PTPN9 and CPLX4

Data Source:
BioGRID (two hybrid)

		PTPN9	CPLX4
Description		protein tyrosine phosphatase non-receptor type 9	complexin 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Neuron Projection Terminus	Plasma Membrane SNARE Complex Terminal Bouton
	Molecular Function	Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding	SNARE Binding Protein Binding Syntaxin Binding
	Biological Process	Protein Dephosphorylation Negative Regulation Of Neuron Projection Development Peptidyl-tyrosine Dephosphorylation Cellular Response To Cytokine Stimulus Positive Regulation Of Protein Localization To Plasma Membrane	Visual Perception Synaptic Vesicle Exocytosis Regulation Of Neurotransmitter Secretion Response To Stimulus
Pathways		Interleukin-37 signaling
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31015462) Height ( 25429064 31562340 20189936) Type 2 diabetes ( 30297969)	Cardiac troponin-I levels ( 31014085) Chronotype ( 27494321) Macular thickness ( 30535121) Morning vs. evening chronotype ( 27494321)
Interacting Genes		46 interacting genes: AGTRAP AQP6 ARL13B ARL6IP1 ATP5PF BSND CCR2 CDR1 CERS4 CMTM4 CMTM5 COQ3 CPLX4 CREB3 CREB3L1 DERL2 EBP FAM114A2 FKBP7 GET1 GHR GJB1 GORAB HSD17B11 HSD17B13 LIME1 LMNA MAL2 NSF PBX3 PEX12 PLIN3 REEP6 RTN3 SCAMP1 SLC16A13 SLC30A8 SLC7A1 SPAG4 STX6 SYP TMCO2 TMEM80 TMEM86B TMX2 YIF1A	92 interacting genes: ADIPOQ AGTRAP AIG1 AOC3 APOD AQP1 AQP9 ASGR1 ATP6V0C BNIP2 C14orf180 C1GALT1 C3orf52 C5 CACNG1 CCL4L2 CD81 CDIPT CDS2 CLDND2 CLEC4G CLN6 CMTM5 CNIH1 CTSA CTXN3 CYB5B CYBC1 CYP4F2 DEFB127 EMD GAD2 GIMAP1 GRM2 HACD1 HHATL HMOX1 INSIG2 LPAR3 MAL MALL MAN2B2 MGAM NINJ2 NRM ORMDL1 PGAP2 PLN PLP2 PLPP4 PNLIPRP1 PTPN9 RTP2 SEC22B SELENOK SFTPC SLC30A2 SLC30A8 SLC35A1 SLC35A4 SLC35B4 SLC38A7 SLC39A9 SMCO4 STX3 STX8 SYNJ2BP TF TMEM120B TMEM14A TMEM14B TMEM19 TMEM201 TMEM203 TMEM218 TMEM229B TMEM243 TMEM254 TMEM267 TMEM60 TMEM79 TMEM86A TMEM97 TRAF3IP3 TSPO2 UBIAD1 VAMP4 VAMP5 VKORC1 WFDC2 YIPF6 ZFPL1
Entrez ID		5780	339302
HPRD ID		02864	13091
Ensembl ID		ENSG00000169410	ENSG00000166569
Uniprot IDs		P43378 Q6IQ43	Q7Z7G2
PDB IDs		2PA5 4GE2 4GE5 4GE6 4ICZ 6KZQ 6L03
Enriched GO Terms of Interacting Partners?
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