MAP4K2 and SERPINA4

Data Source:
BioGRID (two hybrid)

		MAP4K2	SERPINA4
Description		mitogen-activated protein kinase kinase kinase kinase 2	serpin family A member 4
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Basolateral Plasma Membrane	Extracellular Region Extracellular Space Platelet Dense Granule Lumen Extracellular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Activation Of MAPKKK Activity Protein Phosphorylation Vesicle Targeting Immune Response JNK Cascade Activation Of JUN Kinase Activity Intracellular Signal Transduction Innate Immune Response Positive Regulation Of JNK Cascade	Platelet Degranulation Negative Regulation Of Endopeptidase Activity
Pathways			Platelet degranulation
Drugs		Fostamatinib	Zinc Copper Zinc acetate
Diseases
GWAS		Serum uric acid levels ( 32514006) Urate levels ( 21768215)	Blood protein levels ( 30072576 29875488 28240269) Vaspin levels ( 22907691)
Interacting Genes		13 interacting genes: DEFB1 HNRNPA2B1 MAP2K4 MAP3K11 MCM3AP-AS1 NACAD POT1 PRDX4 RAB8A SERPINA4 SNRNP35 TRAF2 XRCC6	13 interacting genes: CTSD GADD45G ILK KLK1 KLK2 MAP4K2 MAPK6 NR4A1 RASA1 TAB1 TNFRSF14 TNNT1 YAE1
Entrez ID		5871	5267
HPRD ID		04408	01004
Ensembl ID		ENSG00000168067	ENSG00000100665
Uniprot IDs		A0A024R567 Q12851	A0A024R6I9 P29622
PDB IDs			6F02
Enriched GO Terms of Interacting Partners?
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