PRDX4 and CFHR1

Data Source:
BioGRID (two hybrid)

		PRDX4	CFHR1
Description		peroxiredoxin 4	complement factor H related 1
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GO Annotations	Cellular Component	Extracellular Region Nucleus Endoplasmic Reticulum Smooth Endoplasmic Reticulum Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Protein-containing Complex Blood Microparticle
	Molecular Function	Protein Binding Thioredoxin Peroxidase Activity	Protein Binding Identical Protein Binding
	Biological Process	Response To Oxidative Stress I-kappaB Phosphorylation Spermatogenesis Male Gonad Development Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Protein Maturation By Protein Folding Extracellular Matrix Organization Cellular Response To Stress Hydrogen Peroxide Catabolic Process Neutrophil Degranulation Cell Redox Homeostasis Reactive Oxygen Species Metabolic Process Cellular Oxidant Detoxification Negative Regulation Of Male Germ Cell Proliferation	Complement Activation Regulation Of Complement Activation Negative Regulation Of Protein Binding Cytolysis By Host Of Symbiont Cells
Pathways		Neutrophil degranulation	Regulation of Complement cascade
Drugs
Diseases
GWAS			Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration (MTAG) ( 32277175) Complement C3 and C4 levels ( 23028341) IgA nephropathy ( 25305756) Matrix metalloproteinase-8 levels ( 29212897) Nephropathy ( 21399633)
Interacting Genes		25 interacting genes: A1BG ALG12 APOB CFHR1 CFHR3 CLIC1 CYP27A1 DUSP23 GLTPD2 HDAC6 LBP MAP4K2 MT-CO1 NR4A1 PLG PRDX1 PRDX2 PRDX3 RCHY1 SULT2A1 SUMO4 TBXA2R TTF2 UBC VTN	4 interacting genes: APOA1 CFH LBP PRDX4
Entrez ID		10549	3078
HPRD ID		05935	00602
Ensembl ID		ENSG00000123131	ENSG00000244414
Uniprot IDs		Q13162 V9HW63	Q03591
PDB IDs		2PN8 3TJB 3TJF 3TJG 3TJJ 3TJK 3TKP 3TKQ 3TKR 3TKS 4RQX 5HQP	3ZD2 4MUC
Enriched GO Terms of Interacting Partners?
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