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CPLX4 and ADIPOQ
Data Source:
BioGRID
(two hybrid)
CPLX4
ADIPOQ
Description
complexin 4
adiponectin, C1Q and collagen domain containing
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
SNARE Complex
Terminal Bouton
Extracellular Region
Collagen Trimer
Extracellular Space
Endoplasmic Reticulum
Cell Surface
Collagen-containing Extracellular Matrix
Molecular Function
SNARE Binding
Protein Binding
Syntaxin Binding
Signaling Receptor Binding
Cytokine Activity
Hormone Activity
Extracellular Matrix Structural Constituent
Protein Binding
Sialic Acid Binding
Identical Protein Binding
Protein Homodimerization Activity
Biological Process
Visual Perception
Synaptic Vesicle Exocytosis
Regulation Of Neurotransmitter Secretion
Response To Stimulus
Response To Hypoxia
Positive Regulation Of Protein Phosphorylation
Glucose Metabolic Process
Generation Of Precursor Metabolites And Energy
Fatty Acid Beta-oxidation
Signal Transduction
Response To Nutrient
Circadian Rhythm
Response To Bacterium
Response To Sucrose
Response To Glucose
Positive Regulation Of Signal Transduction
Gene Expression
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Protein Kinase A Signaling
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Cholesterol Efflux
Regulation Of Glucose Metabolic Process
Response To Activity
Fatty Acid Oxidation
Negative Regulation Of Cell Migration
Negative Regulation Of Granulocyte Differentiation
Negative Regulation Of Protein Autophosphorylation
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Interleukin-8 Production
Cellular Response To Insulin Stimulus
Positive Regulation Of Myeloid Cell Apoptotic Process
Negative Regulation Of Heterotypic Cell-cell Adhesion
Low-density Lipoprotein Particle Clearance
Response To Tumor Necrosis Factor
Cellular Response To Drug
Regulation Of Fatty Acid Biosynthetic Process
Glucose Homeostasis
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of MAP Kinase Activity
Response To Ethanol
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Macrophage Differentiation
Negative Regulation Of Gluconeogenesis
Negative Regulation Of Blood Pressure
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Fatty Acid Metabolic Process
Positive Regulation Of Glucose Import
Negative Regulation Of Hormone Secretion
Negative Regulation Of Inflammatory Response
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Negative Regulation Of Phagocytosis
Negative Regulation Of Synaptic Transmission
Brown Fat Cell Differentiation
Response To Glucocorticoid
Negative Regulation Of ERK1 And ERK2 Cascade
Response To Linoleic Acid
Detection Of Oxidative Stress
Cellular Response To CAMP
Positive Regulation Of Monocyte Chemotactic Protein-1 Production
Cellular Response To Epinephrine Stimulus
Protein Localization To Plasma Membrane
Negative Regulation Of Intracellular Protein Transport
Positive Regulation Of Lipid Transporter Activity
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Receptor Binding
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Negative Regulation Of Low-density Lipoprotein Receptor Activity
Negative Regulation Of DNA Biosynthetic Process
Positive Regulation Of Glycogen (starch) Synthase Activity
Positive Regulation Of Metanephric Glomerular Visceral Epithelial Cell Development
Positive Regulation Of CAMP-dependent Protein Kinase Activity
Positive Regulation Of Renal Albumin Absorption
Negative Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Negative Regulation Of Metanephric Mesenchymal Cell Migration
Pathways
AMPK inhibits chREBP transcriptional activation activity
AMPK inhibits chREBP transcriptional activation activity
Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
Adiponectin deficiency
GWAS
Cardiac troponin-I levels (
31014085
)
Chronotype (
27494321
)
Macular thickness (
30535121
)
Morning vs. evening chronotype (
27494321
)
Activated partial thromboplastin time (
22703881
)
Adiponectin levels (
21700879
26299439
20876611
20011104
22479202
20018283
19165155
24105470
)
Adiponectin levels (BMI-adjusted) (
26299439
)
Adiponectin levels in pregnancy (
28317342
)
Copper levels (
26025379
)
Interacting Genes
92 interacting genes:
ADIPOQ
AGTRAP
AIG1
AOC3
APOD
AQP1
AQP9
ASGR1
ATP6V0C
BNIP2
C14orf180
C1GALT1
C3orf52
C5
CACNG1
CCL4L2
CD81
CDIPT
CDS2
CLDND2
CLEC4G
CLN6
CMTM5
CNIH1
CTSA
CTXN3
CYB5B
CYBC1
CYP4F2
DEFB127
EMD
GAD2
GIMAP1
GRM2
HACD1
HHATL
HMOX1
INSIG2
LPAR3
MAL
MALL
MAN2B2
MGAM
NINJ2
NRM
ORMDL1
PGAP2
PLN
PLP2
PLPP4
PNLIPRP1
PTPN9
RTP2
SEC22B
SELENOK
SFTPC
SLC30A2
SLC30A8
SLC35A1
SLC35A4
SLC35B4
SLC38A7
SLC39A9
SMCO4
STX3
STX8
SYNJ2BP
TF
TMEM120B
TMEM14A
TMEM14B
TMEM19
TMEM201
TMEM203
TMEM218
TMEM229B
TMEM243
TMEM254
TMEM267
TMEM60
TMEM79
TMEM86A
TMEM97
TRAF3IP3
TSPO2
UBIAD1
VAMP4
VAMP5
VKORC1
WFDC2
YIPF6
ZFPL1
61 interacting genes:
ADIPOR2
AMIGO1
AQP6
ASGR2
BCL2L13
BIK
BNIP3L
BSND
BTNL9
CAMLG
CCDC107
CD200R1
CD79A
CDH13
CLDN9
CLEC10A
CLEC2D
CNR2
COQ9
CPLX4
CREB3L1
CYBC1
ERP29
FAM209A
FASN
FCGR1A
FKBP7
FNDC9
GPR152
GPR42
HSD17B11
IFNGR2
KASH5
KCNK5
KEL
MFF
MFSD14B
MFSD6
MRM1
MS4A3
MUC1
NEMP1
PEX12
PROKR2
PVR
SCN3B
SGTA
SGTB
SIGLEC12
SLC16A2
SLC22A23
SLC35C2
SLC35E3
SYAP1
SYNE4
TMEM179B
TMEM237
TMEM35A
TMPRSS2
TNFSF14
TRIM35
Entrez ID
339302
9370
HPRD ID
13091
05671
Ensembl ID
ENSG00000166569
ENSG00000181092
Uniprot IDs
Q7Z7G2
A8K660
B2R773
Q15848
PDB IDs
4DOU
6U66
6U6N
Enriched GO Terms of Interacting Partners
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