSIT EXOC6 IFIT5 MAST1 NLGN3 PDGFRB PPP2R1A PPP2R1B PRDX4 PSEN1 RNF32 SAT1 SUMO4 TXNDC5 UTY YWHAZ
Entrez ID		10549	7001
HPRD ID		05935	02763
Ensembl ID		ENSG00000123131	ENSG00000167815
Uniprot IDs		Q13162 V9HW63	P32119 V9HW12
PDB IDs		2PN8 3TJB 3TJF 3TJG 3TJJ 3TJK 3TKP 3TKQ 3TKR 3TKS 4RQX 5HQP	1QMV 5B8A 5B8B 5IJT
Enriched GO Terms of Interacting Partners?
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