TWF1 and FBXO25

Data Source:
BioGRID (enzymatic study)

		TWF1	FBXO25
Description		twinfilin actin binding protein 1	F-box protein 25
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleolus Cytoplasm Cytosol Actin Filament Cell-cell Junction Focal Adhesion Actin Cytoskeleton Myofibril Filopodium Ruffle Membrane Perinuclear Region Of Cytoplasm	Ubiquitin Ligase Complex Nucleus Nucleolus SCF Ubiquitin Ligase Complex
	Molecular Function	Actin Binding Actin Monomer Binding Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Cadherin Binding Actin Filament Binding	Actin Binding Ubiquitin-protein Transferase Activity
	Biological Process	Regulation Of Lamellipodium Assembly Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Actin Filament Depolymerization Negative Regulation Of Actin Filament Polymerization Sequestering Of Actin Monomers Regulation Of Actin Phosphorylation Barbed-end Actin Filament Capping	Protein Ubiquitination
Pathways
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 27569725)	Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)
Interacting Genes		5 interacting genes: ACTC1 APP BMPR2 CSNK2B FBXO25	82 interacting genes: ANKRD13A APLF AXL BMX BRME1 C7orf50 CDK5RAP2 CDK9 CENPB CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1
Entrez ID		5756	26260
HPRD ID		10174	16439
Ensembl ID		ENSG00000151239	ENSG00000147364
Uniprot IDs		Q12792	A0A024QZ88 Q8TCJ0
PDB IDs
Enriched GO Terms of Interacting Partners?
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