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PTPN9 and CCR2
Data Source:
BioGRID
(two hybrid)
PTPN9
CCR2
Description
protein tyrosine phosphatase non-receptor type 9
C-C motif chemokine receptor 2
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Neuron Projection Terminus
Cytoplasm
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Integral Component Of Membrane
Dendrite
Neuronal Cell Body
Perikaryon
Perinuclear Region Of Cytoplasm
Molecular Function
Protein Tyrosine Phosphatase Activity
Non-membrane Spanning Protein Tyrosine Phosphatase Activity
Protein Binding
Chemokine Receptor Activity
Protein Binding
C-C Chemokine Receptor Activity
C-C Chemokine Binding
CCR2 Chemokine Receptor Binding
Identical Protein Binding
Biological Process
Protein Dephosphorylation
Negative Regulation Of Neuron Projection Development
Peptidyl-tyrosine Dephosphorylation
Cellular Response To Cytokine Stimulus
Positive Regulation Of Protein Localization To Plasma Membrane
Blood Vessel Remodeling
Dendritic Cell Chemotaxis
Regulation Of T Cell Cytokine Production
Positive Regulation Of T-helper 1 Type Immune Response
Negative Regulation Of Type 2 Immune Response
Cellular Calcium Ion Homeostasis
Chemotaxis
Inflammatory Response
Immune Response
Cellular Defense Response
G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of Adenylate Cyclase Activity
Positive Regulation Of Cytosolic Calcium Ion Concentration
Receptor Signaling Pathway Via JAK-STAT
Response To Wounding
Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of T Cell Chemotaxis
Viral Process
Negative Regulation Of Angiogenesis
Cytokine-mediated Signaling Pathway
Sensory Perception Of Pain
Calcium-mediated Signaling
Cellular Homeostasis
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Tumor Necrosis Factor Production
Monocyte Extravasation
T-helper 17 Cell Chemotaxis
Negative Regulation Of Eosinophil Degranulation
Regulation Of T Cell Differentiation
Positive Regulation Of Alpha-beta T Cell Proliferation
Regulation Of Inflammatory Response
Positive Regulation Of Inflammatory Response
Positive Regulation Of T Cell Activation
Positive Regulation Of Synaptic Transmission, Glutamatergic
Cell Chemotaxis
Chemokine-mediated Signaling Pathway
Positive Regulation Of Monocyte Chemotaxis
Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages
Inflammatory Response To Wounding
Positive Regulation Of Cold-induced Thermogenesis
Positive Regulation Of NMDA Glutamate Receptor Activity
Macrophage Migration
Positive Regulation Of Thymocyte Migration
Positive Regulation Of Monocyte Extravasation
Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation
Positive Regulation Of Astrocyte Chemotaxis
Positive Regulation Of Hematopoietic Stem Cell Migration
Pathways
Interleukin-37 signaling
Beta defensins
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling
Drugs
INCB3284
CCX915
Plozalizumab
Diseases
GWAS
Estimated glomerular filtration rate (
31015462
)
Height (
25429064
31562340
20189936
)
Type 2 diabetes (
30297969
)
Blood protein levels (
28240269
23696881
)
Celiac disease (
22057235
20190752
25920553
24999842
)
Cerebrospinal fluid levels of Alzheimer's disease-related proteins (
25340798
)
Granulocyte percentage of myeloid white cells (
27863252
)
Inflammatory bowel disease (
26192919
)
Monocyte count (
29403010
27863252
)
Monocyte percentage of white cells (
32888494
27863252
)
Obesity-related traits (
23251661
)
Rheumatoid arthritis (
32868391
)
Ulcerative colitis (
26192919
28067908
)
Interacting Genes
46 interacting genes:
AGTRAP
AQP6
ARL13B
ARL6IP1
ATP5PF
BSND
CCR2
CDR1
CERS4
CMTM4
CMTM5
COQ3
CPLX4
CREB3
CREB3L1
DERL2
EBP
FAM114A2
FKBP7
GET1
GHR
GJB1
GORAB
HSD17B11
HSD17B13
LIME1
LMNA
MAL2
NSF
PBX3
PEX12
PLIN3
REEP6
RTN3
SCAMP1
SLC16A13
SLC30A8
SLC7A1
SPAG4
STX6
SYP
TMCO2
TMEM80
TMEM86B
TMX2
YIF1A
40 interacting genes:
APP
ARL6IP5
ATP2B1
B3GAT3
BLOC1S6
CACYBP
CD59
CD81
CDIP1
CLPTM1
DMWD
EMC10
ERGIC3
GOT1
GPR161
HERPUD1
HMOX2
JPH3
NDFIP1
NOTCH2
NTNG2
PCMT1
PLLP
PTPN9
RGR
RHOG
RTN3
S1PR5
SCG5
SLC2A1
SLC41A3
SRSF5
SUMO1
SVOP
TECPR2
TMEM161A
TMEM199
TMEM63A
TSPAN7
WLS
Entrez ID
5780
729230
HPRD ID
02864
19667
Ensembl ID
ENSG00000169410
ENSG00000121807
Uniprot IDs
P43378
Q6IQ43
A0A024R2Q0
P41597
PDB IDs
2PA5
4GE2
4GE5
4GE6
4ICZ
6KZQ
6L03
1KAD
1KP1
2MLO
2MLQ
5T1A
Enriched GO Terms of Interacting Partners
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