SPC25 and SEC61B

Data Source:
HPRD (in vivo)

		SPC25	SEC61B
Description		SPC25 component of NDC80 kinetochore complex	SEC61 translocon subunit beta
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GO Annotations	Cellular Component	Condensed Chromosome Kinetochore Nucleus Cytosol Ndc80 Complex	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Endoplasmic Reticulum Sec Complex Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Protein Binding	RNA Binding Protein Binding Epidermal Growth Factor Binding
	Biological Process	Mitotic Spindle Organization Chromosome Segregation Cell Division	SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Posttranslational Protein Targeting To Membrane, Translocation Regulation Of Catalytic Activity
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Circulating leptin levels or HOMA-B ( 32341051) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Eosinophil counts ( 32888494) Fasting blood glucose ( 29621232) Glycemic traits (pleiotropy) ( 31021400) Granulocyte count ( 27863252) Height ( 28552196) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Metabolite levels ( 23823483) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)	Adult body size ( 32376654) Asthma ( 31959851) Callous-unemotional behaviour ( 23874384) Gestational age at birth (maternal effect) ( 28877031) HDL cholesterol levels ( 32203549) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 32203549)
Interacting Genes		4 interacting genes: HGS NDC80 SEC61B SPC24	19 interacting genes: APOB ARL6 ATP13A2 AURKA BAG6 BMPR1A BUB1 CDKN2A FBXW7 GET3 GET4 MCC MLH3 MUTYH SEC63 SERP1 SPC25 TRAM1 UBL4A
Entrez ID		57405	10952
HPRD ID		15465	06715
Ensembl ID		ENSG00000152253	ENSG00000106803
Uniprot IDs		Q9HBM1	P60468
PDB IDs		2VE7 3IZ0	6W6L
Enriched GO Terms of Interacting Partners?
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